Publications
2025
Scheufen A & Moreno-Andrés D (2025). Quantitative Live-Cell Imaging to Study Chromatin Segregation and Nuclear Reformation. Methods Mol Biol . 2025:2874:47-60. doi: 10.1007/978-1-0716-4236-8_5
2024
Jose A, Roy R, Moreno-Andrés D, Stegmaier J (2024). Automatic detection of cell-cycle stages using recurrent neural networks. PLoS One. 19(3):e0297356. doi: 0.1371/journal.pone.0297356.
Jühlen R, Grauer L, Martinelli V, Rencurel C, Fahrenkrog B. (2024). Alteration of actin cytoskeletal organisation in fetal akinesia deformation sequence. Sci Rep. 14(1):1742. doi: 10.1038/s41598-023-50615-1.
Holl K, Chatain N, Krapp S, Baumeister J, Maié T, Schmitz S, Scheufen A, Brock N, Koschmieder S, Moreno-Andrés D (2024). Calreticulin and JAK2V617F driver mutations induce distinct mitotic defects in myeloproliferative neoplasms. Sci Rep. 14(1):2810. doi: 10.1038/s41598-024-53240-8.
2023
Jühlen R, Fahrenkrog B. (2023). From the sideline: Tissue-specific nucleoporin function in health and disease, an update. FEBS Lett. doi: 10.1002/1873-3468.14761.
Moreno-Andrés D, Holl K, Antonin W (2023). The second half of mitosis and its implications in cancer biology. Seminars in Cancer Biology 88:1-17. doi: 10.1016/j.semcancer.2022.11.013.
Amm I, Weberruss M, Hellwig A, Schwarz J, Tatarek-Nossol M, Lüchtenborg C, Kallas M, Brügger B, Hurt E, Antonin W (2023). Distinct domains in Ndc1 mediate its interaction with the Nup84 complex and the nuclear membrane. Journal of Cell Biology 222(6):e202210059. doi: 10.1083/jcb.202210059
Averdunk L, Huetzen MA, Moreno-Andrés D, Kalb R, McKee S, Hsieh TC, Seibt A, Schouwink M, Lalani S, Faqeih EA, Brunet T, Boor P, Neveling K, Hoischen A, Hildebrandt B, Graf E, Lu L, Jin W, Schaper J, Omer JA, Demaret T, Fleischer N, Schindler D, Krawitz P, Mayatepek E, Wieczorek D, Wang LL, Antonin W, Jachimowicz RD, von Felbert V, Distelmaier F (2023). Biallelic variants in CRIPT cause a Rothmund-Thomson-like syndrome with increased cellular senescence. Genetics in Medicine: 100836. doi: 10.1016/j.gim.2023.100836.
Panstruga R, Antonin W, Lichius A (2023). Looking outside the box: a comparative cross-kingdom view on the cell biology of the three major lineages of eukaryotic multicellular life. Cell Mol Life Sci. 80(8):198. doi: 10.1007/s00018-023-04843-3.
2022
Antonin W, Siniossoglou S (2022). Nuclear Shape-Shifters: Lipid and Protein Dynamics at the Nuclear Envelope. Cells 11:4120. doi: 10.3390/cells11244120.
Holzer G, Antonin W (2022). Nup50 plays more than one instrument. Cell Cycle 13:1-10. doi: 10.1080/15384101.2022.2074742
Holzer G, Antonin W (2022). Nuclear Pore Complex Assembly Using Xenopus Egg Extract. Methods in Molecular Biology 2502:51-66. doi: 10.1007/978-1-0716-2337-4_3
Jühlen R, Antonin W (2022). Stretching on chromosomes sheds light on their architecture. Signal Transduct Target Ther 7(1):295. doi: 10.1038/s41392-022-01141-5
Kralt A, Wojtynek M, Fischer JS, Agote-Aran A, Mancini R, Dultz E, Noor E, Uliana F, Tatarek-Nossol M, Antonin W, Onischenko E, Medalia O, Weis K (2022). An amphipathic helix in Brl1 is required for nuclear pore complex biogenesis in S. cerevisiae. Elife 11:e78385. doi: 10.7554/eLife.78385
Moreno-Andrés D, Bhattacharyya A, Scheufen A, Stegmaier J (2022). LiveCellMiner: A new tool to analyze mitotic progression. PLoS One 7;17(7):e0270923. doi: 10.1371/journal.pone.0270923
Peters LJF, Baaten CCFMJ, Maas SL, Lu C, Nagy M, Jooss NJ, Bidzhekov K, Santovito D, Moreno-Andrés D, Jankowski J, Biessen EAL, Döring Y, Heemskerk JWM, Weber C, Kuijpers MJE, van der Vorst EPC (2022). MicroRNA-26b Attenuates Platelet Adhesion and Aggregation in Mice. Biomedicines 23;10(5):983. doi: 10.3390/biomedicines10050983
2021
Holzer G, De Magistris P, Gramminger C, Sachdev R, Magalska A, Schooley A, Scheufen A, Lennartz B, Tatarek-Nossol M, Lue H, Linder MI, Kutay U, Preisinger C, Moreno-Andrés D, Antonin W. (2021). The nucleoporin Nup50 activates the Ran guanine nucleotide exchange factor RCC1 to promote NPC assembly at the end of mitosis. EMBO Journal e108788. doi: 10.15252/embj.2021108788
Kutay U, Jühlen R, Antonin W. (2021). Mitotic disassembly and reassembly of nuclear pore complexes. Trends in Cell Biology S0962-8924(21)00139-2. doi: 10.1016/j.tcb.2021.06.011
Hamed M & Antonin W. (2021). Dunking into the Lipid Bilayer: How Direct Membrane Binding of Nucleoporins Can Contribute to Nuclear Pore Complex Structure and Assembly. Cells. 10(12):3601. doi: 10.3390/cells10123601.
2020
Holzer G, Antonin W. (2020). FXR proteins bring new perspectives to nucleoporins' homeostasis.
EMBO Journal 39(20):e106510. doi: 10.15252/embj.2020106510.
Moreno-Andrés D, Yokoyama H, Scheufen A, Holzer G, Lue H, Schellhaus AK, Weberruss M, Takagi M, Antonin W. (2020). VPS72/YL1-Mediated H2A.Z Deposition Is Required for Nuclear Reassembly after Mitosis. Cells 16;9(7):E1702. doi: 10.3390/cells9071702.
2019
Holzer G, Antonin W. (2019). Breaking the Y. PLoS Genetics 15(5):e1008109. doi: 10.1371/journal.pgen.1008109.
Zanni G, De Magistris P, Nardella M, Bellacchio E, Barresi S, Sferra A, Ciolfi A, Motta M, Lue H, Moreno-Andres D, Tartaglia M, Bertini E, Antonin W. (2019). Biallelic Variants in the Nuclear Pore Complex Protein NUP93 Are Associated with Non-progressive Congenital Ataxia. Cerebellum doi: 10.1007/s12311-019-1010-5.
Yokoyama H, Moreno-Andres D, Astrinidis SA, Hao Y, Weberruss M, Schellhaus AK, Lue H, Haramoto Y, Gruss OJ, Antonin W. (2019). Chromosome alignment maintenance requires the MAP RECQL4, mutated in the Rothmund-Thomson syndrome. Life Science Alliance 2(1). pii: e201800120. doi: 10.26508/lsa.201800120.
2018
Braun DA, Lovric S, Schapiro D, Schneider R, Marquez J, Asif M, Hussain MS, Daga A, Widmeier E, Rao J, Ashraf S, Tan W, Lusk CP, Kolb A, Jobst-Schwan T, Schmidt JM, Hoogstraten CA, Eddy K, Kitzler TM, Shril S, Moawia A, Schrage K, Khayyat AIA, Lawson JA, Gee HY, Warejko JK, Hermle T, Majmundar AJ, Hugo H, Budde B, Motameny S, Altmüller J, Noegel AA, Fathy HM, Gale DP, Waseem SS, Khan A, Kerecuk L, Hashmi S, Mohebbi N, Ettenger R, Serdaroğlu E, Alhasan KA, Hashem M, Goncalves S, Ariceta G, Ubetagoyena M, Antonin W, Baig SM, Alkuraya FS, Shen Q, Xu H, Antignac C, Lifton RP, Mane S, Nürnberg P, Khokha MK, Hildebrandt F (2018). Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome. The Journal of Clinical Investigations. pii: 98688. doi: 10.1172/JCI98688.
Holzer G and Antonin W (2018). Nuclear pore complexes: Global Conservation and Local Variation. Current Biology 28(11): R674–R677
De Magistris P and Antonin W (2018). The Dynamic Nature of the Nuclear Envelope. Current Biology 28(8): R487–R497
De Magistris P, Tatarek-Nossol M, Dewor M, Antonin W (2018). A self-inhibitory interaction within Nup155 and membrane binding are required for nuclear pore complex formation. Journal of Cell Science;131(1). pii: jcs208538. doi: 10.1242/jcs.208538
De Magistris P, Suluyayla R, and Antonin W. (2018). Wie die Zelle ihre Kernporen aufbaut. BIOspektrum 24: 20–22.
2017
Linder MI, Köhler M, Boersema P, Weberruss M, Wandke C, Marino J, Ashiono C, Picotti P, Antonin W, Kutay U (2017). Mitotic Disassembly of Nuclear Pore Complexes Involves CDK1- and PLK1-Mediated Phosphorylation of Key Interconnecting Nucleoporins. Developmental Cell 43 (2): 141–156.
Schellhaus AK, Moreno-Andrés D, Chugh M, Yokoyama H, Moschopoulou A, De S, Bono F, Hipp K, Schäffer E, Antonin W (2017). Developmentally Regulated GTP binding protein 1 (DRG1) controls microtubule dynamics. Scientific Reports. 7(1): 9996. doi: 10.1038/s41598-017-10088-5.
Silva Alves N, Astrinidis SA, Eisenhardt N, Sieverding C, Redolfi J, Lorenz M, Weberruss M, Moreno-Andrés D, Antonin W (2017). MISTIC-fusion proteins as antigens for high quality membrane protein antibodies. Scientific Reports 7:41519 | DOI: 10.1038/srep41519
2016
Braun DA, Sadowski CE, Kohl S, Lovric S, Astrinidis SA, Pabst WL, Gee HY, Ashraf S, Lawson JA, Shril S, Airik M, Tan W, Schapiro D, Rao J, Choi WI, Hermle T, Kemper MJ, Pohl M, Ozaltin F, Konrad M, Bogdanovic R, Büscher R, Helmchen U, Serdaroglu E, Lifton RP, Antonin W, Hildebrandt F (2016). Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome. Nature Genetics, 48 (4): 457-465.
Antonin W and Neumann H (2016). Chromosome condensation and decondensation during mitosis. Current Opinion in Cell Biology, 40:15-22.
Weberruss M and Antonin W (2016). Perforating the nuclear boundary - how nuclear pore complexes assemble. Journal of Cell Science 129 (24): 4439-4447
2015
Vollmer B, Lorenz M, Moreno-Andres D, Bodenhöfer M, De Magistris P, Astrinidis SA, Schooley A, Flötenmeyer M, Leptihn S, and Antonin W (2015). Nup153 recruits the Nup107-160 complex to the inner nuclear membrane for interphasic nuclear pore complex assembly. Developmental Cell, 33 (6): 717-728.
Lorenz M, Vollmer B, Unsay JD, Klupp BG, García-Sáez AJ, Mettenleiter TC, and Antonin W (2015). A Single Herpesvirus Protein can mediate Vesicle Formation in the Nuclear Envelope. Journal of Biological Chemistry, 290 (11): 6962-6974.
Schooley A, Moreno-Andrés D, De Magistris P, Vollmer B, and Antonin W (2015). The lysine demethylase LSD1 is required for nuclear envelope formation at the end of mitosis. Journal of Cell Science, 128 (18): 3466-3477.
von Appen A, Kosinski J, Sparks L, Ori A, DiGuilio AL, Vollmer B, Mackmull MT, Banterle N, Parca L, Kastritis P, Buczak K, Mosalaganti S, Hagen W, Andres-Pons A, Lemke EA, Bork P, Antonin W, Glavy JS, Bui KH, and Beck M (2015). In situ structural analysis of the human nuclear pore complex. Nature, 526 (7571): 140-143.
Schellhaus, AK, De Magistris, P, and Antonin, W (2015). Nuclear reformation at the end of mitosis. (Review) Journal of Molecular Biology, 428 (10): 1962-85
Zeev-Ben-Mordehai, T, Weberruß, M, Lorenz, M, Cheleski, J, Hellberg, T, Whittle, K, El-Omari, K, Vasishtan, D, Dent, K C, Harlos, K, Hagen, W, Klupp, BG, Antonin, W*, Mettenleiter, TC, and Grünewald, K* (2015) (* corresponding authors). Crystal structure of the herpesvirus nuclear egress complex provides insights into inner nuclear membrane remodelling. Cell Reports, 13 (12): 2645-2652.
Schellhaus, AK, Magalska, A, Schooley, A, and Antonin, W (2015). A cell free assay to study chromatin decondensation at the end of mitosis. Journal of Visual Experiments (JoVE), 106: doi: 10.3791/53407.
2014
Magalska, A, Schellhaus, AK, Moreno-Andres, D, Zanini, F, Schooley, A, Sachdev, R, Schwarz, H, Madlung, J, Gerken, J and Antonin, W (2014). RuvB-like ATPases function in chromatin decondensation at the end of mitosis. Developmental Cell, 31 (3): 305-318.
Eisenhardt, N, Redolfi, J and Antonin, W (2014). Interaction of Nup53 with NDC1 and Nup155 is required for nuclear pore complex assembly. Journal of Cell Science, 127 (4):908-921.
Vollmer, B and Antonin, W (2014). The diverse roles of the Nup93/Nic96 complex proteins - structural scaffolds of the nuclear pore complex with additional cellular functions. (Review). Biological Chemistry, 395 (5):515-528.
Eisenhardt, N, Schooley, A and Antonin, W (2014). Xenopus in vitro assays to analyze the function of transmembrane nucleoporins and targeting of inner nuclear membrane proteins. Methods in Cell Biology, 122:193-218.
2013
Antonin, W (2013). Don't get stuck in the pore. (Viewpoint). EMBO Journal, 32 (2):173-175.
2012
Sachdev, R, Sieverding, C, Flotenmeyer, M, and Antonin, W (2012). The C-terminal domain of Nup93 is essential for assembly of the structural backbone of nuclear pore complexes. Molecular Biology of the Cell, 23 (4):740-9.
Vollmer, B, Schooley, A, Sachdev, R, Eisenhardt, N, Schneider, AM, Sieverding, C, Madlung, J, Gerken, J, Macek, B, and Antonin, W (2012). Dimerization and direct membrane interaction of Nup53 contribute to nuclear pore complex assembly. EMBO Journal, 31 (20):4072-84.
Schooley, A, Vollmer, B, and Antonin, W (2012). Building a nuclear envelope at the end of mitosis: coordinating membrane reorganization, nuclear pore complex assembly, and chromatin de-condensation. (Review). Chromosoma, 121 (6):539-54.
2011
Antonin, W, Ungricht, R, and Kutay, U (2011). Traversing the NPC along the pore membrane: Targeting of membrane proteins to the INM. (Review). Nucleus, 2 (2):87-92.
Laurell, E, Beck, K, Krupina, K, Theerthagiri, G, Bodenmiller, B, Horvath, P, Aebersold, R, Antonin, W, and Kutay, U (2011). Phosphorylation of Nup98 by Multiple Kinases Is Crucial for NPC Disassembly during Mitotic Entry. Cell, 144 (4):539-50.
2010
Theerthagiri, G, Eisenhardt, N, Schwarz, H, and Antonin, W (2010). The nucleoporin Nup188 controls passage of membrane proteins across the nuclear pore complex. Journal of Cell Biology, 189 (7):1129-42.
Yavuz, S, Santarella-Mellwig, R, Koch, B, Jaedicke, A, Mattaj, IW, and Antonin, W (2010). NLS-mediated NPC functions of the nucleoporin Pom121. FEBS letters, 584 (15):3292-3298.
2009
Antonin, W (2009). Nuclear envelope: membrane bending for pore formation? (Dispatch). Current Biology, 19 (10):R410-2.
2008
Antonin, W, Ellenberg, J, and Dultz, E (2008). Nuclear pore complex assembly through the cell cycle: Regulation and membrane organization. (Review). FEBS letters, 582 (14):2004-2016.
Galy, V, Antonin, W, Jaedicke, A, Sachse, M, Santarella, R, Haselmann, U, and Mattaj, I (2008). A role for gp210 in mitotic nuclear-envelope breakdown. Journal of Cell Science, 121:317-28.
2007
Franz, C, Walczak, R, Yavuz, S, Santarella, R, Gentzel, M, Askjaer, P, Galy, V, Hetzer, M, Mattaj, IW, and Antonin, W (2007). MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly. EMBO Reports, 8 (2):165-72.
2006
Mansfeld, J, Güttinger, S, Hawryluk-Gara, LA, Pante, N, Mall, M, Galy, V, Mühlhäusser, P, Wozniak, RW, Mattaj, IW, Kutay, U, and Antonin, W (2006). The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells. Molecular Cell, 22 (1):93-103.
Ulbert, S, Antonin, W, Platani, M, and Mattaj, IW (2006). The inner nuclear membrane protein Lem2 is critical for normal nuclear envelope morphology. FEBS Letters, 580 (27):6435-41.
2005
Antonin, W, Franz, C, Haselmann, U, Antony, C, and Mattaj, IW (2005). The integral membrane nucleoporin pom121 functionally links nuclear pore complex assembly and nuclear envelope formation. Molecular Cell, 17 (1):83-92.
Antonin, W and Mattaj, IW (2005). Nuclear pore complexes: round the bend? Nature Cell Biology, 7 (1):10-2.
Franz, C, Askjaer, P, Antonin, W, Iglesias, CL, Haselmann, U, Schelder, M, Marco, Ad, Wilm, M, Antony, C, and Mattaj, IW (2005). Nup155 regulates nuclear envelope and nuclear pore complex formation in nematodes and vertebrates. EMBO Journal, 24 (20):3519-31.
