Chloé Radermacher MSc

Understanding the PDL cell / cementum interphase, their interplay under mechanical stress and periodontal remodeling to provide a basis for periodontal-cementum research

Through mastication, orthodontic tooth movement (OTM) and trauma, mechanical stimuli are generated influencing mechanosensory cells of the periodontal ligament (PDL) that is closely attached to the alveolar bone and cementum which in turn is attached to the tooth. Clinical evidence indicates that the continuous remodeling of the tooth root cementum and periodontal apparatus in response to mechanical stimulation maintains tissue strength, prevents tissue damage, and secures teeth anchorage. In this project, we aim to close the gap between the lack of knowledge how cementum and periodontal tissues are regulated in order to ensure continuous remodeling providing sufficient tooth anchorage between periodontal ligament and tooth root cementum.