European Society of Cardiology Meeting

appreciation of our contribution:

Endurance exercise and heart disease: Look for clues in the genes

.....Researchers from Birmingham, UK and colleagues in Muenster and Aachen, Germany used genetically modified mice to look at the interaction between exercise and heart disease. They knew that many patients with ARVD harbor mutations in the domain of the desmoglein 2 (DSG2) gene. They were able to genetically engineer mice lacking parts of the DSG2 gene. Those mice with two copies of the deletion (homozygous) developed profound ARVD, whereas those mice with one copy (heterozygous) did not manifest disease......