Priv.-Doz. Dr. rer. nat. Patrick Ziegler

pzieglerukaachende 
Pauwelsstraße 30, 52074 Aachen
Raum 11 (Etage 3, Aufzug D2, Gang D)
Tel.: 0241 80-35841
Fax: 0241 80-82587

Kurzbiografie

Ausbildung

2018 Habilitation Molekulare Medizin
1999-2002Dr. rer. nat. Ernst-Moritz-Arndt Universität Greifswald
1993-1998 Studium Diplom-Biologie Eberhard-Karls Universität Tübingen und Ernst-Moritz-Arndt Universität Greifswald.

 

Beruflicher Werdegang

Seit 2015Leiter der Arbeitsgruppe molekulare Arbeitsmedizin am Institut für Arbeits-, Sozial- und Umweltmedizin
2010-2015Leiter der Arbeitsgruppe mesenchymale Stammzellen und inflammatorische Hämatopoese an der Klinik für Hämatologie, Onkologie, Hämostaseologie und Stammzelltransplantation der Uniklinik RWTH Aachen
2006-2009Postdoc am Institute For Research in Biomedicine in Bellinzona, Schweiz
2003-2005Wissenschaftlicher Assistent experimentelle Hämatologie an der Klinik für Onkologie, Hämatologie, Klinische Immunologie, Rheumatologie und Pulmologie der Eberhard-Karls Universität Tübingen

 

Forschungsschwerpunkte

  • Arbeitsplatzbedingte Gefahrstoff-Exposition: in vivo-Analysen, Gesundheitsrisiken und toxikologische Auswirkungen
  • Einfluss polychlorierter Biphenyle (PCBs) auf den Medikamentenstoffwechsel im Menschen: Modulation der CYP-Enzymaktivität

Link zur Arbeitsgruppe: AG Molekulare Arbeitsmedizin

Publikationen

  • Bitar S, Baumann T, Weber C, Abusaada M, Rojas-Charry L, Ziegler P, Schettgen T, Randerath IE, Venkataramani V, Michalke B, Hanschmann EM, Arena G, Krueger R, Zhang L, Methner A. Iron-sulfur cluster loss in mitochondrial CISD1 mediates PINK1 loss-of-function phenotypes. Elife. 2024 Aug 19;13. doi: 0.7554/eLife.97027. PubMed [citation] PMID: 39159312, PMCID: PMC11383524
  • Randerath I, Schettgen T, Müller JP, Rengelshausen J, Ziegler S, Quinete N, Bertram J, Laieb S, Schaeffeler E, Kaifie A, Just KS, Voigt A, Tremmel R, Schwab M, Stingl JC, Kraus T, Ziegler P. Metabolic activation of WHO-congeners PCB28, 52, and 101 by human CYP2A6: evidence from in vitro and in vivo experiments. Arch Toxicol. 2024 Nov;98(11):3739-3753. doi: 10.1007/s00204-024-03836-w. Epub 2024 Aug 13. PubMed [citation] PMID: 39136732, PMCID: PMC11489226
  • Schettgen T, Belov V, Kraus T, Ziegler P. A novel method for the accurate quantification of two isomeric mercapturic acids of 1,3-dichlorobenzene in human urine using isotope dilution online-SPE-LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2024 Feb 15;1234:124034. doi: 10.1016/j.jchromb.2024.124034. Epub 2024 Jan 27. PubMed [citation] PMID: 38306955
  • Müller JP, Sarömba J, Ziegler P, Tremmel R, Rengelshausen J, Schaeffeler E, Just KS, Schwab M, Kraus T, Stingl JC. Nutrimetric Validation of Solanidine as Dietary-Derived CYP2D6 Activity Marker In Vivo. Clin Pharmacol Ther. 2024 Feb;115(2):309-317. doi: 10.1002/cpt.3106. Epub 2023 Dec 3. PubMed [citation] PMID: 37971251
  • Randerath I, Quinete N, Müller JP, Stingl J, Bertram J, Schettgen T, Kraus T, Ziegler P. Partial dechlorination of 2,4,4'-trichlorobiphenyl (PCB 28) mediated by recombinant human CYP1A2. Arch Toxicol. 2024 Jan;98(1):159-163. doi: 10.1007/s00204-023-03621-1. Epub 2023 Nov 2. No abstract available. PubMed [citation] PMID: 37917334, PMCID: PMC10761437
  • Rengelshausen J, Randerath I, Schettgen T, Esser A, Kaifie A, Lang J, Kraus T, Ziegler P. Ten years after: findings from the medical surveillance program on Health Effects in High-Level Exposure to PCB (HELPcB). Arch Toxicol. 2023 Oct;97(10):2609-2623. doi: 10.1007/s00204-023-03578-1. Epub 2023 Aug 18. Review. PubMed [citation] PMID: 37594590, PMCID: PMC10474999
  • Ziegler P, Quinete N, Bertram J, Randerath I, Kraus T, Schettgen T. Correspondence on "Machine Learning-Assisted Identification and Quantification of Hydroxylated Metabolites of Polychlorinated Biphenyls in Animal Samples". Environ Sci Technol. 2023 Apr 18;57(15):6248-6250. doi: 10.1021/acs.est.3c00660. Epub 2023 Apr 5. No abstract available. PubMed [citation] PMID: 37017335
  • Schettgen T, Bertram J, Krabbe J, Christoforou R, Schweiker M, Esser A, Möller M, Ziegler P, Kraus T. Excretion kinetics of 1,3-dichlorobenzene and its urinary metabolites after controlled airborne exposure in human volunteers. Arch Toxicol. 2023 Apr;97(4):1033-1045. doi: 10.1007/s00204-023-03447-x. Epub 2023 Jan 30. PubMed [citation] PMID: 36717398, PMCID: PMC10025240
  • Schreibing F, Hannani MT, Kim H, Nagai JS, Ticconi F, Fewings E, Bleckwehl T, Begemann M, Torow N, Kuppe C, Kurth I, Kranz J, Frank D, Anslinger TM, Ziegler P, Kraus T, Enczmann J, Balz V, Windhofer F, Balfanz P, Kurts C, Marx G, et al. Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling. Front Immunol. 2022 Dec 16;13:1066176. doi: 10.3389/fimmu.2022.1066176. eCollection 2022. PubMed [citation] PMID: 36591270, PMCID: PMC9800604
  • Kaifie A, Esser A, Ziegler P, Kraus T, Rauchfuss K, Schettgen T. Environmental release of non-Aroclor polychlorinated biphenyls by a silicone rubber production site did not lead to elevated plasma levels in the nearby population. Int J Hyg Environ Health. 2022 Aug;245:114028. doi: 10.1016/j.ijheh.2022.114028. Epub 2022 Aug 27. PubMed [citation] PMID: 36041276
  • Krabbe J, Kraus T, Krabbe H, Martin C, Ziegler P. Welding Fume Instillation in Isolated Perfused Mouse Lungs-Effects of Zinc- and Copper-Containing Welding Fumes. Int J Mol Sci. 2022 Aug 12;23(16). doi: 10.3390/ijms23169052. PubMed [citation] PMID: 36012318, PMCID: PMC9408907
  • Schettgen T, Esser A, Alt A, Randerath I, Kraus T, Ziegler P. Decomposition Products of the Initiator Bis(2,4-dichlorobenzoyl)peroxide in the Silicone Industry: Human Biomonitoring in Plasma and Urine of Workers. Environ Sci Technol. 2022 Jun 21;56(12):8518-8527. doi: 10.1021/acs.est.2c01530. Epub 2022 Jun 7. PubMed [citation] PMID: 35671459
  • Elsholz L, Wasser Y, Ziegler P, Habib P, Voigt A. CK1BP Reduces α-Synuclein Oligomerization and Aggregation Independent of Serine 129 Phosphorylation. Cells. 2021 Oct 21;10(11). doi: 10.3390/cells10112830. PubMed [citation] PMID: 34831053, PMCID: PMC8616157
  • Schettgen T, Esser A, Kraus T, Ziegler P. Plasma levels of unintentionally produced non-Aroclor polychlorinated biphenyl (PCB) congeners in workers from the silicone rubber industry. Chemosphere. 2022 Mar;291(Pt 1):132722. doi: 10.1016/j.chemosphere.2021.132722. Epub 2021 Oct 27. PubMed [citation] PMID: 34718009
  • Esser A, Ziegler P, Kaifie A, Kraus T, Schettgen T. Modelling past human internal exposure to lower chlorinated indicator PCBs using proxies - A calculation based on multiple longitudinal PCB analyses. Sci Total Environ. 2021 Aug 25;784:147250. doi: 10.1016/j.scitotenv.2021.147250. Epub 2021 Apr 21. PubMed [citation] PMID: 34088037
  • Beier F, Esser A, Vankann L, Abels A, Schettgen T, Kraus T, Brümmendorf TH, Ziegler P. Longitudinal changes in telomere length in PCB-exposed individuals: interaction with CMV infection. Arch Toxicol. 2021 Apr;95(4):1517-1520. doi: 10.1007/s00204-021-03019-x. Epub 2021 Mar 19. PubMed [citation] PMID: 33740104, PMCID: PMC8032634
  • Esser A, Ziegler P, Kaifie A, Kraus T, Schettgen T. Estimating plasma half-lives of dioxin like and non-dioxin like polychlorinated biphenyls after occupational exposure in the German HELPcB cohort. Int J Hyg Environ Health. 2021 Mar;232:113667. doi: 10.1016/j.ijheh.2020.113667. Epub 2020 Dec 9. PubMed [citation] PMID: 33307299
  • Idda T, Bonas C, Hoffmann J, Bertram J, Quinete N, Schettgen T, Fietkau K, Esser A, Stope MB, Leijs MM, Baron JM, Kraus T, Voigt A, Ziegler P. Metabolic activation and toxicological evaluation of polychlorinated biphenyls in Drosophila melanogaster. Sci Rep. 2020 Dec 9;10(1):21587. doi: 10.1038/s41598-020-78405-z. PubMed [citation] PMID: 33299007, PMCID: PMC7726022
  • Schröder N, Schaffrath A, Welter JA, Putzka T, Griep A, Ziegler P, Brandt E, Samer S, Heneka MT, Kaddatz H, Zhan J, Kipp E, Pufe T, Tauber SC, Kipp M, Brandenburg LO. Inhibition of formyl peptide receptors improves the outcome in a mouse model of Alzheimer disease. J Neuroinflammation. 2020 Apr 24;17(1):131. doi: 10.1186/s12974-020-01816-2. PubMed [citation] PMID: 32331524, PMCID: PMC7181500
  • Abazid A, Martin B, Choinowski A, McNeill RV, Brandenburg LO, Ziegler P, Zimmermann U, Burchardt M, Erb H, Stope MB. The androgen receptor antagonist enzalutamide induces apoptosis, dysregulates the heat shock protein system, and diminishes the androgen receptor and estrogen receptor β1 expression in prostate cancer cells. J Cell Biochem. 2019 Oct;120(10):16711-16722. doi: 10.1002/jcb.28929. Epub 2019 Jul 11. PubMed [citation] PMID: 31297844
  • Daragan G, Hoffmann J, Vasko T, Mustea A, Burchardt M, Kraus T, Stope MB, Ziegler P. Dirty deeds done dirt cheap: sensitization of prostate cancer cells to abiraterone treatment using hydroxylated polychlorinated biphenyls. Invest New Drugs. 2020 Apr;38(2):541-545. doi: 10.1007/s10637-019-00833-0. Epub 2019 Jul 11. PubMed [citation] PMID: 31292837
  • Leijs MM, Gan L, De Boever P, Esser A, Amann PM, Ziegler P, Fietkau K, Schettgen  T, Kraus T, Merk HF, Baron JM. Altered Gene Expression in Dioxin-Like and Non-Dioxin-Like PCB Exposed Peripheral Blood Mononuclear Cells. Int J Environ Res Public Health. 2019 Jun 13;16(12). doi: 10.3390/ijerph16122090. PubMed [citation] PMID: 31200452, PMCID: PMC6617415
  • Kaifie A, Schettgen T, Gube M, Ziegler P, Kraus T, Esser A. Functional and structural liver abnormalities in former PCB exposed workers - analyses from the HELPcB cohort. J Toxicol Environ Health A. 2019;82(1):52-61. doi: 10.1080/15287394.2018.1555728. Epub 2018 Dec 10. PubMed [citation] PMID: 30526399
  • Vasko T, Hoffmann J, Gostek S, Schettgen T, Quinete N, Preisinger C, Kraus T, Ziegler P. Telomerase gene expression bioassays indicate metabolic activation of genotoxic lower chlorinated polychlorinated biphenyls. Sci Rep. 2018 Nov 15;8(1):16903. doi: 10.1038/s41598-018-35043-w. PubMed [citation] PMID: 30443001, PMCID: PMC6237825
  • Kaifie A, Schikowsky C, Vasko T, Kraus T, Brümmendorf TH, Ziegler P. Additional benefits of telomere length (TL) measurements in chronic lymphocytic leukemia. Leuk Lymphoma. 2019 Feb;60(2):541-543. doi: 10.1080/10428194.2018.1482544. Epub 2018 Jul 3. No abstract available. PubMed [citation] PMID: 29966475
  • Andert A, Alizai HP, Ulmer TF, Heidenhain C, Ziegler P, Brümmendorf TH, Neumann UP, Beier F, Klink CD. Influence of Telomere Length in Hepatocytes on Liver Regeneration after Partial Hepatectomy in Rats. Eur Surg Res. 2018;59(1-2):83-90. doi: 10.1159/000489090. Epub 2018 Jun 8. PubMed [citation] PMID: 29886505
  • Vasko T, Kaifie A, Stope MB, Kraus T, Ziegler P. Telomeres and Telomerase in Hematopoietic Dysfunction: Prognostic Implications and Pharmacological Interventions. Int J Mol Sci. 2017 Oct 28;18(11). doi: 10.3390/ijms18112267. Review. PubMed [citation] PMID: 29143804, PMCID: PMC5713237
  • Ventura Ferreira MS, Crysandt M, Ziegler P, Hummel S, Wilop S, Kirschner M, Schemionek M, Jost E, Wagner W, Brümmendorf TH, Beier F. Evidence for a pre-existing telomere deficit in non-clonal hematopoietic stem cells in patients with acute myeloid leukemia. Ann Hematol. 2017 Sep;96(9):1457-1461. doi: 10.1007/s00277-017-3049-z. Epub 2017 Jul 3. PubMed [citation] PMID: 28674830
  • Ahrend H, Kaul A, Ziegler S, Brandenburg LO, Zimmermann U, Mustea A, Burchardt M, Ziegler P, Stope MB. MicroRNA-1 and MicroRNA-21 Individually Regulate Cellular Growth of Non-malignant and Malignant Renal Cells. In Vivo. 2017 Jul-Aug;31(4):625-630. PubMed [citation] PMID: 28652429, PMCID: PMC5566912
  • Müller-Newen G, Stope MB, Kraus T, Ziegler P. Development of platelets during steady state and inflammation. J Leukoc Biol. 2017 May;101(5):1109-1117. doi: 10.1189/jlb.1RU0916-391RR. Epub 2017 Feb 24. Review. PubMed [citation] PMID: 28235774
  • Caspar A, Mostertz J, Leymann M, Ziegler P, Evert K, Evert M, Zimmermann U, Brandenburg LO, Burchardt M, Stope MB. In Vitro Cultivation of Primary Prostate Cancer Cells Alters the Molecular Biomarker Pattern. In Vivo. 2016 09-10;30(5):573-9. PubMed [citation] PMID: 27566074
  • Ziegler S, Schettgen T, Beier F, Wilop S, Quinete N, Esser A, Masouleh BK, Ferreira MS, Vankann L, Uciechowski P, Rink L, Kraus T, Brümmendorf TH, Ziegler P. Accelerated telomere shortening in peripheral blood lymphocytes after occupational polychlorinated biphenyls exposure. Arch Toxicol. 2017 Jan;91(1):289-300. doi: 10.1007/s00204-016-1725-8. Epub 2016 May 5. PubMed [citation] PMID: 27146145, PMCID: PMC5225163
  • Weiss M, Ahrend H, Grossebrummel H, Ziegler P, Brandenburg LO, Walther R, Zimmermann U, Burchardt M, Stope MB. Cytochrome P450 17A1 Inhibitor Abiraterone Acetate Counteracts the Heat Shock Protein 27's Cell Survival Properties in Prostate Cancer Cells. Urol Int. 2016;97(1):112-7. doi: 10.1159/000445251. Epub 2016 Mar 24. PubMed [citation] PMID: 27007943
  • Haase H, Fahlenkamp A, Schettgen T, Esser A, Gube M, Ziegler P, Kraus T, Rink L. Immunotoxicity Monitoring in a Population Exposed to Polychlorinated Biphenyls. Int J Environ Res Public Health. 2016 Mar 8;13(3). doi: 10.3390/ijerph13030295. PubMed [citation] PMID: 27005643, PMCID: PMC4808958
  • Rauschenberger L, Staar D, Thom K, Scharf C, Venz S, Homuth G, Schlüter R, Brandenburg LO, Ziegler P, Zimmermann U, Weitschies W, Völker U, Lendeckel U, Walther R, Burchardt M, Stope MB. Exosomal particles secreted by prostate cancer cells are potent mRNA and protein vehicles for the interference of tumor and tumor environment. Prostate. 2016 Mar;76(4):409-24. doi: 10.1002/pros.23132. Epub 2015 Dec 8. PubMed [citation] PMID: 26643154
  • Ziegler P, Boettcher S, Takizawa H, Manz MG, Brümmendorf TH. LPS-stimulated human bone marrow stroma cells support myeloid cell development and progenitor cellmaintenance. Ann Hematol. 2016 Jan;95(2):173-8. doi: 10.1007/s00277-015-2550-5. Epub 2015 Nov 11. PubMed [citation] PMID: 26555286
  • Hummel S, Ventura Ferreira MS, Heudobler D, Huber E, Fahrenkamp D, Gremse F, Schmid K, Müller-Newen G, Ziegler P, Jost E, Blasco MA, Brümmendorf TH, Holler E, Beier F. Telomere shortening in enterocytes of patients with uncontrolled acute intestinal graft-versus-host disease. Blood. 2015 Nov 26;126(22):2518-21. doi: 10.1182/blood-2015-03-633289. Epub 2015 Oct 20. PubMed [citation] PMID: 26486788
  • Beier F, Masouleh BK, Buesche G, Ventura Ferreira MS, Schneider RK, Ziegler P, Wilop S, Vankann L, Gattermann N, Platzbecker U, Giagounidis A, Götze KS, Nolte F, Hofmann WK, Haase D, Kreipe H, Panse J, Blasco MA, Germing U, Brümmendorf TH. Telomere dynamics in patients with del (5q) MDS before and under treatment with lenalidomide. Leuk Res. 2015 Sep 21. pii: S0145-2126(15)30380-5. doi: 10.1016/j.leukres.2015.09.003. [Epub ahead of print] PubMed [citation] PMID: 26427727
  • Wenn K, Tomala L, Wilop S, Vankann L, Hasenbank C, Frank O, Hochhaus A, Giles FJ, Lange T, Müller MC, Koschmieder S, Beier F, Ziegler P, Brümmendorf TH. Telomere length at diagnosis of chronic phase chronic myeloid leukemia (CML-CP) identifies a subgroup with favourable prognostic parameters and molecular response according to the ELN criteria after 12 months of treatment with nilotinib. Leukemia. 2015 Dec;29(12):2402-4. doi: 10.1038/leu.2015.245. Epub 2015 Sep 15. No abstract available. PubMed [citation] PMID: 26369986
  • Weiss M, Gümbel D, Gelbrich N, Brandenburg LO, Mandelkow R, Zimmermann U, Ziegler P, Burchardt M, Stope MB. Inhibition of Cell Growth of the Prostate Cancer Cell Model LNCaP by Cold Atmospheric Plasma. In Vivo. 2015 Sep-Oct;29(5):611-6. PubMed [citation] PMID: 26359422
  • Schumacher A, Denecke B, Braunschweig T, Stahlschmidt J, Ziegler S, Brandenburg LO, Stope MB, Martincuks A, Vogt M, Görtz D, Camporeale A, Poli V, Müller-Newen G, Brümmendorf TH, Ziegler P. Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy. J Hematol Oncol. 2015 Jun 9;8:64. doi: 10.1186/s13045-015-0152-2. PubMed [citation] PMID: 26054961, PMCID: PMC4460974
  • Emontzpohl C, Goetzenich A, Simons D, Kraemer S, Dewor M, Lue H, Hammer L, Jacobs D, Grieb G, Ziegler P, Panse J, Rossaint R, Bernhagen J, Stoppe C. Key role of MIF in the migration of endothelial progenitor cells in patients during cardiac surgery. Int J Cardiol. 2015 Feb 15;181:284-7. doi: 10.1016/j.ijcard.2014.11.226. Epub 2014 Dec 18. No abstract available. PubMed [citation] PMID: 25535692
  • Schneider RK, Ziegler S, Leisten I, Ferreira MS, Schumacher A, Rath B, Fahrenkamp D, Müller-Newen G, Crysandt M, Wilop S, Jost E, Koschmieder S, Knüchel R, Brümmendorf TH, Ziegler P. Activated fibronectin-secretory phenotype of mesenchymal stromal cells in pre-fibrotic myeloproliferative neoplasms. J Hematol Oncol. 2014 Dec 14;7:92. doi: 10.1186/s13045-014-0092-2. PubMed [citation] PMID:  25498831, PMCID: PMC4271470
  • Weidner CI, Ziegler P, Hahn M, Brümmendorf TH, Ho AD, Dreger P, Wagner W. Epigenetic aging upon allogeneic transplantation: the hematopoietic niche does not affect age-associated DNA methylation. Leukemia. 2015 Apr;29(4):985-8. doi: 10.1038/leu.2014.323. Epub 2014 Nov 12. No abstract available. PubMed [citation] PMID: 25388956
  • Stope MB, Stender C, Schubert T, Peters S, Weiss M, Ziegler P, Zimmermann U, Walther R, Burchardt M. Heat-shock protein HSPB1 attenuates microRNA miR-1 expression thereby restoring oncogenic pathways in prostate cancer cells. Anticancer Res. 2014 Jul;34(7):3475-80. PubMed [citation] PMID: 24982356
  • Heuser M, Schlarmann C, Dobbernack V, Panagiota V, Wiehlmann L, Walter C, Beier F, Ziegler P, Yun H, Kade S, Kirchner A, Huang L, Koenecke C, Eder M, Brümmendorf TH, Dugas M, Ganser A, Thol F. Genetic characterization of acquired aplastic anemia by targeted sequencing. Haematologica. 2014 Sep;99(9):e165-7. doi: 10.3324/haematol.2013.101642. Epub 2014 Jun 6. No abstract available. PubMed [citation] PMID: 24907358, PMCID: PMC4562551 Weidner CI, Lin Q, Koch CM, Eisele L, Beier F, Ziegler P, Bauerschlag DO, Jöckel KH, Erbel R, Mühleisen TW, Zenke M, Brümmendorf TH, Wagner W. Aging of blood can be tracked by DNA methylation changes at just three CpG sites. Genome Biol. 2014 Feb 3;15(2):R24. doi: 10.1186/gb-2014-15-2-r24. PubMed [citation] PMID: 24490752, PMCID: PMC4053864
  • Hauber I, Hofmann-Sieber H, Chemnitz J, Dubrau D, Chusainow J, Stucka R, Hartjen P, Schambach A, Ziegler P, Hackmann K, Schröck E, Schumacher U, Lindner C, Grundhoff A, Baum C, Manz MG, Buchholz F, Hauber J. Highly significant antiviral activity of HIV-1 LTR-specific tre-recombinase in humanized mice. PLoS Pathog. 2013;9(9):e1003587. doi: 10.1371/journal.ppat.1003587. Epub 2013 Sep 26. PubMed [citation] PMID: 24086129, PMCID: PMC3784474
  • Stope MB, Rönnau C, Schubert T, Staar D, Bradl J, Ziegler P, Streitbörger A, Kroeger N, Zimmermann U, Walther R, Burchardt M, Börgermann C. [Transforming growth factor β in prostate cancer: cellular effects and basic molecular mechanisms]. Urologe A. 2013 Mar;52(3):378-83. doi: 10.1007/s00120-012-3049-5. German. PubMed [citation] PMID: 23160607
  • Koch CM, Reck K, Shao K, Lin Q, Joussen S, Ziegler P, Walenda G, Drescher W, Opalka B, May T, Brümmendorf T, Zenke M, Saric T, Wagner W. Pluripotent stem cells escape from senescence-associated DNA methylation changes. Genome Res. 2013 Feb;23(2):248-59. doi: 10.1101/gr.141945.112. Epub 2012 Oct 18. PubMed [citation] PMID: 23080539, PMCID: PMC3561866
  • Chatain N, Ziegler P, Fahrenkamp D, Jost E, Moriggl R, Schmitz-Van de Leur H, Müller-Newen G. Src family kinases mediate cytoplasmic retention of activated STAT5 in BCR-ABL-positive cells. Oncogene. 2013 Aug 1;32(31):3587-97. doi: 10.1038/onc.2012.369. Epub 2012 Aug 27. PubMed [citation] PMID: 22926520
  • Boettcher S, Ziegler P, Schmid MA, Takizawa H, van Rooijen N, Kopf M, Heikenwalder M, Manz MG. Cutting edge: LPS-induced emergency myelopoiesis depends on TLR4-expressing nonhematopoietic cells. J Immunol. 2012 Jun 15;188(12):5824-8. doi: 10.4049/jimmunol.1103253. Epub 2012 May 14. PubMed [citation] PMID: 22586037
  • Ziegler P, Schrezenmeier H, Akkad J, Brassat U, Vankann L, Panse J, Wilop S, Balabanov S, Schwarz K, Martens UM, Brümmendorf TH. Telomere elongation and clinical response to androgen treatment in a patient with aplastic anemia and a heterozygous hTERT gene mutation. Ann Hematol. 2012 Jul;91(7):1115-20. doi: 10.1007/s00277-012-1454-x. Epub 2012 Apr 4. PubMed [citation] PMID: 22476886
  • Ziegler P, Chahoud T, Wilhelm T, Pällman N, Braig M, Wiehle V, Ziegler S, Schröder M, Meier C, Kolodzik A, Rarey M, Panse J, Hauber J, Balabanov S, Brümmendorf TH. Evaluation of deoxyhypusine synthase inhibitors targeting BCR-ABL positive leukemias. Invest New Drugs. 2012 Dec;30(6):2274-83. doi: 10.1007/s10637-012-9810-1. Epub 2012 Mar 14. PubMed [citation] PMID: 22415796
  • Leisten I, Kramann R, Ventura Ferreira MS, Bovi M, Neuss S, Ziegler P, Wagner W, Knüchel R, Schneider RK. 3D co-culture of hematopoietic stem and progenitor cells and mesenchymal stem cells in collagen scaffolds as a model of the hematopoietic niche. Biomaterials. 2012 Feb;33(6):1736-47. doi: 10.1016/j.biomaterials.2011.11.034. Epub 2011 Dec 1. PubMed [citation] PMID: 22136713
  • Ziegler P, Teller S, Ha NH, Giese B, Fraunholz M, Walther R. Phosphoproteomic identification of a PDX-1/14-3-3ε interaction in pancreatic beta cells. Horm Metab Res. 2011 Mar;43(3):165-70. doi: 10.1055/s-0030 1270526. Epub 2011 Feb 1. PubMed [citation] PMID: 21287435
  • Neagu MR, Ziegler P, Pertel T, Strambio-De-Castillia C, Grütter C, Martinetti G,  Mazzucchelli L, Grütter M, Manz MG, Luban J. Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components. J Clin Invest. 2009 Oct;119(10):3035-47. doi: 10.1172/JCI39354. Epub 2009 Sep 8. PubMed [citation] PMID: 19741300, PMCID: PMC2752079
  • Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, Debarry J, de Jong Y, Deng H, Di Santo JP, Eisenbarth S, Eynon E, Flavell RA, Guzman CA, Huntington ND, Kremsdorf D, Manns MP, Manz MG, Mention JJ, Ott M, Rathinam C, Rice CM, et al. Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host Microbe. 2009 Jul 23;6(1):5-9. doi: 10.1016/j.chom.2009.06.006. Review. PubMed [citation] PMID: 19616761, PMCID: PMC7038630
  • Martinez Soria N, Tussiwand R, Ziegler P, Manz MG, Heidenreich O. Transient depletion of RUNX1/RUNX1T1 by RNA interference delays tumour formation in vivo. Leukemia. 2009 Jan;23(1):188-90. doi: 10.1038/leu.2008.157. Epub 2008 Jun 12. No abstract available. PubMed [citation] PMID: 18548094
  • Baenziger S, Ziegler P, Mazzucchelli L, Bronz L, Speck RF, Manz MG. Human T cell development and HIV infection in human hemato-lymphoid system mice. Curr Top Microbiol Immunol. 2008;324:125-31. Review. PubMed [citation] PMID: 18481457
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