Dr. rer. nat. Thomas Schettgen

Kurzbiographie

Ausbildung

• 1999-2005  Dr. rer. nat., Universität Erlangen-Nürnberg
• 1992-1998  Staatl. gepr. Lebensmittelchemiker, Universität Kaiserslautern

Beruflicher Werdegang

• seit 2006 Leiter des analytisch-toxikologischen Labors am Institut für Arbeits- und Sozialmedizin der RWTH Aachen
• 2004-2005 wiss. Sekretär der Arbeitsgruppe "Analysen in biologischem Material" der Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe der DFG
• 1999-2004 wiss. Mitarbeiter, Institut für Arbeits-, Sozial- und Umweltmedizin Universität Erlangen-Nürnberg

Forschungsschwerpunkte

• Humanbiomonitoring, u.a.
• Mercaptursäuren und Hämoglobin-Addukte kanzerogener Arbeitsstoffe
• Polychlorierte Biphenyle
• Perfluorierte Verbindungen (PFOA/PFOS)
• Aromatische Diamine und Aromatische Amine
• etc.

Publikationen

T. Schettgen, J. Bertram, T. Kraus (2012). Accurate quantification of the mercapturic acids of acrylonitrile and its genotoxic metabolite cyanoethylene-epoxide in human urine by isotope-dilution LC-ESI/MS/MS. Talanta 98: 211-219.

T. Schettgen, A. Alt, A. Esser, M. Gube, T. Kraus (2012). Plasma PCB levels of workers of a transformer recycling company, their family members and employees of surrounding companies. J Toxicol Environ Health A 75 (8-10): 414-422.

N. Kaesler, T. Schettgen, V.P. Mutucumarana, V. Brandenburg, W. Jahnen-Dechent, L.J. Schurgers, T. Krüger (2012). A fluorescent method to determine Vitamin-K-dependent gamma-glutamyl carboxylase activity. Anal Biochem 421 (2): 411-416.

T. Schettgen, A. Alt, D. Preim, D. Keller, T. Kraus (2012). Biological monitoring of indoor exposure to dioxin-like and non-dioxin-like polychlorinated biphenyls (PCB) in a public building. Toxicol Letters 213:116-121.

J. Hennen, P. Aeby, C. Goebel, T. Schettgen, A. Oberli, M. Kalmes, B. Blömeke (2011). Cross talk between keratinocytes and dendritic cells: impact on the prediction of sensitization. Toxicol Sci 123 (2): 501-510.

T. Schettgen, M. Gube, A. Alt, H. Fromme, J. Angerer, T. Kraus (2011). Pilot study on the exposure of the German general population to non-dioxin-like and dioxin-like PCBs. Int J Hyg Environ Health 214 (4): 319-325.

T. Schettgen, K. Heinrich, T. Kraus, M. Gube (2011). Determination of 2,5-toluylenediamine (2,5-TDA) and aromatic amines in urine after personal application of hair dyes – kinetics and doses.
Arch Toxicol  85 (2):127-133 (2011).

M. Gube, K. Heinrich, P. Dewes, P. Brand, T. Kraus, T. Schettgen (2011). Internal exposure of hairdressers to permanent hair dyes – a biomonitoring study using aromatic diamines as biomarkers of exposure. Int Arch Occup Environ Health 84 (3): 287-292.

M. Reska, E. Ochsmann, T. Kraus, T. Schettgen (2010). Accurate quantification of mercapturic acids of styrene (PHEMAs) in human urine with direct sample injection using automated column-switching high-performance liquid chromatography coupled to tandem mass spectrometry. Anal Bioanal Chem 397 (8), 3563-3574.

T. Schettgen, E. Ochsmann, A. Alt, T. Kraus (2010). A biomarker approach to estimate the internal exposure to benzene in non-smoking and smoking individuals in Germany. J Expo Sci Environ Epidemiol 20 (5), 427-433 (2010).

K. Sterz, D. Köhler, T. Schettgen, G. Scherer (2010). Enrichment and characterization of urinary pre-S-phenylmercapturic acid (pre-S-PMA). J Chromatogr B, 878 (27), 2502-2505.

T. Schettgen, J. Müller, H. Fromme, J. Angerer (2010). Simultaneous quantification of haemoglobin adducts of ethylene oxide, propylene oxide, acrylonitrile, acrylamide and glycidamide using isotope-dilution GC/NCI-MS/MS. J Chromatogr B, 878 (27), 2467-2473.

M. Gube, P. Brand, A. Conventz, J. Ebel, T. Göen, K. Holzinger, A. Müller-Lux, U. Reisgen, T. Schettgen, T. Kraus (2009). Spirometry, Impulse Oscillometry and Capnovolumetry in welders and healthy male subjects. Respir Med 103 (9), 1350 – 1357.

I.M. Carvalho-Oliveira, N.A. Charro, J. Aarbiou, R.M. Buijs-Offerman, M. Wilke, T. Schettgen, T. Kraus, M. Titulaer, P. Burgers, T. Luider, D. Penque, B. Scholte (2009). Proteomic analysis of naphthalene-induced airway epithelial injury and repair in a cystic fibrosis mouse model.
J Proteome Res 8 (7), 3606 – 3616.

B. Kütting, T. Schettgen, U. Schwegler, H. Fromme, W. Uter, J. Angerer, H. Drexler (2009). Acrylamide as environmental noxious agent: a health risk assessment for the general population based on the internal acryamide burden. Int J Hyg Environ Health 212 (5), 470 – 480.

T. Schettgen, A. Musiol, A. Alt, E. Ochsmann, T. Kraus (2009). A method for the simultaneous quantification of the mercapturic acids of acrylonitrile and 1,3-butadiene in human urine by column-switching liquid chromatography – tandem mass spectrometry. Anal Bioanal Chem 393 (3), 969 – 981.

T. Schettgen, A. Musiol, A. Alt, T. Kraus (2008). Fast determination of urinary S-phenylmercapturic acid (S-PMA) and S-benzylmercapturic acid (S-BMA) by column-switching liquid chromatography tandem-mass spectrometry. J Chromatogr B 863(2), 283 – 292.

T. Schettgen, A. Musiol, T. Kraus (2008). Simultaneous determination of mercapturic acids derived from ethylene oxide (HEMA), propylene oxide (2-HPMA), acroleine (3-HPMA), acrylamide (AAMA) and N,N-dimethylformamide (AMCC) in human urine using liquid chromatography /tandem mass spectrometry. Rapid Comm Mass Spectrom 22(17), 2629-2638.

H.C. Broding, T. Schettgen, A. Hillert, J. Angerer, T. Göen, H. Drexler (2008). Subjective complaints in persons under chronic low-dose exposure to lower polychlorinated biphenyls (PCBs). Int J Hyg Environ Health 211(5-6), 648-657.

E. Hartmann, M.I. Böttcher, T. Schettgen, H. Fromme, H. Drexler, J. Angerer (2008). Hemoglobin adducts and mercapturic acid excretion of acrylamide and glycidamide in one study population. J Agric Food Chem, 56, 6061-6068.

T. Schettgen, A. Tings, C. Brodowsky, A. Müller-Lux, A. Musiol, T. Kraus (2007). Simultaneous determination of the advanced glycation endproduct N-ε-carboxymethyllysine and its precursor lysine in exhaled breath condensate using isotope-dilution-hydrophilic-interaction liquid chromatography coupled to tandem mass-spectrometry. Anal Bioanal Chem 387(8), 2783 – 279.

H.C. Broding, T. Schettgen, T. Göen, J. Angerer, H. Drexler (2007). Development and verification of a toxicokinetic model of polychlorinated biphenyl elimination in persons working in a contaminated building. Chemosphere, 68(8), 1427 – 1434.

A. Conventz, A. Musiol, C. Brodowsky, A. Müller-Lux, P. Dewes, T. Kraus, T. Schettgen (2007). Simultaneous determination of 3-nitrotyrosine, tyrosine, hydroxyproline and proline in exhaled breath condensate using isotope-dilution-hydrophilic-interaction liquid chromatography coupled to tandem mass spectrometry. J Chromatogr B, 860(1): 78 – 85.

O. Midasch, T. Schettgen, J. Angerer (2006). Pilot study on the perfluorooctanesulfonate and perfluorooctanoate exposure of the German general population. Int J Hyg Environ Health 209(6), 489 – 496.