Molecular Tumor Biology

Welcome to the research group „Molecular Tumor Biology“!

We focus on the molecular and cell biological mechanisms that govern the pathogenesis of solid tumors in the gastrointestinal and hepatobiliary tract. The whole spectrum of malignant progression is of interest to us, from tumor initiation to local tumor growth, systemic dissemination to therapy resistance. In addition, we are analyzing whole organism effects of tumor formation, such as sarcopenia and cachexia, as these are of central importance for the quality of life of affected patients. Specific topics are nutrition, the tumor microenvironment (e.g. lack of oxygen (hypoxia)), chronic inflammation and tumor-specific metabolic reprogramming. Besides basic research, we are performing translational projects to address the effects of nutritional modifications (e.g. fasting and dietary carbohydrate restriction) on cancer progression and therapy efficacy. We make use of a comprehensive setting of well-established as well as innovative scientific methods. We apply a multicolored spectrum of methods and techniques ranging from murine models and cell culture work to the analysis of tissue and blood samples from affected patients. This approach enables us to combine basic research with translational and applied aspects of science. Our group is young, dynamic, international, well embedded, highly collaborative and based on a genuine fascination for science. I very much hope that you will find these sites helpful!

Best regards,

Thorsten Cramer