liver disease, already affects 30-40% of the Western population and is expected to become the leading cause of liver failure in Western countries. The pathophysiological hallmark of MASLD is excessive lipid
immune system and inflammatory processes. Consequently, dysfunctions in these signalling pathways cause serious defects such as chronic inflammation, insufficient immunity or cancer. As proper functioning
H, Jankowski J, Lebherz C, Boor P, Marx N and Lehrke M. 2,8-Dihydroxyadenine-induced nephropathy causes hexosylceramide accumulation with increased mTOR signaling, reduced levels of protective SirT3 expression [...] H, Jankowski J, Lebherz C, Boor P, Marx N and Lehrke M. 2,8-Dihydroxyadenine-induced nephropathy causes hexosylceramide accumulation with increased mTOR signaling, reduced levels of protective SirT3 expression
PCLS can be found in all species. Across species, we found marked differences . Capsaicin (10 µM) caused bronchoconstriction in human and guinea pig lungs only, indicating excitatory non-adrenergic non [...] 5. Allergic response in PCLS 1.5. Allergic response in PCLS The early allergic response (EAR) is caused by the degranulation of sensitized mast cells. We also tested if allergens are capable to trigger [...] breakdown of sphingomyelin to ceramide and phosphorylcholine in the ceramide generation. Its deficency causes lipid storage diseases, Niemann-Pick-disease (NPD) type A (neuronopathic) and B (non-neuronopathic)
mediators by means of preclinical and clinical approaches, (B) the identification of the mechanisms that cause the effects of these mediators, and (C) the translational transfer and validation of new biomarkers
actual Therapies Project Background: Cancer and actual Therapies Cancer is the second most common cause of death in the world today (WHO world cancer report 2014: 8.2 million cancer related deaths per year) [...] electroporation entails an electrical current flux through the tissue which can be high enough to cause a noticeable temperature increase, even though it is intended to be a non-thermal treatment. The analysis
incorrectly applied in the field. Reasons for this include the distraction and psychological pressure caused by the acute situation. In order to improve the quality of the inspection, the FALKE project aims
central role in the development of new treatments, improvement of therapies, and exploration of the causes of diseases. Particularly in genetics, patient care and research are closely intertwined. For research
pressure break down and leaky vessels resulting in oedema. Imbalanced endothelial function is the major cause of shock ultimately resulting in organ dysfunction and death. Early identification of an imbalance
Systemic administration of drugs with nucleic acid as active compound inevitably result in side effects caused by off-target effects. Our groups studies novel carrier types that enable an activation of therapeutic [...] Overnutrition and obesity represent a worldwide burden for the health systems. Furthermore, genetically caused disorders can lead to liver disease and affect other organ systems. Our institute (group of Prof