leukemic transformation, but the causes are largely unknown. Recent work by our consortium has shown that Gli1+ mesenchymal stromal cells (MSC) are precursors of fibrosis-causing myofibroblasts in the bone marrow
Current research focus on computational methods to understand how cellular microenvironment changes cause or support diseases as kidney fibrosis, myeloproliferative neoplasms and type 2 diabetes by integrative
study to investigate the efficacy and safety of NT 201 in the treatment of lower limb spasticity caused by stroke or traumatic brain injury in adult subjects followed by an open label extension with or
funding will support a detailed analysis of the mechanisms that facilitate bacterial infection and cause organ dysfunction and damage. This project aims at a better understanding of the microbial pathogenesis
important causative agent of gastroenteritis worldwide. In developing countries, EPEC constitutes a major cause of infant mortality. Together with the human pathogen enterohämorrhagic E. coli (EHEC) and the murine [...] (A/E) bacteria. These bacteria are able to intimately attach to the intestinal epithelium, thereby causing an alteration of the mucosal homeostasis and diarrhea. In this work Dupont et al., demonstrate the
disease is a common worldwide health burden with increasing incidence. Chronic hepatocyte injury caused by chronic viral hepatitis, excessive alcohol consumption or accumulation of nutritional fat in the [...] function. Moreover, these processes favor the development of hepatocellular carcinoma, the third leading cause of cancer-related death worldwide. Our group focus on analysing the complex interactions between liver
Robert Dzhanaev Atherosclerosis leading to ischemic heart disease remains the major cause of death worldwide. It is suggested by a number of studies that arterial microcalcification is one of the earliest
Fetuin-A-based theranostics Arteriosclerosis leading to ischemic heart disease remains the major cause of death worldwide. It is suggested by a number of studies that arterial microcalcification is one
you interested in the causes of unusual clinical pictures, complex symptom constellations and rare diseases? Then attend this event and join us in identifying the molecular causes of rare genetic syndromes [...] qualification profile Molecular Medicine. The aim of this qualification profile is to understand the causes of diseases at a molecular and cell biological level, to research their significance for modern medicine [...] sequencing. You will learn to understand the difference between normal genetic variance and disease-causing changes and try your hand at solving real patient cases. Improve your expertise, combination skills
acid-sensing ion channel 1a/2a is broadly expressed in the brain and it has been shown that its blockade causes strong analgesia. In our paper "Acid-sensing ion channel (ASIC) 1a/2a heteromers have a flexible