their treatment duration and prolong lives in many cases. However, adverse drug effects can also cause reversible or irreversible, sometimes even life-threatening damages. Unfortunately, treatment of those
mit seltenen Erbkrankheiten, wie die Studie „C2orf69 mutations disrupt mitochondrial function and cause a multisystem human disorder with recurring autoinflammation“ belegt. Im Rahmen sogenannter Trio- [...] Investigation (JCI) publiziert. Originalpublikation: C2orf69 mutations disrupt mitochondrial function and cause a multisystem human disorder with recurring autoinflammation. Lausberg E , Gießelmann S , Dewulf JP
R-like endoplasmic reticulum kinase (PERK). We report that ER stress combined with ISR inhibition causes an impaired maturation of several tyrosine kinase receptors (RTKs), consistent with a partial block
Project number 425908322 DFG research grant ”ATL gene family: How mutations in ER-shaping proteins cause axonopathy” Applicants: Ch. Kaether (Jena), I. Kurth (Aachen), J. Weis (Aachen) Duration 2022-2025
Cerebellum. J Neurosci 2015; 35:8701-8717. Di Fonzo A, Dekker MC, Montagna P et al. FBXO7 mutations cause autosomal recessive, early-onset parkinsonian-pyramidal syndrome. Neurology 2009; 72:240-245. Yal [...] mutations. Mov Disord 2010. Lohmann E, Coquel AS, Honore A et al. A new F-box protein 7 gene mutation causing typical Parkinson's disease. Mov Disord 2015; 30:1130-1133.
process engineering, medicine and mechanical engineering. Given the increasing number of infections caused by multi-drug resistant bacteria, Patricia Blum addressed in her master’s thesis a very important
voltage-gated sodium, potassium and calcium channels. Such so-called ion channelopathies might be caused by 1) mutations (genetic epilepsies) or by 2) expression changes (acquired epilepsies). In our group
can gain knowledge about how drugs act in different persons and which molecular risk profiles can cause adverse drug reactions. Many advanced therapy approaches no longer consist of a single drug but are
enterica, rotavirus, enteropathogenic E. coli (EPEC) and Listeria monocytogenes. These microorganisms cause a significant morbidity and – particularly in the pediatric population – also a significant mortality
sessions. Here the participants have the chance to talk about their anxieties, to work on the roots and causes of their problems and to develop new perspectives in a secure environment. The group counselling