Stemmler, M. Quiding-Jarbrink, and A. Izcue, Tumour-associated changes in intestinal epithelial cells cause local accumulation of KLRG1+ GATA3+ regulatory T cells in mice. Immunology, 2017. 152(1): p. 74-88
MPN Most BCR-ABL negative MPN patients harbor one of three mutually exclusive driving mutations causing the respective disease. 60% of patients with PMF harbor the JAK2V617F mutation, approximately 30% [...] domain to remain active [7]. This results in altered JAK-STAT signalling and is the most frequent cause for the development of a classical MPN [6]. Alternatively, mutations in exon 12 of JAK2 may be found
reaction in the body, which becomes chronic on repeated contact with the hazardous substance and can cause pulmonary or cardiovascular disease after many years. In order to identify early inflammatory reactions [...] inflammation. • Health effects A variety of procedures can be used to check whether a hazardous substance causes acute impairment of lung function. In addition to classical spirometry, body plethysmography, pulse
Publikationen – Humangenetische Beratungen in der Uniklinik RWTH Aachen
nose and/or throat, skin irritation, and nervous system associated symptoms. Additional stress is caused by thermal, visual, acoustic and/or olfactory stimuli outside individual comfort zones, which vary
Trimethylamine N-oxide (TMAO) and ADP-induced platelet reactivity are independent risk factors for all-cause and cardiovascular mortality. Circ Res 2020;126(5):660-662 King RJ*, Schuett K *, Tiede C, Jankowski
Treutlein J, Rietschel M, Shah NJ, Kircher T. A Neuregulin-1 schizophrenia susceptibility variant causes perihippocampal fiber tract anomalies in healthy young subjects. Brain Behav 2014; 4(2): 215-26. [...] Kunert HJ, Herpertz-Dahlmann B, Grözinger M. Psychiatric symptoms in a patient with Wolfram syndrome caused by a combination of thalamic deficit and endocrinological pathologies. Neurocase 2008; 17: 1-6. Arslan
(SPI)1-dependent enterocyte invasion and the generation of intraepithelial microcolonies. Salmonella caused a potent epithelial innate immune activation that required cellular invasion and was mediated by [...] susceptibility during the postnatal period after vaginal delivery. Reduced ligand susceptibility was caused by a sustained posttranscriptional down-regulation of epithelial interleukin 1 receptor associated [...] al., 2006). Both proteasomal/lysosomal degradation and microRNA mediated translational repression cause reduced epithelial IRAK1 protein levels after birth (Chassin et al., 2010). In contrast, IRAK1 levels
eCollection 2021.PMID: 34335876 Free PMC article. Lysophosphatidic acid activates nociceptors and causes pain or itch depending on the application mode in human skin. Düll MM, Stengel M, Ries V, Strupf [...] Pain. 2020 Jan;24(1):122-133. doi: 10.1002/ejp.1467. Epub 2019 Aug 27.PMID: 31392805 Methylglyoxal causes pain and hyperalgesia in human through C-fiber activation. Düll MM, Riegel K, Tappenbeck J, Ries
endoplasmic reticulum lead to axonal degeneration: Millions of people suffer from peripheral neuropathies caused by the degeneration of small sensory peripheral nerve fibers, termed small fiber neuropathy (SFN) [...] in patients with vascular diseases (Innovation Fund): Cardiovascular diseases are the most common cause of death in Germany. One of the most common cardiovascular diseases is peripheral arterial occlusive [...] ENISNIP : European Network on Inherited Sensory Neuropathies and Insensitivity to Pain. The molecular cause of genetic painlessness will be further investigated. The methodological approach lies in the field