Publications

Metabolic reprogramming heterogeneity in chronic kidney disease.
Miguel V, Kramann R.
FEBS Open Bio. 2023 Feb 1. doi: 10.1002/2211-5463.13568. Online ahead of print.
PMID: 36723270 Review.

scMEGA: single-cell multi-omic enhancer-based gene regulatory network inference.
Li Z, Nagai JS, Kuppe C, Kramann R, Costa IG.
Bioinform Adv. 2023 Jan 12;3(1):vbad003. doi: 10.1093/bioadv/vbad003. eCollection 2023.
PMID: 36698768 Free PMC article.

Multiomic Spatial Mapping of Myocardial Infarction and Implications for Personalized Therapy.
Schumacher D, Kramann R.
Arterioscler Thromb Vasc Biol. 2023 Feb;43(2):192-202. doi: 10.1161/ATVBAHA.122.318333. Epub 2022 Dec 29.
PMID: 36579644 Review.

Fast model-free standardization and integration of single-cell transcriptomics data.
Xu Y, Kramann R, McCord R, Hayat S.
Res Sq. 2023 Jan 23:rs.3.rs-2485985. doi: 10.21203/rs.3.rs-2485985/v1. Preprint.
PMID: 36747625 Free PMC article. Updated.

Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac Fibrosis.
Lavine K, Amrute J, Luo X, Penna V, Bredemeyer A, Yamawaki T, Yang S, Kadyrov F, Heo G, Shi S, Lee P, Koenig A, Kuppe C, Jones C, Kopecky B, Hayat S, Ma P, Terada Y, Fu A, Furtado M, Kreisel D, Stitziel N, Li CM, Kramann R, Liu Y, Ason B. Res Sq. 2023 Jan 26:rs.3.rs-2402606. doi: 10.21203/rs.3.rs-2402606/v1. Preprint. PMID: 36747878 Free PMC article.

Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form.
Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, Klug M, Schunk SJ, Schmit D, Kramann R, Körbel C, Ampofo E, Laschke MW, Selejan SR, Paschen A, Herter T, Gaul S, Silbernagel G, Sester M, Sester U, Aßmann G, Bals R, Kostner G, Jahnen-Dechent W, Menger MD, Rohrer L, März W, Böhm M, Jankowski J, Kopf M, Latz E, Niemeyer BA, Fliser D, Laufs U, Speer T.
Nat Immunol. 2023 Feb 13. doi: 10.1038/s41590-023-01424-1. Online ahead of print.
PMID: 36781986 No abstract available.

Protocol to analyze bioenergetics in single human induced-pluripotent-stem-cell-derived kidney organoids using Seahorse XF96.
Miguel V, Reimer KC, Galyga AK, Jansen J, Möllmann J, Meyer L, Schneider RK, Kramann R.
STAR Protoc. 2023 Jan 5;4(1):101999. doi: 10.1016/j.xpro.2022.101999. Online ahead of print.
PMID: 36607813 Free PMC article.

Platelet-instructed SPP1⁺ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner.
Hoeft K, Schaefer GJL, Kim H, Schumacher D, Bleckwehl T, Long Q, Klinkhammer BM, Peisker F, Koch L, Nagai J, Halder M, Ziegler S, Liehn E, Kuppe C, Kranz J, Menzel S, Costa I, Wahida A, Boor P, Schneider RK, Hayat S, Kramann R. Cell Rep. 2023 Feb 17;42(2):112131. doi: 10.1016/j.celrep.2023.112131. Online ahead of print. PMID: 36807143 Free PMC article.

Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells.
Eymael J, van den Broek M, Miesen L, Monge VV, van den Berge BT, Mooren F, Velez VL, Dijkstra J, Hermsen M, Bándi P, Vermeulen M, de Wildt S, Willemsen B, Florquin S, Wetzels R, Steenbergen E, Kramann R, Moeller M, Schreuder MF, Wetzels JF, van der Vlag J, Jansen J, Smeets B.
J Pathol. 2023 Feb;259(2):149-162. doi: 10.1002/path.6029. Epub 2022 Dec 19.
PMID: 36373978

Comparative assessment of coronary physiology using transthoracic pulsed-wave Doppler and myocardial contrast echocardiography in rats.
Billig S, Hein M, Mechelinck M, Schumacher D, Roehl AB, Fuchs D, Kramann R, Uhlig M.
Eur Radiol Exp. 2023 Feb 9;7(1):6. doi: 10.1186/s41747-022-00319-4.
PMID: 36757486 Free PMC article.

Sublethal necroptosis signaling promotes inflammation and liver cancer.
Vucur M, Ghallab A, Schneider AT, Adili A, Cheng M, Castoldi M, Singer MT, Büttner V, Keysberg LS, Küsgens L, Kohlhepp M, Görg B, Gallage S, Barragan Avila JE, Unger K, Kordes C, Leblond AL, Albrecht W, Loosen SH, Lohr C, Jördens MS, Babler A, Hayat S, Schumacher D, Koenen MT, Govaere O, Boekschoten MV, Jörs S, Villacorta-Martin C, Mazzaferro V, Llovet JM, Weiskirchen R, Kather JN, Starlinger P, Trauner M, Luedde M, Heij LR, Neumann UP, Keitel V, Bode JG, Schneider RK, Tacke F, Levkau B, Lammers T, Fluegen G, Alexandrov T, Collins AL, Nelson G, Oakley F, Mann DA, Roderburg C, Longerich T, Weber A, Villanueva A, Samson AL, Murphy JM, Kramann R, Geisler F, Costa IG, Hengstler JG, Heikenwalder M, Luedde T. Immunity. 2023 Jun 12:S1074-7613(23)00234-0. doi: 10.1016/j.immuni.2023.05.017. Online ahead of print. PMID: 37329888

Author Correction: A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology.
Petersen J, Englmaier L, Artemov AV, Poverennaya I, Mahmoud R, Bouderlique T, Tesarova M, Deviatiiarov R, Szilvásy-Szabó A, Akkuratov EE, Pajuelo Reguera D, Zeberg H, Kaucka M, Kastriti ME, Krivanek J, Radaszkiewicz T, Gömöryová K, Knauth S, Potesil D, Zdrahal Z, Ganji RS, Grabowski A, Buhl ME, Zikmund T, Kavkova M, Axelson H, Lindgren D, Kramann R, Kuppe C, Erdélyi F, Máté Z, Szabó G, Koehne T, Harkany T, Fried K, Kaiser J, Boor P, Fekete C, Rozman J, Kasparek P, Prochazka J, Sedlacek R, Bryja V, Gusev O, Adameyko I. Nat Commun. 2023 Jun 15;14(1):3565. doi: 10.1038/s41467-023-39373-w. PMID: 37322005 Free PMC article. No abstract available.

Transformative Materials to Create 3D Functional Human Tissue Models In Vitro in a Reproducible Manner.
Gerardo-Nava JL, Jansen J, Günther D, Klasen L, Thiebes AL, Niessing B, Bergerbit C, Meyer AA, Linkhorst J, Barth M, Akhyari P, Stingl J, Nagel S, Stiehl T, Lampert A, Leube R, Wessling M, Santoro F, Ingebrandt S, Jockenhoevel S, Herrmann A, Fischer H, Wagner W, Schmitt RH, Kiessling F, Kramann R, De Laporte L. Adv Healthc Mater. 2023 Jun 13:e2301030. doi: 10.1002/adhm.202301030. Online ahead of print. PMID: 37311209

Transformative Materials for Interfacial Drug Delivery.
Desai P, Dasgupta A, Sofias AM, Peña Q, Göstl R, Slabu I, Schwaneberg U, Stiehl T, Wagner W, Jockenhövel S, Stingl J, Kramann R, Trautwein C, Brümmendorf TH, Kiessling F, Herrmann A, Lammers T. Adv Healthc Mater. 2023 Jun 6:e2301062. doi: 10.1002/adhm.202301062. Online ahead of print. PMID: 37282805

A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology.
Petersen J, Englmaier L, Artemov AV, Poverennaya I, Mahmoud R, Bouderlique T, Tesarova M, Deviatiiarov R, Szilvásy-Szabó A, Akkuratov EE, Pajuelo Reguera D, Zeberg H, Kaucka M, Kastriti ME, Krivanek J, Radaszkiewicz T, Gömöryová K, Knauth S, Potesil D, Zdrahal Z, Ganji RS, Grabowski A, Buhl ME, Zikmund T, Kavkova M, Axelson H, Lindgren D, Kramann R, Kuppe C, Erdélyi F, Máté Z, Szabó G, Koehne T, Harkany T, Fried K, Kaiser J, Boor P, Fekete C, Rozman J, Kasparek P, Prochazka J, Sedlacek R, Bryja V, Gusev O, Adameyko I. Nat Commun. 2023 May 29;14(1):3092. doi: 10.1038/s41467-023-38663-7. PMID: 37248239 Free PMC article.

MASI enables fast model-free standardization and integration of single-cell transcriptomics data.
Xu Y, Kramann R, McCord RP, Hayat S. Commun Biol. 2023 Apr 28;6(1):465. doi: 10.1038/s42003-023-04820-3. PMID: 37117305 Free PMC article.

Intravenous Sodium Thiosulphate for Calciphylaxis of Chronic Kidney Disease: A Systematic Review and Meta-analysis.
Wen W, Portales-Castillo I, Seethapathy R, Durant O, Mengesha B, Krinsky S, Kroshinsky D, Kalim S, Goverman J, Nazarian RM, Chitalia V, Malhotra R, Kramann R, Malhotra CK, Nigwekar SU. JAMA Netw Open. 2023 Apr 3;6(4):e2310068. doi: 10.1001/jamanetworkopen.2023.10068. PMID: 37099293 Free PMC article.

Mast Cells in Kidney Transplant Biopsies With Borderline T Cell-mediated Rejection and Their Relation to Chronicity.
Varol H, van der Elst G, Baan CC, van Baardwijk M, Hesselink DA, Duong van Huyen JP, Kramann R, Rabant M, van den Bosch TPP, Clahsen-van Groningen MC. Transplant Direct. 2023 Apr 20;9(5):e1480. doi: 10.1097/TXD.0000000000001480. eCollection 2023 May. PMID: 37096153 Free PMC article.

Fibrosis in Pathology of Heart and Kidney: From Deep RNA-Sequencing to Novel Molecular Targets.
Schreibing F, Anslinger TM, Kramann R. Circ Res. 2023 Apr 14;132(8):1013-1033. doi: 10.1161/CIRCRESAHA.122.321761. Epub 2023 Apr 13. PMID: 37053278 Review.

Expansion-enhanced super-resolution radial fluctuations enable nanoscale molecular profiling of pathology specimens.
Kylies D, Zimmermann M, Haas F, Schwerk M, Kuehl M, Brehler M, Czogalla J, Hernandez LC, Konczalla L, Okabayashi Y, Menzel J, Edenhofer I, Mezher S, Aypek H, Dumoulin B, Wu H, Hofmann S, Kretz O, Wanner N, Tomas NM, Krasemann S, Glatzel M, Kuppe C, Kramann R, Banjanin B, Schneider RK, Urbschat C, Arck P, Gagliani N, van Zandvoort M, Wiech T, Grahammer F, Sáez PJ, Wong MN, Bonn S, Huber TB, Puelles VG. Nat Nanotechnol. 2023 Apr;18(4):336-342. doi: 10.1038/s41565-023-01328-z. Epub 2023 Apr 10. PMID: 37037895 Free PMC article.

Magnesium Improves Cardiac Function in Experimental Uremia by Altering Cardiac Elastin Protein Content.
Barros X, Friesen X, Mathias Brandenburg V, Liehn EA, Steppan S, Kiessling F, Kramann R, Floege J, Krüger T, Kaesler N. Nutrients. 2023 Mar 7;15(6):1303. doi: 10.3390/nu15061303. PMID: 36986034 Free PMC article.

IL-6 in the infarcted heart is preferentially formed by fibroblasts and modulated by purinergic signaling.
Alter C, Henseler AS, Owenier C, Hesse J, Ding Z, Lautwein T, Bahr J, Hayat S, Kramann R, Kostenis E, Scheller J, Schrader J. J Clin Invest. 2023 Jun 1;133(11):e163799. doi: 10.1172/JCI163799. PMID: 36943408 Free PMC article.

Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form.
Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, Klug M, Schunk SJ, Schmit D, Kramann R, Körbel C, Ampofo E, Laschke MW, Selejan SR, Paschen A, Herter T, Gaul S, Silbernagel G, Sester M, Sester U, Aßmann G, Bals R, Kostner G, Jahnen-Dechent W, Menger MD, Rohrer L, März W, Böhm M, Jankowski J, Kopf M, Latz E, Niemeyer BA, Fliser D, Laufs U, Speer T. Nat Immunol. 2023 Mar;24(3):412-413. doi: 10.1038/s41590-023-01424-1. Epub 2023 Feb 13. PMID: 36781986 No abstract available.

Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac Fibrosis.
Lavine K, Amrute J, Luo X, Penna V, Bredemeyer A, Yamawaki T, Yang S, Kadyrov F, Heo G, Shi S, Lee P, Koenig A, Kuppe C, Jones C, Kopecky B, Hayat S, Ma P, Terada Y, Fu A, Furtado M, Kreisel D, Stitziel N, Li CM, Kramann R, Liu Y, Ason B. Res Sq. 2023 Jan 26:rs.3.rs-2402606. doi: 10.21203/rs.3.rs-2402606/v1. Preprint. PMID: 36747878 Free PMC article.

Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling.
Schreibing F, Hannani MT, Kim H, Nagai JS, Ticconi F, Fewings E, Bleckwehl T, Begemann M, Torow N, Kuppe C, Kurth I, Kranz J, Frank D, Anslinger TM, Ziegler P, Kraus T, Enczmann J, Balz V, Windhofer F, Balfanz P, Kurts C, Marx G, Marx N, Dreher M, Schneider RK, Saez-Rodriguez J, Costa I, Hayat S, Kramann R.
Front Immunol. 2022 Dec 16;13:1066176. doi: 10.3389/fimmu.2022.1066176. eCollection 2022.
PMID: 36591270 Free PMC article.

Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression.
Sciacovelli M, Dugourd A, Jimenez LV, Yang M, Nikitopoulou E, Costa ASH, Tronci L, Caraffini V, Rodrigues P, Schmidt C, Ryan DG, Young T, Zecchini VR, Rossi SH, Massie C, Lohoff C, Masid M, Hatzimanikatis V, Kuppe C, Von Kriegsheim A, Kramann R, Gnanapragasam V, Warren AY, Stewart GD, Erez A, Vanharanta S, Saez-Rodriguez J, Frezza C.
Nat Commun. 2022 Dec 20;13(1):7830. doi: 10.1038/s41467-022-35036-4.
PMID: 36539415 Free PMC article.

Adult human kidney organoids originate from CD24⁺ cells and represent an advanced model for adult polycystic kidney disease.
Xu Y, Kuppe C, Perales-Patón J, Hayat S, Kranz J, Abdallah AT, Nagai J, Li Z, Peisker F, Saritas T, Halder M, Menzel S, Hoeft K, Kenter A, Kim H, van Roeyen CRC, Lehrke M, Moellmann J, Speer T, Buhl EM, Hoogenboezem R, Boor P, Jansen J, Knopp C, Kurth I, Smeets B, Bindels E, Reinders MEJ, Baan C, Gribnau J, Hoorn EJ, Steffens J, Huber TB, Costa I, Floege J, Schneider RK, Saez-Rodriguez J, Freedman BS, Kramann R.
Nat Genet. 2022 Nov;54(11):1690-1701. doi: 10.1038/s41588-022-01202-z. Epub 2022 Oct 27.
PMID: 36303074

Distinct role of mitochondrial function and protein kinase C in intimal and medial calcification in vitro.
Heuschkel MA, Babler A, Heyn J, van der Vorst EPC, Steenman M, Gesper M, Kappel BA, Magne D, Gouëffic Y, Kramann R, Jahnen-Dechent W, Marx N, Quillard T, Goettsch C.
Front Cardiovasc Med. 2022 Sep 20;9:959457. doi: 10.3389/fcvm.2022.959457. eCollection 2022.
PMID: 36204585 Free PMC article.

Mapping Human Cardiac Sarcoidosis by Single Nuclear and Spatial Profiling.
Hayat S, Kramann R.
Circ Res. 2022 Sep 30;131(8):670-672. doi: 10.1161/CIRCRESAHA.122.321778. Epub 2022 Sep 29.
PMID: 36173822 No abstract available.

Pro-oxidative priming but maintained cardiac function in a broad spectrum of murine models of chronic kidney disease.
Wollenhaupt J, Frisch J, Harlacher E, Wong DWL, Jin H, Schulte C, Vondenhoff S, Moellmann J, Klinkhammer BM, Zhang L, Baleanu-Curaj A, Liehn EA, Speer T, Kazakov A, Werner C, van der Vorst EPC, Selejan SR, Hohl M, Böhm M, Kramann R, Biessen EAL, Lehrke M, Marx N, Jankowski J, Maack C, Boor P, Prates Roma L, Noels H.
Redox Biol. 2022 Oct;56:102459. doi: 10.1016/j.redox.2022.102459. Epub 2022 Aug 30.
PMID: 36099852 Free PMC article.

The SGLT2 inhibitor ertugliflozin modifies the signature of cardiac substrate metabolism and reduces cardiac mTOR-signaling, endoplasmic reticulum stress and apoptosis.
Moellmann J, Mann PA, Kappel BA, Kahles F, Klinkhammer BM, Boor P, Kramann R, Ghesquiere B, Lebherz C, Marx N, Lehrke M.
Diabetes Obes Metab. 2022 Jul 8. doi: 10.1111/dom.14814. Online ahead of print. PMID: 35801343

Mapping the cardiac vascular niche in heart failure.
Peisker F, Halder M, Nagai J, Ziegler S, Kaesler N, Hoeft K, Li R, Bindels EMJ, Kuppe C, Moellmann J, Lehrke M, Stoppe C, Schaub MT, Schneider RK, Costa I, Kramann R.
Nat Commun. 2022 May 31;13(1):3027. doi: 10.1038/s41467-022-30682-0.
PMID: 35641541 Free PMC article.

Intravenous sodium thiosulphate for vascular calcification of hemodialysis patients - a systematic review and meta-analysis. 
Wen W, Portales-Castillo I, Seethapathy R, Krinsky S, Kroshinsky D, Kalim S, Goverman J, Nazarian RM, Chitalia V, Malhotra R, Kramann R, Malhotra CK, Nigwekar SU.
Nephrol Dial Transplant. 2022 May 6:gfac171. doi: 10.1093/ndt/gfac171. Online ahead of print.
PMID: 35521751

Human pluripotent stem cell-derived kidney organoids for personalized congenital and idiopathic nephrotic syndrome modeling.
Jansen J, van den Berge BT, van den Broek M, Maas RJ, Daviran D, Willemsen B, Roverts R, van der Kruit M, Kuppe C, Reimer KC, Di Giovanni G, Mooren F, Nlandu Q, Mudde H, Wetzels R, den Braanker D, Parr N, Nagai JS, Drenic V, Costa IG, Steenbergen E, Nijenhuis T, Dijkman H, Endlich N, van de Kar NCAJ, Schneider RK, Wetzels JFM, Akiva A, van der Vlag J, Kramann R, Schreuder MF, Smeets B.
Development. 2022 May 1;149(9):dev200198. doi: 10.1242/dev.200198. Epub 2022 May 6.
PMID: 35417019 Free PMC article.

Mapping the human kidney using single-cell genomics.
Schreibing F, Kramann R.
Nat Rev Nephrol. 2022 Jun;18(6):347-360. doi: 10.1038/s41581-022-00553-4. Epub 2022 Mar 17.
PMID: 35301441 Review.

Differential Effects of Platelet Factor 4 (CXCL4) and Its Non-Allelic Variant (CXCL4L1) on Cultured Human Vascular Smooth Muscle Cells.
Kaczor DM, Kramann R, Hackeng TM, Schurgers LJ, Koenen RR.
Int J Mol Sci. 2022 Jan 6;23(2):580. doi: 10.3390/ijms23020580.
PMID: 35054772 Free PMC article.

Carbamylated sortilin associates with cardiovascular calcification in patients with chronic kidney disease.
Jankowski V, Saritas T, Kjolby M, Hermann J, Speer T, Himmelsbach A, Mahr K, Heuschkel MA, Schunk SJ, Thirup S, Winther S, Bottcher M, Nyegard M, Nykjaer A, Kramann R, Kaesler N, Jankowski J, Floege J, Marx N, Goettsch C.
Kidney Int. 2022 Mar;101(3):574-584. doi: 10.1016/j.kint.2021.10.018. Epub 2021 Nov 9.
PMID: 34767831

Altered vitamin K biodistribution and metabolism in experimental and human chronic kidney disease.
Kaesler N, Schreibing F, Speer T, Puente-Secades S, Rapp N, Drechsler C, Kabgani N, Kuppe C, Boor P, Jankowski V, Schurgers L, Kramann R, Floege J.
Kidney Int. 2022 Feb;101(2):338-348. doi: 10.1016/j.kint.2021.10.029. Epub 2021 Nov 11.
PMID: 34774554

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids.
Jansen J, Reimer KC, Nagai JS, Varghese FS, Overheul GJ, de Beer M, Roverts R, Daviran D, Fermin LAS, Willemsen B, Beukenboom M, Djudjaj S, von Stillfried S, van Eijk LE, Mastik M, Bulthuis M, Dunnen WD, van Goor H, Hillebrands JL, Triana SH, Alexandrov T, Timm MC, van den Berge BT, van den Broek M, Nlandu Q, Heijnert J, Bindels EMJ, Hoogenboezem RM, Mooren F, Kuppe C, Miesen P, Grünberg K, Ijzermans T, Steenbergen EJ, Czogalla J, Schreuder MF, Sommerdijk N, Akiva A, Boor P, Puelles VG, Floege J, Huber TB; COVID Moonshot consortium, van Rij RP, Costa IG, Schneider RK, Smeets B, Kramann R.
Cell Stem Cell. 2022 Feb 3;29(2):217-231.e8. doi: 10.1016/j.stem.2021.12.010. Epub 2021 Dec 25.
PMID: 35032430 Free PMC article.

A systematic review and meta-analysis of murine models of uremic cardiomyopathy.
Soppert J, Frisch J, Wirth J, Hemmers C, Boor P, Kramann R, Vondenhoff S, Moellmann J, Lehrke M, Hohl M, van der Vorst EPC, Werner C, Speer T, Maack C, Marx N, Jankowski J, Roma LP, Noels H.
Kidney Int. 2022 Feb;101(2):256-273. doi: 10.1016/j.kint.2021.10.025. Epub 2021 Nov 11.
PMID: 34774555

Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion.
von Mässenhausen A, Zamora Gonzalez N, Maremonti F, Belavgeni A, Tonnus W, Meyer C, Beer K, Hannani MT, Lau A, Peitzsch M, Hoppenz P, Locke S, Chavakis T, Kramann R, Muruve DA, Hugo C, Bornstein SR, Linkermann A.
Sci Adv. 2022 Feb 4;8(5):eabl8920. doi: 10.1126/sciadv.abl8920. Epub 2022 Feb 2.
PMID: 35108055 Free PMC article.

New Aspects of Kidney Fibrosis-From Mechanisms of Injury to Modulation of Disease.
Moeller MJ, Kramann R, Lammers T, Hoppe B, Latz E, Ludwig-Portugall I, Boor P, Floege J, Kurts C, Weiskirchen R, Ostendorf T.
Front Med (Lausanne). 2022 Jan 12;8:814497. doi: 10.3389/fmed.2021.814497. eCollection 2021.
PMID: 35096904 Free PMC article. Review.

Implementation of Pericytes in Vascular Regeneration Strategies.
Meijer EM, van Dijk CGM, Kramann R, Verhaar MC, Cheng C.
Tissue Eng Part B Rev. 2022 Feb;28(1):1-21. doi: 10.1089/ten.TEB.2020.0229. Epub 2021 Jan 20.
PMID: 33231500 Review.

Pro-oxidative priming but maintained cardiac function in a broad spectrum of murine models of chronic kidney disease.
Wollenhaupt J, Frisch J, Harlacher E, Wong DWL, Jin H, Schulte C, Vondenhoff S, Moellmann J, Klinkhammer BM, Zhang L, Baleanu-Curaj A, Liehn EA, Speer T, Kazakov A, Werner C, van der Vorst EPC, Selejan SR, Hohl M, Böhm M, Kramann R, Biessen EAL, Lehrke M, Marx N, Jankowski J, Maack C, Boor P, Prates Roma L, Noels H.
Redox Biol. 2022 Aug 30;56:102459. doi: 10.1016/j.redox.2022.102459. Online ahead of print.
PMID: 36099852

Using human iPSC-derived kidney organoids to decipher SARS-CoV-2 pathology on single cell level.
Reimer KC, Jansen J, Overheul GJ, Miesen P, van Rij RP, Triana SH, Smeets B, Schneider RK, Kramann R.
STAR Protoc. 2022 Jul 19;3(3):101612. doi: 10.1016/j.xpro.2022.101612. eCollection 2022 Sep 16.
PMID: 35983169 Free PMC article.

Spatial multi-omic map of human myocardial infarction.
Kuppe C, Ramirez Flores RO, Li Z, Hayat S, Levinson RT, Liao X, Hannani MT, Tanevski J, Wünnemann F, Nagai JS, Halder M, Schumacher D, Menzel S, Schäfer G, Hoeft K, Cheng M, Ziegler S, Zhang X, Peisker F, Kaesler N, Saritas T, Xu Y, Kassner A, Gummert J, Morshuis M, Amrute J, Veltrop RJA, Boor P, Klingel K, Van Laake LW, Vink A, Hoogenboezem RM, Bindels EMJ, Schurgers L, Sattler S, Schapiro D, Schneider RK, Lavine K, Milting H, Costa IG, Saez-Rodriguez J, Kramann R.
Nature. 2022 Aug;608(7924):766-777. doi: 10.1038/s41586-022-05060-x. Epub 2022 Aug 10.
PMID: 35948637 Free PMC article.

Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality.
Schunk SJ, Kleber ME, März W, Pang S, Zewinger S, Triem S, Ege P, Reichert MC, Krawczyk M, Weber SN, Jaumann I, Schmit D, Sarakpi T, Wagenpfeil S, Kramann R, Boerwinkle E, Ballantyne CM, Grove ML, Tragante V, Pilbrow AP, Richards AM, Cameron VA, Doughty RN, Dubé MP, Tardif JC, Feroz-Zada Y, Sun M, Liu C, Ko YA, Quyyumi AA, Hartiala JA, Tang WHW, Hazen SL, Allayee H, McDonough CW, Gong Y, Cooper-DeHoff RM, Johnson JA, Scholz M, Teren A, Burkhardt R, Martinsson A, Smith JG, Wallentin L, James SK, Eriksson N, White H, Held C, Waterworth D, Trompet S, Jukema JW, Ford I, Stott DJ, Sattar N, Cresci S, Spertus JA, Campbell H, Tierling S, Walter J, Ampofo E, Niemeyer BA, Lipp P, Schunkert H, Böhm M, Koenig W, Fliser D, Laufs U, Speer T; eQTLGen consortium; BIOS consortium.
Eur Heart J. 2021 May 7;42(18):1742-1756. doi: 10.1093/eurheartj/ehab107.
PMID: 33748830 Free PMC article.

Guanidinylated Apolipoprotein C3 (ApoC3) Associates with Kidney and Vascular Injury.
Schunk S, Hermann J, Sarakpi T, Triem S, Lellig M, Hahm E, Zewinger S, Schmit D, Becker E, Möllmann J, Lehrke M, Kramann R, Boor P, Lipp P, Laufs U, März W, Reiser J, Jankowski J, Fliser D, Speer T, Jankowski V.
J Am Soc Nephrol. 2021 Sep 29:ASN.2021040503. doi: 10.1681/ASN.2021040503. Online ahead of print.
MID: 34588185

Defining the variety of cell types in developing and adult human kidneys by single-cell RNA sequencing.
Schumacher A, Rookmaaker MB, Joles JA, Kramann R, Nguyen TQ, van Griensven M, LaPointe VLS.
NPJ Regen Med. 2021 Aug 11;6(1):45. doi: 10.1038/s41536-021-00156-w.
PMID: 34381054 Free PMC article. Review.

van Kuijk K, Demandt JAF, Perales-Patón J, Theelen TL, Kuppe C, Marsch E, de Bruijn J, Jin H, Gijbels MJ, Matic L, Mees BME, Reutelingsperger CPM, Hedin U, Biessen EAL, Carmeliet P, Baker AH, Kramann RK, Schurgers LJ, Saez-Rodriguez J, Sluimer JC. DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS VIA MACROPHAGE APOPTOSIS AND PARACRINE FIBROTIC SIGNALING: Atherogenic effects of myeloid PHD knockdown. Cardiovasc Res. 2021 Apr 26:cvab152. doi: 10.1093/cvr/cvab152. Online ahead of print

Zimmermann M, Klaus M, Wong MN, Thebille AK, Gernhold L, Kuppe C, Halder M, Kranz J, Wanner N, Braun F, Wulf S, Wiech T, Panzer U, Krebs CF, Hoxha E, Kramann R, Huber TB, Bonn S, Puelles VG.Deep learning-based molecular morphometrics for kidney biopsies. JCI Insight. 2021 Apr 8;6(7):144779. doi: 10.1172/jci.insight.144779.PMID: 33705360

Schunk SJ, Kleber ME, März W, Pang S, Zewinger S, Triem S, Ege P, Reichert MC, Krawczyk M, Weber SN, Jaumann I, Schmit D, Sarakpi T, Wagenpfeil S, Kramann R, Boerwinkle E, Ballantyne CM, Grove ML, Tragante V, Pilbrow AP, Richards AM, Cameron VA, Doughty RN, Dubé MP, Tardif JC, Feroz-Zada Y, Sun M, Liu C, Ko YA, Quyyumi AA, Hartiala JA, Tang WHW, Hazen SL, Allayee H, McDonough CW, Gong Y, Cooper-DeHoff RM, Johnson JA, Scholz M, Teren A, Burkhardt R, Martinsson A, Smith JG, Wallentin L, James SK, Eriksson N, White H, Held C, Waterworth D, Trompet S, Jukema JW, Ford I, Stott DJ, Sattar N, Cresci S, Spertus JA, Campbell H, Tierling S, Walter J, Ampofo E, Niemeyer BA, Lipp P, Schunkert H, Böhm M, Koenig W, Fliser D, Laufs U, Speer T; eQTLGen consortium‡; BIOS consortium‡. Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality. Eur Heart J. 2021 Mar 22:ehab107. doi: 10.1093/eurheartj/ehab107. Online ahead of print.PMID: 33748830

Meijer, EM,van Dijk, CGM,Kramann, R,Verhaar, MC,Cheng, C. Implementation of Pericytes in Vascular Regeneration Strategies. Tissue Eng Part B Rev. 2021

Dugourd, A,Kuppe, C,Sciacovelli, M,Gjerga, E,Gabor, A,Emdal, KB,Vieira, V,Bekker-Jensen, DB,Kranz, J,Bindels, EMJ,Costa, ASH,Sousa, A,Beltrao, P,Rocha, M,Olsen, JV,Frezza, C,Kramann, R,Saez-Rodriguez, J. Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses. Mol Syst Biol 2021
PMID: 33502086

Kuppe, C.,Ibrahim, M. M.,Kranz, J.,Zhang, X.,Ziegler, S.,Perales-Paton, J.,Jansen, J.,Reimer, K. C.,Smith, J. R.,Dobie, R.,Wilson-Kanamari, J. R.,Halder, M.,Xu, Y.,Kabgani, N.,Kaesler, N.,Klaus, M.,Gernhold, L.,Puelles, V. G.,Huber, T. B.,Boor, P.,Menzel, S.,Hoogenboezem, R. M.,Bindels, E. M. J.,Steffens, J.,Floege, J.,Schneider, R. K.,Saez-Rodriguez, J.,Henderson, N. C.,Kramann, R. Decoding myofibroblast origins in human kidney fibrosis. Nature 2021, 589, 281-286

Kuppe, C.,Perales-Paton, J.,Saez-Rodriguez, J.,Kramann, R. Experimental and computational technologies to dissect the kidney at the single-cell level. Nephrol Dial Transplant 2021

Bouteldja, N.,Klinkhammer, B.M.,Bülow, R.D. Droste, P.,Otten, S.W.,Freifrau von Stillfried, S.,Moellmann, J.,Sheehan, S.M.,Korstanje, R.,Menzel, S.,Bankhead, P.,Mietsch, M.,Drummer, C.,Lehrke, M.,Kramann, R.,Floege, J.,Boor, P.,Merhof, D. Deep Learning-Based Segmentation and Quantification in experimental Kidney Histopathology. J Am Soc Nephrol. 2021, 32, 52-68

Kramann R, Menzel S. Mouse Models of Kidney Fibrosis. Methods Mol Biol. 2021;2299:323-338. doi: 10.1007/978-1-0716-1382-5_22.
PMID: 34028752

Saritas T, Kramann R. Kidney Allograft Fibrosis: Diagnostic and Therapeutic Strategies. Transplantation. 2021 Feb 8. doi: 10.1097/TP.0000000000003678. Online ahead of print.PMID: 33982910

Terhuerne J, van Diepen M, Kramann R, Erpenbeck J, Dekker F, Marx N, Floege J, Becker M, Schlieper G. Clin Kidney J. Speckle-tracking echocardiography in comparison with ejection fraction for prediction of cardiovascular mortality in patients with end-stage renal disease. 2021 Jan 19;14(6):1579-1585. doi: 10.1093/ckj/sfaa161. eCollection 2021 Jun. PMID: 34276976

Tonnus W, Meyer C, Steinebach C, Belavgeni A, von Mässenhausen A, Gonzalez NZ, Maremonti F, Gembardt F, Himmerkus N, Latk M, Locke S, Marschner J, Li W, Short S, Doll S, Ingold I, Proneth B, Daniel C, Kabgani N, Kramann R, Motika S, Hergenrother PJ, Bornstein SR, Hugo C, Becker JU, Amann K, Anders HJ, Kreisel D, Pratt D, Gütschow M, Conrad M, Linkermann A. Nat Commun. Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury.  2021 Jul 20;12(1):4402. doi: 10.1038/s41467-021-24712-6. PMID: 34285231

Boehnke J, Atakhanov S, Toledo MAS, Schüler HM, Sontag S, Chatain N, Koschmieder S, Brümmendorf TH, Kramann R, Zenke M. Stem Cell Res. CRISPR/Cas9 mediated CXCL4 knockout in human iPS cells of polycythemia vera patient with JAK2 V617F mutation. 2021 Aug 5;55:102490. doi: 10.1016/j.scr.2021.102490. Online ahead of print. PMID: 34391098

Jaminon AMG, Akbulut AC, Rapp N, Kramann R, Biessen EAL, Temmerman L, Mees B, Brandenburg V, Dzhanaev R, Jahnen-Dechent W, Floege J, Uitto J, Reutelingsperger CP, Schurgers LJ. Cells. Development of the BioHybrid Assay: Combining Primary Human Vascular Smooth Muscle Cells and Blood to Measure Vascular Calcification Propensity.  2021 Aug 16;10(8):2097. doi: 10.3390/cells10082097. PMID: 34440866

Schunk SJ, Triem S, Schmit D, Zewinger S, Sarakpi T, Becker E, Hütter G, Wrublewsky S, Küting F, Hohl M, Alansary D, Prates Roma L, Lipp P, Möllmann J, Lehrke M, Laschke MW, Menger MD, Kramann R, Boor P, Jahnen-Dechent W, März W, Böhm M, Laufs U, Niemeyer BA, Fliser D, Ampofo E, Speer T. Circulation. Interleukin-1α (IL-1α) is a Central Regulator of Leukocyte-Endothelial Adhesion in Myocardial Infarction and in Chronic Kidney Disease. 2021 Jul 1. doi: 10.1161/CIRCULATIONAHA.121.053547. Online ahead of print. PMID: 34192892

Zewinger, S.,Reiser, J.,Jankowski, V.,Alansary, D.,Hahm, E.,Triem, S.,Klug, M.,Schunk, S. J.,Schmit, D.,Kramann, R.,Körbel, C.,Ampofo, E.,Laschke, M. W.,Selejan, S. R.,Paschen, A.,Herter, T.,Schuster, S.,Silbernagel, G.,Sester, M.,Sester, U.,Aßmann, G.,Bals, R.,Kostner, G.,Jahnen-Dechent, W.,Menger, M. D.,Rohrer, L.,März, W.,Böhm, M.,Jankowski, J.,Kopf, M.,Latz, E.,Niemeyer, B. A.,Fliser, D.,Laufs, U.,Speer, T. Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation. Nat Immunol 2020, 21, 30-41.

Tajti, F.,Kuppe, C.,Antoranz, A.,Ibrahim, M. M.,Kim, H.,Ceccarelli, F.,Holland, C. H.,Olauson, H.,Floege, J.,Alexopoulos, L. G.,Kramann, R.,Saez-Rodriguez, J. A Functional Landscape of CKD Entities From Public Transcriptomic Data. Kidney Int Rep 2020, 5, 211-224.

Sellmayr, M.,Hernandez Petzsche, M. R.,Ma, Q.,Krüger, N.,Liapis, H.,Brink, A.,Lenz, B.,Angelotti, M. L.,Gnemmi, V.,Kuppe, C.,Kim, H.,Bindels, E. M. J.,Tajti, F.,Saez-Rodriguez, J.,Lech, M.,Kramann, R.,Romagnani, P.,Anders, H. J.,Steiger, S. Only Hyperuricemia with Crystalluria, but not Asymptomatic Hyperuricemia, Drives Progression of Chronic Kidney Disease. J Am Soc Nephrol 2020.

Lanzer, J. D.,Leuschner, F.,Kramann, R.,Levinson, R. T.,Saez-Rodriguez, J. Big Data Approaches in Heart Failure Research. Curr Heart Fail Rep 2020, 17, 213-224.

Kuppe, C.,Ramirez Flores, R. O.,Li, Z.,Hannani, M. T.,Tanevski, J.,Halder, M.,Cheng, M.,Ziegler, S.,Zhang, X.,Priester, F.,Kaesler, N.,Xu, Y.,Hoogenboezem, R.,Bindels, E.,Schneider-Kramann, R.,Milting, H.,Gesteira Costa Filho, I.,Saez Rodriguez, J.,Kramann, R. Spatial multi-omic map of human myocardial infarction. bioRxiv 2020, 2020.2012.2008.411686.

Kaesler, N.,Goettsch, C.,Weis, D.,Schurgers, L.,Hellmann, B.,Floege, J.,Kramann, R. Magnesium but not nicotinamide prevents vascular calcification in experimental uraemia. Nephrol Dial Transplant 2020, 35, 65-73.

Kaesler, N.,Babler, A.,Floege, J.,Kramann, R. Cardiac Remodeling in Chronic Kidney Disease. Toxins (Basel) 2020, 12.

Herrmann, M.,Babler, A.,Moshkova, I.,Gremse, F.,Kiessling, F.,Kusebauch, U.,Nelea, V.,Kramann, R.,Moritz, R. L.,McKee, M. D.,Jahnen-Dechent, W. Lumenal calcification and microvasculopathy in fetuin-A-deficient mice lead to multiple organ morbidity. PLoS One 2020, 15, e0228503.

Gleitz, H.,Dugourd, A. J. F.,Leimkühler, N. B.,Snoeren, I. A. M.,Fuchs, S. N. R.,Menzel, S.,Ziegler, S.,Kroeger, N.,Triviai, I.,Büsche, G.,Kreipe, H.,Banjanin, B.,Pritchard, J.,Hoogenboezem, R.,Bindels, E.,Schumacher, N.,Rose-John, S.,Elf, S.,Saez-Rodriguez, J.,Kramann, R.,Schneider, R. K. Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN. Blood 2020.

Broeker, K. A. E.,Fuchs, M. A. A.,Schrankl, J.,Kurt, B.,Nolan, K. A.,Wenger, R. H.,Kramann, R.,Wagner, C.,Kurtz, A. Different subpopulations of kidney interstitial cells produce erythropoietin and factors supporting tissue oxygenation in response to hypoxia in vivo. Kidney Int 2020.

Brandt, S.,Ballhause, T. M.,Bernhardt, A.,Becker, A.,Salaru, D.,Le-Deffge, H. M.,Fehr, A.,Fu, Y.,Philipsen, L.,Djudjaj, S.,Müller, A. J.,Kramann, R.,Ibrahim, M.,Geffers, R.,Siebel, C.,Isermann, B.,Heidel, F. H.,Lindquist, J. A.,Mertens, P. R. Fibrosis and Immune Cell Infiltration Are Separate Events Regulated by Cell-Specific Receptor Notch3 Expression. J Am Soc Nephrol 2020.

Akbulut, A. C.,Pavlic, A.,Petsophonsakul, P.,Halder, M.,Maresz, K.,Kramann, R.,Schurgers, L. Vitamin K2 Needs an RDI Separate from Vitamin K1. Nutrients 2020, 12.

Leimkühler, N.B.,Gleitz, H.F.E.,Ronghui, L.,Snoeren, I.A.M.,Fuchs, S.N.R.,Nagai, J.S.,Banjanin, B.,Lam, K.H.,Vogl, T.,Kuppe, C.,Stalmann, U.S.A.,Büsche, G.,Kreipe, H.,Gütgemann, I.,Krebs, P.,Banz, Y.,Boor, P.,Tai, E.W.,Brümmendorf, T.H.,Koschmieder, S.,Crysandt, M.,Bindels, E.,Kramann, R.,Costa, I.G.,Schneider, R.K. Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis. Cell Stem Cell 2020, S1934-5909, 30542-30547

Meijer, E.M.,van Dijk, C.G.M.,Kramann, R.,Verhaar, M.C.,Cheng, C. Implementation of pericytes in vascular regeneration strategies. Tissue Eng Part B Rev. 2020

van Kuijk, K.,Kuppe, C.,Betsholtz, C.,Vanlandewijck, M.,Kramann, R.,Sluimer, J. C. Heterogeneity and plasticity in healthy and atherosclerotic vasculature explored by single-cell sequencing. Cardiovasc Res 2019, 115, 1705-1715.

Sun, Q.,Baues, M.,Klinkhammer, B. M.,Ehling, J.,Djudjaj, S.,Drude, N. I.,Daniel, C.,Amann, K.,Kramann, R.,Kim, H.,Saez-Rodriguez, J.,Weiskirchen, R.,Onthank, D. C.,Botnar, R. M.,Kiessling, F.,Floege, J.,Lammers, T.,Boor, P. Elastin imaging enables noninvasive staging and treatment monitoring of kidney fibrosis. Sci Transl Med 2019, 11.

Saritas, T.,Puelles, V. G.,Su, X. T.,Ellison, D. H.,Kramann, R. Optical Clearing and Imaging of Immunolabeled Kidney Tissue. J Vis Exp 2019.

Saritas, T.,Cuevas, C. A.,Ferdaus, M. Z.,Kuppe, C.,Kramann, R.,Moeller, M. J.,Floege, J.,Singer, J. D.,McCormick, J. A. Disruption of CUL3-mediated ubiquitination causes proximal tubule injury and kidney fibrosis. Sci Rep 2019, 9, 4596.

Saez-Rodriguez, J.,Rinschen, M. M.,Floege, J.,Kramann, R. The authors reply. Kidney Int 2019, 96, 1422-1423.

Saez-Rodriguez, J.,Rinschen, M. M.,Floege, J.,Kramann, R. Big science and big data in nephrology. Kidney Int 2019, 95, 1326-1337.

Rohwer, N.,Jumpertz, S.,Erdem, M.,Egners, A.,Warzecha, K. T.,Fragoulis, A.,Kühl, A. A.,Kramann, R.,Neuss, S.,Rudolph, I.,Endermann, T.,Zasada, C.,Apostolova, I.,Gerling, M.,Kempa, S.,Hughes, R.,Lewis, C. E.,Brenner, W.,Malinowski, M. B.,Stockmann, M.,Schomburg, L.,Faller, W.,Sansom, O. J.,Tacke, F.,Morkel, M.,Cramer, T. Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis. Oncogene 2019, 38, 5670-5685.

Ribezzo, F.,Snoeren, I. A. M.,Ziegler, S.,Stoelben, J.,Olofsen, P. A.,Henic, A.,Ferreira, M. V.,Chen, S.,Stalmann, U. S. A.,Buesche, G.,Hoogenboezem, R. M.,Kramann, R.,Platzbecker, U.,Raaijmakers, M.,Ebert, B. L.,Schneider, R. K. Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome. Leukemia 2019, 33, 1759-1772.

Puelles, V. G.,van der Wolde, J. W.,Wanner, N.,Scheppach, M. W.,Cullen-McEwen, L. A.,Bork, T.,Lindenmeyer, M. T.,Gernhold, L.,Wong, M. N.,Braun, F.,Cohen, C. D.,Kett, M. M.,Kuppe, C.,Kramann, R.,Saritas, T.,van Roeyen, C. R.,Moeller, M. J.,Tribolet, L.,Rebello, R.,Sun, Y. B.,Li, J.,Müller-Newen, G.,Hughson, M. D.,Hoy, W. E.,Person, F.,Wiech, T.,Ricardo, S. D.,Kerr, P. G.,Denton, K. M.,Furic, L.,Huber, T. B.,Nikolic-Paterson, D. J.,Bertram, J. F. mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans. JCI Insight 2019, 4.

Puelles, V. G.,Fleck, D.,Ortz, L.,Papadouri, S.,Strieder, T.,Böhner, A. M. C.,van der Wolde, J. W.,Vogt, M.,Saritas, T.,Kuppe, C.,Fuss, A.,Menzel, S.,Klinkhammer, B. M.,Müller-Newen, G.,Heymann, F.,Decker, L.,Braun, F.,Kretz, O.,Huber, T. B.,Susaki, E. A.,Ueda, H. R.,Boor, P.,Floege, J.,Kramann, R.,Kurts, C.,Bertram, J. F.,Spehr, M.,Nikolic-Paterson, D. J.,Moeller, M. J. Novel 3D analysis using optical tissue clearing documents the evolution of murine rapidly progressive glomerulonephritis. Kidney Int 2019, 96, 505-516.

Jahn, L.,Kramann, R.,Marx, N.,Floege, J.,Becker, M.,Schlieper, G. Speckle Tracking Echocardiography and All-Cause and Cardiovascular Mortality Risk in Chronic Kidney Disease Patients. Kidney Blood Press Res 2019, 44, 690-703.

Halder, M.,Petsophonsakul, P.,Akbulut, A. C.,Pavlic, A.,Bohan, F.,Anderson, E.,Maresz, K.,Kramann, R.,Schurgers, L. Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease. Int J Mol Sci 2019, 20.

Brandt, M. M.,van Dijk, C. G. M.,Maringanti, R.,Chrifi, I.,Kramann, R.,Verhaar, M. C.,Duncker, D. J.,Mokry, M.,Cheng, C. Transcriptome analysis reveals microvascular endothelial cell-dependent pericyte differentiation. Sci Rep 2019, 9, 15586.

Brandenburg, V. M.,Schuh, A.,Kramann, R. Valvular Calcification in Chronic Kidney Disease. Adv Chronic Kidney Dis 2019, 26, 464-471.

Schurgers, L. J.,Akbulut, A. C.,Kaczor, D. M.,Halder, M.,Koenen, R. R.,Kramann, R. Initiation and Propagation of Vascular Calcification Is Regulated by a Concert of Platelet- and Smooth Muscle Cell-Derived Extracellular Vesicles. Front Cardiovasc Med 2018, 5, 36.

Schneider, R. K.,Mullally, A.,Dugourd, A.,Peisker, F.,Hoogenboezem, R.,Van Strien, P. M. H.,Bindels, E. M.,Heckl, D.,Büsche, G.,Fleck, D.,Müller-Newen, G.,Wongboonsin, J.,Ventura Ferreira, M.,Puelles, V. G.,Saez-Rodriguez, J.,Ebert, B. L.,Humphreys, B. D.,Kramann, R. Gli1(+) Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target. Cell Stem Cell 2018, 23, 308-309.

Noels, H.,Boor, P.,Goettsch, C.,Hohl, M.,Jahnen-Dechent, W.,Jankowski, V.,Kindermann, I.,Kramann, R.,Lehrke, M.,Linz, D.,Maack, C.,Niemeyer, B.,Roma, L. P.,Schuett, K.,Speer, T.,Wagenpfeil, S.,Werner, C.,Zewinger, S.,Böhm, M.,Marx, N.,Floege, J.,Fliser, D.,Jankowski, J. The new SFB/TRR219 Research Centre. Eur Heart J 2018, 39, 975-977.

Kramann, R.,Schneider, R. K. The identification of fibrosis-driving myofibroblast precursors reveals new therapeutic avenues in myelofibrosis. Blood 2018, 131, 2111-2119.

Kramann, R.,Machado, F.,Wu, H.,Kusaba, T.,Hoeft, K.,Schneider, R. K.,Humphreys, B. D. Parabiosis and single-cell RNA sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis. JCI Insight 2018, 3.

Kaesler, N.,Verhulst, A.,De Maré, A.,Deck, A.,Behets, G. J.,Hyusein, A.,Evenepoel, P.,Floege, J.,Marx, N.,Babler, A.,Kramer, I.,Kneissel, M.,Kramann, R.,Weis, D.,D'Haese, P. C.,Brandenburg, V. M. Sclerostin deficiency modifies the development of CKD-MBD in mice. Bone 2018, 107, 115-123.

Höhne, M.,Frese, C. K.,Grahammer, F.,Dafinger, C.,Ciarimboli, G.,Butt, L.,Binz, J.,Hackl, M. J.,Rahmatollahi, M.,Kann, M.,Schneider, S.,Altintas, M. M.,Schermer, B.,Reinheckel, T.,Göbel, H.,Reiser, J.,Huber, T. B.,Kramann, R.,Seeger-Nukpezah, T.,Liebau, M. C.,Beck, B. B.,Benzing, T.,Beyer, A.,Rinschen, M. M. Single-nephron proteomes connect morphology and function in proteinuric kidney disease. Kidney Int 2018, 93, 1308-1319.

Gleitz, H. F.,Kramann, R.,Schneider, R. K. Understanding deregulated cellular and molecular dynamics in the haematopoietic stem cell niche to develop novel therapeutics for bone marrow fibrosis. J Pathol 2018, 245, 138-146.

Schneider, R. K.,Mullally, A.,Dugourd, A.,Peisker, F.,Hoogenboezem, R.,Van Strien, P. M. H.,Bindels, E. M.,Heckl, D.,Büsche, G.,Fleck, D.,Müller-Newen, G.,Wongboonsin, J.,Ventura Ferreira, M.,Puelles, V. G.,Saez-Rodriguez, J.,Ebert, B. L.,Humphreys, B. D.,Kramann, R. Gli1(+) Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target. Cell Stem Cell 2017, 20, 785-800.e788.

Mukherjee, E.,Maringer, K.,Papke, E.,Bushnell, D.,Schaefer, C.,Kramann, R.,Ho, J.,Humphreys, B. D.,Bates, C.,Sims-Lucas, S. Endothelial marker-expressing stromal cells are critical for kidney formation. Am J Physiol Renal Physiol 2017, 313, F611-f620.

Kramann, R.,Wongboonsin, J.,Chang-Panesso, M.,Machado, F. G.,Humphreys, B. D. Gli1(+) Pericyte Loss Induces Capillary Rarefaction and Proximal Tubular Injury. J Am Soc Nephrol 2017, 28, 776-784.

El Agha, E.,Kramann, R.,Schneider, R. K.,Li, X.,Seeger, W.,Humphreys, B. D.,Bellusci, S. Mesenchymal Stem Cells in Fibrotic Disease. Cell Stem Cell 2017, 21, 166-177.

Brandenburg, V. M.,Reinartz, S.,Kaesler, N.,Krüger, T.,Dirrichs, T.,Kramann, R.,Peeters, F.,Floege, J.,Keszei, A.,Marx, N.,Schurgers, L. J.,Koos, R. Slower Progress of Aortic Valve Calcification With Vitamin K Supplementation: Results From a Prospective Interventional Proof-of-Concept Study. Circulation 2017, 135, 2081-2083.

Brandenburg, V. M.,Kramann, R.,Rothe, H.,Kaesler, N.,Korbiel, J.,Specht, P.,Schmitz, S.,Krüger, T.,Floege, J.,Ketteler, M. Calcific uraemic arteriolopathy (calciphylaxis): data from a large nationwide registry. Nephrol Dial Transplant 2017, 32, 126-132.

Ventura Ferreira, M. S.,Bergmann, C.,Bodensiek, I.,Peukert, K.,Abert, J.,Kramann, R.,Kachel, P.,Rath, B.,Rütten, S.,Knuchel, R.,Ebert, B. L.,Fischer, H.,Brümmendorf, T. H.,Schneider, R. K. An engineered multicomponent bone marrow niche for the recapitulation of hematopoiesis at ectopic transplantation sites. J Hematol Oncol 2016, 9, 4.

Schneider, R. K.,Schenone, M.,Ferreira, M. V.,Kramann, R.,Joyce, C. E.,Hartigan, C.,Beier, F.,Brümmendorf, T. H.,Germing, U.,Platzbecker, U.,Büsche, G.,Knüchel, R.,Chen, M. C.,Waters, C. S.,Chen, E.,Chu, L. P.,Novina, C. D.,Lindsley, R. C.,Carr, S. A.,Ebert, B. L. Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9. Nat Med 2016, 22, 288-297.

Maarouf, O. H.,Aravamudhan, A.,Rangarajan, D.,Kusaba, T.,Zhang, V.,Welborn, J.,Gauvin, D.,Hou, X.,Kramann, R.,Humphreys, B. D. Paracrine Wnt1 Drives Interstitial Fibrosis without Inflammation by Tubulointerstitial Cross-Talk. J Am Soc Nephrol 2016, 27, 781-790.

Kuppe, C.,Kramann, R. Role of mesenchymal stem cells in kidney injury and fibrosis. Curr Opin Nephrol Hypertens 2016, 25, 372-377.

Kramann, R.,Goettsch, C.,Wongboonsin, J.,Iwata, H.,Schneider, R. K.,Kuppe, C.,Kaesler, N.,Chang-Panesso, M.,Machado, F. G.,Gratwohl, S.,Madhurima, K.,Hutcheson, J. D.,Jain, S.,Aikawa, E.,Humphreys, B. D. Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease. Cell Stem Cell 2016, 19, 628-642.

Kramann, R. Hedgehog Gli signalling in kidney fibrosis. Nephrol Dial Transplant 2016, 31, 1989-1995.

Goettsch, C.,Hutcheson, J. D.,Aikawa, M.,Iwata, H.,Pham, T.,Nykjaer, A.,Kjolby, M.,Rogers, M.,Michel, T.,Shibasaki, M.,Hagita, S.,Kramann, R.,Rader, D. J.,Libby, P.,Singh, S. A.,Aikawa, E. Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. J Clin Invest 2016, 126, 1323-1336.

Brandenburg, V. M.,Kaesler, N.,Kramann, R.,Floege, J.,Marx, N. [Magnesium: a kardio-renal viewpoint]. Dtsch Med Wochenschr 2016, 141, 1537-1542.

Brandenburg, V. M.,Evenepoel, P.,Floege, J.,Goldsmith, D.,Kramann, R.,Massy, Z.,Mazzaferro, S.,Schurgers, L. J.,Sinha, S.,Torregrosa, V.,Ureña-Torres, P.,Vervloet, M.,Cozzolino, M. Lack of evidence does not justify neglect: how can we address unmet medical needs in calciphylaxis? Nephrol Dial Transplant 2016, 31, 1211-1219.

Barros, X.,Dirrichs, T.,Koos, R.,Reinartz, S.,Kaesler, N.,Kramann, R.,Gladziwa, U.,Ketteler, M.,Floege, J.,Marx, N.,Torregrosa, J. V.,Keszei, A.,Brandenburg, V. M. Epicardial adipose tissue in long-term hemodialysis patients: its association with vascular calcification and long-term development. J Nephrol 2016, 29, 241-250.

Kramann, R.,Schneider, R. K.,DiRocco, D. P.,Machado, F.,Fleig, S.,Bondzie, P. A.,Henderson, J. M.,Ebert, B. L.,Humphreys, B. D. Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis. Cell Stem Cell 2015, 16, 51-66.

Kramann, R.,Kusaba, T.,Humphreys, B. D. Who regenerates the kidney tubule? Nephrol Dial Transplant 2015, 30, 903-910.

Kramann, R.,Fleig, S. V.,Schneider, R. K.,Fabian, S. L.,DiRocco, D. P.,Maarouf, O.,Wongboonsin, J.,Ikeda, Y.,Heckl, D.,Chang, S. L.,Rennke, H. G.,Waikar, S. S.,Humphreys, B. D. Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis. J Clin Invest 2015, 125, 2935-2951.

Schneider, R. K.,Ademà, V.,Heckl, D.,Järås, M.,Mallo, M.,Lord, A. M.,Chu, L. P.,McConkey, M. E.,Kramann, R.,Mullally, A.,Bejar, R.,Solé, F.,Ebert, B. L. Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS. Cancer Cell 2014, 26, 509-520.

Kusaba, T.,Lalli, M.,Kramann, R.,Kobayashi, A.,Humphreys, B. D. Differentiated kidney epithelial cells repair injured proximal tubule. Proc Natl Acad Sci U S A 2014, 111, 1527-1532.

Kramann, R.,Tanaka, M.,Humphreys, B. D. Fluorescence microangiography for quantitative assessment of peritubular capillary changes after AKI in mice. J Am Soc Nephrol 2014, 25, 1924-1931.

Kramann, R.,Humphreys, B. D. Kidney pericytes: roles in regeneration and fibrosis. Semin Nephrol 2014, 34, 374-383.

Kramann, R.,Erpenbeck, J.,Schneider, R. K.,Röhl, A. B.,Hein, M.,Brandenburg, V. M.,van Diepen, M.,Dekker, F.,Marx, N.,Floege, J.,Becker, M.,Schlieper, G. Speckle tracking echocardiography detects uremic cardiomyopathy early and predicts cardiovascular mortality in ESRD. J Am Soc Nephrol 2014, 25, 2351-2365.

Klinkhammer, B. M.,Kramann, R.,Mallau, M.,Makowska, A.,van Roeyen, C. R.,Rong, S.,Buecher, E. B.,Boor, P.,Kovacova, K.,Zok, S.,Denecke, B.,Stuettgen, E.,Otten, S.,Floege, J.,Kunter, U. Mesenchymal stem cells from rats with chronic kidney disease exhibit premature senescence and loss of regenerative potential. PLoS One 2014, 9, e92115.

Kramann, R.,Schneider, R. K. Parathyroid hormone-related protein and regulation of cell survival in the kidney. Kidney Int 2013, 83, 777-779.

Kramann, R.,Kunter, U.,Brandenburg, V. M.,Leisten, I.,Ehling, J.,Klinkhammer, B. M.,Knüchel, R.,Floege, J.,Schneider, R. K. Osteogenesis of heterotopically transplanted mesenchymal stromal cells in rat models of chronic kidney disease. J Bone Miner Res 2013, 28, 2523-2534.

Kramann, R.,Dirocco, D. P.,Maarouf, O. H.,Humphreys, B. D. Matrix Producing Cells in Chronic Kidney Disease: Origin, Regulation, and Activation. Curr Pathobiol Rep 2013, 1.

Kramann, R.,DiRocco, D. P.,Humphreys, B. D. Understanding the origin, activation and regulation of matrix-producing myofibroblasts for treatment of fibrotic disease. J Pathol 2013, 231, 273-289.

Kramann, R.,Brandenburg, V. M.,Schurgers, L. J.,Ketteler, M.,Westphal, S.,Leisten, I.,Bovi, M.,Jahnen-Dechent, W.,Knüchel, R.,Floege, J.,Schneider, R. K. Novel insights into osteogenesis and matrix remodelling associated with calcific uraemic arteriolopathy. Nephrol Dial Transplant 2013, 28, 856-868.

Koos, R.,Brandenburg, V.,Mahnken, A. H.,Schneider, R.,Dohmen, G.,Autschbach, R.,Marx, N.,Kramann, R. Sclerostin as a potential novel biomarker for aortic valve calcification: an in-vivo and ex-vivo study. J Heart Valve Dis 2013, 22, 317-325.

Brandenburg, V. M.,Kramann, R.,Koos, R.,Krüger, T.,Schurgers, L.,Mühlenbruch, G.,Hübner, S.,Gladziwa, U.,Drechsler, C.,Ketteler, M. Relationship between sclerostin and cardiovascular calcification in hemodialysis patients: a cross-sectional study. BMC Nephrol 2013, 14, 219.

Yagmur, E.,Koch, A.,Haumann, M.,Kramann, R.,Trautwein, C.,Tacke, F. Hyaluronan serum concentrations are elevated in critically ill patients and associated with disease severity. Clin Biochem 2012, 45, 82-87.

van de Kamp, J.,Kramann, R.,Anraths, J.,Schöler, H. R.,Ko, K.,Knüchel, R.,Zenke, M.,Neuss, S.,Schneider, R. K. Epithelial morphogenesis of germline-derived pluripotent stem cells on organotypic skin equivalents in vitro. Differentiation 2012, 83, 138-147.

Leisten, I.,Kramann, R.,Ventura Ferreira, M. S.,Bovi, M.,Neuss, S.,Ziegler, P.,Wagner, W.,Knüchel, R.,Schneider, R. K. 3D co-culture of hematopoietic stem and progenitor cells and mesenchymal stem cells in collagen scaffolds as a model of the hematopoietic niche. Biomaterials 2012, 33, 1736-1747.

Kramann, R.,Frank, D.,Brandenburg, V. M.,Heussen, N.,Takahama, J.,Krüger, T.,Riehl, J.,Floege, J. Prognostic impact of renal arterial resistance index upon renal allograft survival: the time point matters. Nephrol Dial Transplant 2012, 27, 3958-3963.

Kramann, R.,Floege, J.,Ketteler, M.,Marx, N.,Brandenburg, V. M. Medical options to fight mortality in end-stage renal disease: a review of the literature. Nephrol Dial Transplant 2012, 27, 4298-4307.

Kramann, R.,Couson, S. K.,Neuss, S.,Floege, J.,Knüchel, R.,Schneider, R. K. Uraemia disrupts the vascular niche in a 3D co-culture system of human mesenchymal stem cells and endothelial cells. Nephrol Dial Transplant 2012, 27, 2693-2702.

Brandenburg, V. M.,Kramann, R.,Specht, P.,Ketteler, M. Calciphylaxis in CKD and beyond. Nephrol Dial Transplant 2012, 27, 1314-1318.

Kramann, R.,Moeller, M. J. The next level of complexity: post-transcriptional regulation by microRNAs. Kidney Int 2011, 80, 692-693.

Kramann, R.,Couson, S. K.,Neuss, S.,Kunter, U.,Bovi, M.,Bornemann, J.,Knüchel, R.,Jahnen-Dechent, W.,Floege, J.,Schneider, R. K. Exposure to uremic serum induces a procalcific phenotype in human mesenchymal stem cells. Arterioscler Thromb Vasc Biol 2011, 31, e45-54.

Schneider, R. K.,Püllen, A.,Kramann, R.,Bornemann, J.,Knüchel, R.,Neuss, S.,Perez-Bouza, A. Long-term survival and characterisation of human umbilical cord-derived mesenchymal stem cells on dermal equivalents. Differentiation 2010, 79, 182-193.

Schneider, R. K.,Puellen, A.,Kramann, R.,Raupach, K.,Bornemann, J.,Knuechel, R.,Pérez-Bouza, A.,Neuss, S. The osteogenic differentiation of adult bone marrow and perinatal umbilical mesenchymal stem cells and matrix remodelling in three-dimensional collagen scaffolds. Biomaterials 2010, 31, 467-480.

Schneider, R. K.,Anraths, J.,Kramann, R.,Bornemann, J.,Bovi, M.,Knüchel, R.,Neuss, S. The role of biomaterials in the direction of mesenchymal stem cell properties and extracellular matrix remodelling in dermal tissue engineering. Biomaterials 2010, 31, 7948-7959.

Becker, M.,Lenzen, A.,Ocklenburg, C.,Stempel, K.,Kühl, H.,Neizel, M.,Katoh, M.,Kramann, R.,Wildberger, J.,Kelm, M.,Hoffmann, R. Myocardial deformation imaging based on ultrasonic pixel tracking to identify reversible myocardial dysfunction. J Am Coll Cardiol 2008, 51, 1473-1481.

Becker, M.,Kramann, R.,Franke, A.,Breithardt, O. A.,Heussen, N.,Knackstedt, C.,Stellbrink, C.,Schauerte, P.,Kelm, M.,Hoffmann, R. Impact of left ventricular lead position in cardiac resynchronization therapy on left ventricular remodelling. A circumferential strain analysis based on 2D echocardiography. Eur Heart J 2007, 28, 1211-1220.

Becker, M.,Kramann, R.,Dohmen, G.,Lückhoff, A.,Autschbach, R.,Kelm, M.,Hoffmann, R. Impact of left ventricular loading conditions on myocardial deformation parameters: analysis of early and late changes of myocardial deformation parameters after aortic valve replacement. J Am Soc Echocardiogr 2007, 20, 681-689.

Becker, M.,Franke, A.,Breithardt, O. A.,Ocklenburg, C.,Kaminski, T.,Kramann, R.,Knackstedt, C.,Stellbrink, C.,Hanrath, P.,Schauerte, P.,Hoffmann, R. Impact of left ventricular lead position on the efficacy of cardiac resynchronisation therapy: a two-dimensional strain echocardiography study. Heart 2007, 93, 1197-1203.

Becker, M.,Hoffmann, R.,Kühl, H. P.,Grawe, H.,Katoh, M.,Kramann, R.,Bücker, A.,Hanrath, P.,Heussen, N. Analysis of myocardial deformation based on ultrasonic pixel tracking to determine transmurality in chronic myocardial infarction. Eur Heart J 2006, 27, 2560-2566.

Becker, M.,Bilke, E.,Kühl, H.,Katoh, M.,Kramann, R.,Franke, A.,Bücker, A.,Hanrath, P.,Hoffmann, R. Analysis of myocardial deformation based on pixel tracking in two dimensional echocardiographic images enables quantitative assessment of regional left ventricular function. Heart 2006, 92, 1102-1108.