Publications

ITIH5 as a multifaceted player in pancreatic cancer suppression, impairing tyrosine kinase signaling, cell adhesion and migration.
Jennifer Kosinski, Antonio Sechi, Johanna Hain, Sophia Villwock, Stefanie Anh Ha, Maximilian Hauschulz, Michael Rose, Florian Steib, Nadina Ortiz-Brüchle, Lara Heij, Sanne L Maas, Emiel P C van der Vorst, Thomas Knoesel, Annelore Altendorf-Hofmann, Ronald Simon, Guido Sauter, Jan Bednarsch, Danny Jonigk, Edgar Dahl.
Mol Oncol. 2024 Feb 20. doi: 10.1002/1878-0261.13609. 

Genetic deletion of ITIH5 leads to increased development of adipose tissue in mice.
Thomas M Sessler, Justus P Beier, Sophia Villwock, Danny Jonigk, Edgar Dahl, Tim Ruhl.
Biol Res . 2024 Aug 29;57(1):58. doi: 10.1186/s40659-024-00530-0. 

ITIH5 inhibits proliferation, adipogenic differentiation, and secretion of inflammatory cytokines of human adipose stem cells-A new key in treating obesity?
Tim Ruhl, Thomas M Sessler, Jana M Keimes, Justus P Beier, Sophia Villwock, Michael Rose, Edgar Dahl.
FASEB J. 2024 Jan;38(1):e23352. doi: 10.1096/fj.202301366R.

HER4 Affects Sensitivity to Tamoxifen and Abemaciclib in Luminal Breast Cancer Cells and Restricts Tumor Growth in MCF-7-Based Humanized Tumor Mice.
Albert V, Bruss C, Tümen D, Piendl G, Weber F, Dahl E, Seitz S, Ortmann O, Wege AK, Brockhoff G. Int J Mol Sci. 2024 Jul 8;25(13):7475. doi: 10.3390/ijms25137475. PMID: 39000582; PMCID: PMC11242770.

Preoperative predictors for non-resectability in perihilar cholangiocarcinoma.
Carlos Constantin Otto, Anna Manta, Lara Rosaline Heij, Daniel Heise, Maxime Dewulf, Sven Arke Lang, Tom Florian Ulmer, Edgar Dahl, Philipp Bruners, Ulf Peter Neumann, Jan Bednarsch.
World J Surg Oncol. 2024 Feb 7;22(1):48. doi: 10.1186/s12957-024-03329-1.

Platelets from patients with chronic inflammation have a phenotype of chronic IL-1β release
Martin Berger, Hendrik Maqua, Katharina Lysaja, Sebastian Frederik Mause, Mathew S Hindle, Khalid Naseem, Edgar Dahl, Thimoteus Speer, Nikolaus Marx, Katharina Schütt.
Res Pract Thromb Haemost. 2023 Nov 14;8(1):102261. doi: 10.1016/j.rpth.2023.102261. eCollection 2024 Jan.

SARS-CoV-2 related

A multicenter study of asymmetric and symmetric dimethylarginine as predictors of mortality risk in hospitalized COVID-19 patients.
Hannemann J, Zink A, Mileva Y, Balfanz P, Dahl E, Volland S, Illig T, Schwedhelm E, Kurth F, Stege A, Aepfelbacher M, Hoffmann A, Böger R. Sci Rep. 2024 Jul 8;14(1):15739. doi: 10.1038/s41598-024-66288-3. PMID: 38977837; PMCID: PMC11231343

Definition of the Post-COVID syndrome using a symptom-based Post-COVID score in a prospective, multi-center, cross-sectoral cohort of the German National Pandemic Cohort Network (NAPKON).
Appel KS, Nürnberger C, Bahmer T, Förster C, Polidori MC, Kohls M, Kraus T, Hettich-Damm N, Petersen J, Blaschke S, Bröhl I, Butzmann J, Dashti H, Deckert J, Dreher M, Fiedler K, Finke C, Geisler R, Hanses F, Hopff SM, Jensen BO, Konik M, Lehnert K, de Miranda SMN, Mitrov L, Miljukov O, Reese JP, Rohde G, Scherer M, Tausche K, Tebbe JJ, Vehreschild JJ, Voit F, Wagner P, Weigl M, Lemhöfer C; NAPKON Study Group. Infection. 2024 Apr 8. doi: 10.1007/s15010-024-02226-9. Epub ahead of print. PMID: 38587752.

Identification and Validation of Potentially Clinically Relevant CpG Regions within the Class 2 Tumor Suppressor Gene SFRP1 in Pancreatic Cancer
Maximilian Hauschulz, Sophia Villwock, Jennifer Kosinski, Florian Steib, Lara Rosaline Heij, Jan Bednarsch, Ruth Knüchel-Clarke, Edgar Dahl.
Cancers (Basel). 2023 Jan 22;15(3):683.doi: 10.3390/cancers15030683.

Genetic polymorphisms in interleukin-1β (rs1143634) and interleukin-8 (rs4073) are associated with survival after resection of intrahepatic cholangiocarcinoma.
Isabella Lurje, Nadine Therese Gaisa, Edgar Dahl, Ruth Knüchel, Pavel Strnad, Christian Trautwein, Frank Tacke, Ulf Peter Neumann, Zoltan Czigany, Georg Lurje.
Sci Rep. 2023 Jul 28;13(1):12283. doi: 10.1038/s41598-023-39487-7.

Fluorescence in situ hybridization test for detection of endometrial carcinoma cells by non-invasive vaginal swab.
Jörg Weimer, Martje Hüttmann, Asiyan Nusilati, Svenja Andreas, Jona Röseler, Nils Tribian, Christoph Rogmans, Matthias Bernhard Stope, Edgar Dahl, Alexander Mustea, Elmar Stickeler, Nina Hedemann, Inken Flörkemeier, Katharina Tiemann, Svetlana Magadeeva, Astrid Dempfle, Norbert Arnold, Nicolai Maass, Dirk Bauerschlag.
J Cell Mol Med. 2023 Jan 10. doi: 10.1111/jcmm.17658. Online ahead of print.

Impact of Altered Body Composition on Clinical and Oncological Outcomes in Intrahepatic Cholangiocarcinoma
Guanwu Wang, Carlos C Otto, Lara R Heij, Tarick M Al-Masri, Edgar Dahl, Daniel Heise, Steven W M Olde Damink, Tom Luedde, Sven A Lang, Tom F Ulmer, Ulf P Neumann, Jan Bednarsch.
J Clin Med. 2023 Dec 18;12(24):7747. doi: 10.3390/jcm12247747.

SARS-CoV-2 related

A Potential Association between Ribonuclease 1 Dynamics in the Blood and the Outcome in COVID-19 Patients.
Elisabeth Zechendorf, Christian Beckers, Nadine Frank, Sandra Kraemer, Carolina Neu, Thomas Breuer, Michael Dreher, Edgar Dahl, Gernot Marx, Lukas Martin, Tim-Philipp Simon.
Int J Mol Sci. 2023 Aug 4;24(15):12428. doi: 10.3390/ijms241512428.

The Role of Single-Nucleotide Polymorphisms in Cholangiocarcinoma: A Systematic Review
Wang G, Heij LR, Liu D, Dahl E, Lang SA, Ulmer TF, Luedde T, Neumann UP, Bednarsch J.
Cancers 2022, 14(23), 5969; doi: 10.3390/cancers14235969.

The role of tumor-infiltrating lymphocytes in cholangiocarcinoma
Liu D, Heij LR, Czigany Z, Dahl E, Lang SA, Ulmer TF, Luedde T, Neumann UP, Bednarsch J. J Exp Clin Cancer Res. 2022 Apr 7;41(1):127. doi: 10.1186/s13046-022-02340-2. PMID: 35392957; PMCID: PMC8988317.

The prognostic value of neutrophil-to-lymphocyte ratio in cholangiocarcinoma: a systematic review and meta-analysis
Liu D, Heij LR, Czigany Z, Dahl E, Dulk MD, Lang SA, Ulmer TF, Neumann UP, Bednarsch J. Sci Rep. 2022 Jul 25;12(1):12691. doi: 10.1038/s41598-022-16727-w. PMID: 35879385; PMCID: PMC9314341.

ITIH5-Derived Polypeptides Covering the VIT Domain Suppress the Growth of Human Cancer Cells In Vitro.
Michael Rose, Sebastian Huth, Marc Wiesehöfer, Josef Ehling, Corinna Henkel, Julia Steitz, Twan Lammers, Jennifer Kistermann, Oliver Klaas, Maximilian Koch, Sandra Rushrush, Ruth Knüchel, Edgar Dahl.
Cancers 2022, 14(3), 488; doi: 10.3390/cancers14030488.

Genetic Variant of CXCR1 (rs2234671) Associates with Clinical Outcome in Perihilar Cholangiocarcinoma
Isabella Lurje, Zoltan Czigany, Jan Bednarsch, Nadine Therese Gaisa, Edgar Dahl, Ruth Knüchel, Hannah Miller, Tom Florian Ulmer, Pavel Strnad, Christian Trautwein, Frank Tacke, Ulf Peter Neumann, Georg Lurje.
Liver Cancer 2022, 11(2):162-173. doi: 10.1159/000521613. eCollection 2022 Apr.

White Paper: Mimetics of Class 2 Tumor Suppressor Proteins as Novel Drug Candidates for Personalized Cancer Therapy
Edgar Dahl, Sophia Villwock, Peter Habenberger, Axel Choidas, Michael Rose, Bert M. Klebl
Cancers 2022, 14(18), 4386; https://doi.org/10.3390/cancers14184386

SARS-CoV-2 related

Statistical biases due to anonymization evaluated in an open clinical dataset from COVID-19 patients.
Carolin E M Koll, Sina M Hopff, Thierry Meurers, Chin Huang Lee, Mirjam Kohls, Christoph Stellbrink, Charlotte Thibeault, Lennart Reinke, Sarah Steinbrecher, Stefan Schreiber, Lazar Mitrov, Sandra Frank, Olga Miljukov, Johanna Erber, Johannes C Hellmuth, Jens-Peter Reese, Fridolin Steinbeis, Thomas Bahmer, Marina Hagen, Patrick Meybohm, Stefan Hansch, István Vadász, Lilian Krist, Steffi Jiru-Hillmann, Fabian Prasser, Jörg Janne Vehreschild; NAPKON Study Group.
Sci Data. 2022 Dec 21;9(1):776. doi: 10.1038/s41597-022-01669-9.

The Presence of Small Nerve Fibers in the Tumor Microenvironment as Predictive Biomarker of Oncological Outcome Following Partial Hepatectomy for Intrahepatic Cholangiocarcinoma.
Jan Bednarsch, Xiuxiang Tan, Zoltan Czigany, Dong Liu, Sven Arke Lang, Shivan Sivakumar, Jakob Nikolas Kather, Simone Appinger, Mika Rosin, Shiva Boroojerdi, Edgar Dahl, Nadine Therese Gaisa, Marcel den Dulk, Mariëlle Coolsen, Tom Florian Ulmer, Ulf Peter Neumann, Lara Rosaline Heij.
Cancers (Basel). 2021 Jul 21;13(15):3661. doi: 10.3390/cancers13153661.

Stakeholder engagement to ensure the sustainability of biobanks: a survey of potential users of biobank services.
Klingler C, von Jagwitz-Biegnitz M, Baber R, Becker KF, Dahl E, Eibner C, Fuchs J, Groenewold MK, Hartung ML, Hummel M, Jahns R, Kirsten R, Kopfnagel V, Maushagen R, Nussbeck SY, Schoneberg A, Winter T, Specht C.
Eur J Hum Genet. 2021 May 24. doi: 10.1038/s41431-021-00905-x. Epub ahead of print. PMID: 34031552.

Swarm Learning for decentralized and confidential clinical machine learning.
Warnat-Herresthal S, Schultze H, Shastry KL, Manamohan S, Mukherjee S, Garg V, Sarveswara R, Händler K, Pickkers P, Aziz NA, Ktena S, Tran F, Bitzer M, Ossowski S, Casadei N, Herr C, Petersheim D, Behrends U, Kern F, Fehlmann T, Schommers P, Lehmann C, Augustin M, Rybniker J, Altmüller J, Mishra N, Bernardes JP, Krämer B, Bonaguro L, Schulte-Schrepping J, De Domenico E, Siever C, Kraut M, Desai M, Monnet B, Saridaki M, Siegel CM, Drews A, Nuesch-Germano M, Theis H, Heyckendorf J, Schreiber S, Kim-Hellmuth S; COVID-19 Aachen Study (COVAS), Nattermann J, Skowasch D, Kurth I, Keller A, Bals R, Nürnberg P, Rieß O, Rosenstiel P, Netea MG, Theis F, Mukherjee S, Backes M, Aschenbrenner AC, Ulas T; Deutsche COVID-19 Omics Initiative (DeCOI), Breteler MMB, Giamarellos-Bourboulis EJ, Kox M, Becker M, Cheran S, Woodacre MS, Goh EL, Schultze JL.
Nature. 2021 May 26. doi: 10.1038/s41586-021-03583-3. Epub ahead of print. PMID: 34040261.

The ECM Modulator ITIH5 Affects Cell Adhesion, Motility and Chemotherapeutic Response of Basal/Squamous-Like (BASQ) Bladder Cancer Cells.
Michael Rose, Erik Noetzel, Jennifer Kistermann, Julian Eschenbruch, Sandra Rushrush, Lin Gan, Ruth Knüchel, Nadine T Gaisa, Edgar Dahl.
Cells. 2021 Apr 28;10(5):1038.doi: 10.3390/cells10051038.

SARS-CoV-2 related

Epigenetic Clocks Are Not Accelerated in COVID-19 Patients.
Julia Franzen, Selina Nüchtern, Vithurithra Tharmapalan, Margherita Vieri, Miloš Nikolić, Yang Han, Paul Balfanz, Nikolaus Marx, Michael Dreher, Tim H Brümmendorf, Edgar Dahl, Fabian Beier, Wolfgang Wagner.
Int J Mol Sci. 2021 Aug 27;22(17):9306. doi: 10.3390/ijms22179306.

Multisystemic Cellular Tropism of SARS-CoV-2 in Autopsies of COVID-19 Patients.
Dickson W. L. Wong, Barbara M. Klinkhammer, Sonja Djudjaj, Sophia Villwock, M. Cherelle Timm, Eva M. Buhl, Sophie Wucherpfennig, Claudio Cacchi, Till Braunschweig, Ruth Knüchel-Clarke, Danny Jonigk, Christopher Werlein, Roman D. Bülow, Edgar Dahl, Saskia von Stillfried, Peter Boor.
Cells 2021, 10(8), 1900; https://doi.org/10.3390/cells10081900.

SARS-CoV-2 RNA screening in routine pathology specimens.
Saskia von Stillfried, Sophia Villwock, Roman D Bülow, Sonja Djudjaj, Eva M Buhl, Angela Maurer, Nadina Ortiz-Brüchle, Peter Celec, Barbara M Klinkhammer, Dickson W L Wong, Claudio Cacchi, Till Braunschweig, Ruth Knüchel-Clarke, Edgar Dahl, Peter Boor.
Microb Biotechnol. 2021 May 16.doi: 10.1111/1751-7915.13828. Online ahead of print.

ACE2 polymorphism and susceptibility for SARS-CoV-2 infection and severity of COVID-19.
Möhlendick B, Schönfelder K, Breuckmann K, Elsner C, Babel N, Balfanz P, Dahl E, Dreher M, Fistera D, Herbstreit F, Hölzer B, Koch M, Kohnle M, Marx N, Risse J, Schmidt K, Skrzypczyk S, Sutharsan S, Taube C, Westhoff TH, Jöckel KH, Dittmer U, Siffert W, Kribben A.
Pharmacogenet Genomics. 2021 May 14. doi: 10.1097/FPC.0000000000000436. Epub ahead of print. PMID: 34001841.

Elevated serum SDMA and ADMA at hospital admission predict in-hospital mortality of COVID-19 patients.
Juliane Hannemann, Paul Balfanz, Edzard Schwedhelm, Bojan Hartmann,  Johanna Ule, Dirk Müller-Wieland, Edgar Dahl, Michael Dreher, Nikolaus Marx, Rainer Böger.
Sci Rep. 2021 May 10;11(1):9895.doi: 10.1038/s41598-021-89180-w.

Mutation analysis of multiple pilomatricomas in a patient with myotonic dystrophy type 1 suggests a DM1-associated hypermutation phenotype.
Rübben A, Wahl RU, Eggermann T,Dahl E, Ortiz-Brüchle N, Cacchi C.
PLoS One. 2020 Mar 10;15(3):e0230003. doi: 10.1371/journal.pone.0230003. eCollection 2020.

Deconvolution of cellular subsets in human tissue based on targeted DNA methylation analysis at individual CpG sites.
Schmidt M, Maié T, Dahl E, Costa IG, Wagner W.
BMC Biol. 2020 Nov 24;18(1):178.doi: 10.1186/s12915-020-00910-4.

Inter-α-Trypsin Inhibitor Heavy Chain 5 (ITIH5) Is a Natural Stabilizer of Hyaluronan That Modulates Biological Processes in the Skin.
Huth S, Huth L, Marquardt Y, Fietkau K, Dahl E, Esser PR, Martin SF, Heise R, Merk HF, Baron JM.
Skin Pharmacol Physiol. 2020;33(4):198-206.doi: 10.1159/000509371. Epub 2020 Aug 14.

ITIH5 and ECRG4 DNA Methylation Biomarker Test (EI-BLA) for Urine-Based Non-Invasive Detection of Bladder Cancer.
Rose M, Bringezu S, Godfrey L, Fiedler D, Gaisa NT, Koch M, Bach C, Füssel S, Herr A, Hübner D, Ellinger J, Pfister D, Knüchel R, Wirth MP, Böhme M, Dahl E.
Int J Mol Sci. 2020 Feb 7;21(3). pii: E1117. doi: 10.3390/ijms21031117.

SNiPER: a novel hypermethylation biomarker panel for liquid biopsy based early breast cancer detection.
Mijnes J, Tiedemann J, Eschenbruch J, Gasthaus J, Bringezu S, Bauerschlag D, Maass N, Arnold N, Weimer J, Anzeneder T, Fasching PA, Rübner M, Bruno B, Heindrichs U, Freres J, Schulz H, Hilgers RD, Ortiz-Brüchle N, von Serenyi S, Knüchel R, Kloten V, Dahl E.
Oncotarget. 2019 Nov 5;10(60):6494-6508. doi: 10.18632/oncotarget.27303.

[Status of the availability and use of next generation sequencing (NGS) in bladder cancer-a questionnaire within the uropathology working group].
Ortiz-Brüchle N, Muders M, Toma M, Esposito I, Hartmann A, Stöhr R, Reis H, Wild P, Köllermann J, Bremmer F, Leichsenring J, Stenzinger A, Merkelbach-Bruse S, Kirfel S, Perner S, Hartmann N, Roth W, Jung A, Kirchner T, Schwamborn K, Pfarr N, Dahl E, Knüchel R, Gaisa NT.
Urologe A. 2019 Sep 20. doi: 10.1007/s00120-019-01046-2.

[Liquid biopsy in human non-small-cell lung cancer : Blood-based analysis of ctDNA methylation].
Schulz H, Tator M, Spillner J, Dreher M, Knüchel-Clarke R, Kloten V, Dahl E.
Pathologe. 2018 Dec;39 (Suppl 2):193-198. doi: 10.1007/s00292-018-0536-5.

[Biobanking and the further development of precision medicine].
Dahl E.
Pathologe. 2018 Jun 6. doi: 10.1007/s00292-018-0449-3. Review. German.

[Biobanks : A central task in pathology].
Dahl E, Schirmacher P, Knüchel-Clarke R.
Pathologe. 2018 May 30. doi: 10.1007/s00292-018-0448-4.

Promoter methylation of DNA damage repair (DDR) genes in human tumor entities: RBBP8/CtIP is almost exclusively methylated in bladder cancer.
Mijnes J, Veeck J, Gaisa NT, Burghardt E, de Ruijter TC, Gostek S, Dahl E, Pfister D, Schmid SC, Knüchel R, Rose M.
Clin Epigenetics. 2018 Feb 6;10:15. doi:10.1186/s13148-018-0447-6.

ITIH5 induces a shift in TGF-β superfamily signaling involving Endoglin and reduces risk for breast cancer metastasis and tumor death.
Rose M, Meurer SK, Kloten V, Weiskirchen R, Denecke B, Antonopoulos W, Deckert M, Knüchel R, Dahl E.
Mol Carcinog. 2018 Feb;57(2):167-181. doi: 10.1002/mc.22742.

Expression, Intracellular Localization, and Prognostic Value of Plasminogen Activator Inhibitor 1 and PAI-1 RNA-Binding Protein 1 in Primary and Recurrent Ovarian Cancer: A Study of the Tumor Bank Ovarian Cancer Network.
Koensgen D, Stope MB, Tuerbachova I, Bruennert D, Kohlmann T, Braicu I, Sehouli J, Denkert C, Darb-Esfahani S, Stickeler E, Sofroni D,　Dahl E, Mustea A.
Gynecol Obstet Invest. 2017 Jul 22. doi: 10.1159/000479027. [Epub ahead of print]

Oncogenic features of neuromedin U in breast cancer are associated with NMUR2 expression involving crosstalk with members of the WNT signaling pathway.
Garczyk S, Klotz N, Szczepanski S, Denecke B, Antonopoulos W, von Stillfried S, Knüchel R, Rose M,　Dahl E.
Oncotarget. 2017 May 30;8(22):36246-36265. doi: 10.18632/oncotarget.16121.

ITIH5 mediates epigenetic reprogramming of breast cancer cells.
Rose M, Kloten V, Noetzel E, Gola L, Ehling J, Heide T, Meurer SK, Gaiko-Shcherbak A, Sechi AS, Huth S, Weiskirchen R, Klaas O, Antonopoulos W, Lin Q, Wagner W, Veeck J, Gremse F, Steitz J, Knüchel R,　Dahl E.
Mol Cancer. 2017 Feb 23;16(1):44. doi: 10.1186/s12943-017-0610-2.

Gene expression analysis combined with functional genomics approach identifies ITIH5 as tumor suppressor gene in cervical carcinogenesis.
Dittmann J, Ziegfeld A, Jansen L, Gajda M, Kloten V,　Dahl E, Runnebaum IB, Dürst M, Backsch C.
Mol Carcinog. 2017 Jun;56(6):1578-1589. doi: 10.1002/mc.22613. Epub 2017 Mar 6.

Liquid biopsy in colon cancer: comparison of different circulating DNA extraction systems following absolute quantification of KRAS mutations using Intplex allele-specific PCR.
Kloten V, Rüchel N, Brüchle NO, Gasthaus J, Freudenmacher N, Steib F, Mijnes J, Eschenbruch J, Binnebösel M, Knüchel R, Dahl E.
Oncotarget. 2017 8:86253-86263. doi: 10.18632/oncotarget.21134.

Epigenetic loss of putative tumor suppressor SFRP3 correlates with poor prognosis of lung adenocarcinoma patients.
Schlensog M, Magnus L, Heide T, Eschenbruch J, Steib F, Tator M, Kloten V, Rose M, Noetzel E, Gaisa NT, Knüchel R,　Dahl E.
Epigenetics. 2016 Sep 13:0. doi: 10.1080/15592294.2016.1229730. [Epub ahead of print]

Low Input Whole-Exome Sequencing to Determine the Representation of the Tumor Exome in Circulating DNA of Non-Small Cell Lung Cancer Patients.
Dietz S, Schirmer U, Mercé C, von Bubnoff N,　Dahl E, Meister M, Muley T, Thomas M, Sültmann H.
PLoS One. 2016 Aug 16;11(8):e0161012. doi: 10.1371/journal.pone.0161012. eCollection 2016.

Loss of Dickkopf 3 Promotes the Tumorigenesis of Basal Breast Cancer.
Lorsy E, Topuz AS, Geisler C, Stahl S, Garczyk S, von Stillfried S, Hoss M, Gluz O, Hartmann A, Knüchel R,　Dahl E.
PLoS One. 2016 Jul 28;11(7):e0160077. doi: 10.1371/journal.pone.0160077. eCollection 2016.

Abundant NDRG2 Expression Is Associated with Aggressiveness and Unfavorable Patients' Outcome in Basal-Like Breast Cancer.
Kloten V, Schlensog M, Eschenbruch J, Gasthaus J, Tiedemann J, Mijnes J, Heide T, Braunschweig T, Knüchel R,　Dahl E.
PLoS One. 2016 Jul 11;11(7):e0159073. doi: 10.1371/journal.pone.0159073. eCollection 2016.

The atypical cadherin Dachsous1 localizes to the base of the ciliary apparatus in airway epithelia.
Dau C, Fliegauf M, Omran H, Schlensog M,　Dahl E, van Roeyen CR, Kriz W, Moeller MJ, Braun GS.
Biochem Biophys Res Commun. 2016 May 13;473(4):1177-1184. doi: 10.1016/j.bbrc.2016.04.036. Epub 2016 Apr 10.

[Liquid biopsy analysis using cell-free DNA (cfDNA): Opportunities and limitations].
Dahl E, Kloten V.
Pathologe. 2015 Nov;36(6):572-8. doi: 10.1007/s00292-015-0078-z. Review. German.

Low expression of ITIH5 in adenocarcinoma of the lung is associated with unfavorable patients' outcome.
Dötsch MM, Kloten V, Schlensog M, Heide T, Braunschweig T, Veeck J, Petersen I, Knüchel R,　Dahl E.
Epigenetics. 2015;10(10):903-12. doi: 10.1080/15592294.2015.1078049. Epub 2015 Aug 7.

Towards sustainable data management in professional biobanking.
Leusmann P, Veeck J, Jäkel J,　Dahl E, Knüchel-Clarke R, Spreckelsen C.
Stud Health Technol Inform. 2015;212:94-102.

AGR3 in breast cancer: prognostic impact and suitable serum-based biomarker for early cancer detection.
Garczyk S, von Stillfried S, Antonopoulos W, Hartmann A, Schrauder MG, Fasching PA, Anzeneder T, Tannapfel A, Ergönenc Y, Knüchel R, Rose M,　Dahl E.
PLoS One. 2015 Apr 15;10(4):e0122106. doi: 10.1371/journal.pone.0122106. eCollection 2015.

Inter-α-trypsin inhibitor heavy chain 5 (ITIH5) is overexpressed in inflammatory skin diseases and affects epidermal morphology in constitutive knockout mice and murine 3D skin models.
Huth S, Heise R, Vetter-Kauczok CS, Skazik C, Marquardt Y, Czaja K, Knüchel R, Merk HF,　Dahl E, Baron JM.
Exp Dermatol. 2015 Sep;24(9):663-8. doi: 10.1111/exd.12704. Epub 2015 Apr 17.

OASIS/CREB3L1 is epigenetically silenced in human bladder cancer facilitating tumor cell spreading and migration in vitro.
Rose M, Schubert C, Dierichs L, Gaisa NT, Heer M, Heidenreich A, Knüchel R,　Dahl E.
Epigenetics. 2014 Dec;9(12):1626-40. doi: 10.4161/15592294.2014.988052.

[Chances and risks of blood-based molecular pathological analysis of circulating tumor cells (CTC) and cell-free DNA (cfDNA) in personalized cancer therapy: positional paper from the study group on liquid biopsy of the working group for molecular pathology in the German Society of Pathology (DGP)].
Dahl E, Jung A, Fassunke J, Hummel M, Penzel R, Dietmaier W, Laßmann S.
Pathologe. 2015 Feb;36(1):92-7. doi: 10.1007/s00292-014-2069-x. Review. German. No abstract available.

Epigenetic inactivation of ST6GAL1 in human bladder cancer.
Antony P, Rose M, Heidenreich A, Knüchel R, Gaisa NT,　Dahl E.
BMC Cancer. 2014 Dec 2;14:901. doi: 10.1186/1471-2407-14-901.

[Report of the working group on molecular pathology 2014].
Dietmaier W, Merkelbach-Bruse S,　Dahl E.
Pathologe. 2014 Nov;35 Suppl 2:298-9. doi: 10.1007/s00292-014-1981-4. German. No abstract available.

Epigenetic inactivation of the novel candidate tumor suppressor gene ITIH5 in colon cancer predicts unfavorable overall survival in the CpG island methylator phenotype.
Kloten V, Rose M, Kaspar S, von Stillfried S, Knüchel R,　Dahl E.
Epigenetics. 2014 Sep;9(9):1290-301. doi: 10.4161/epi.32089. Epub 2014 Aug 4.

BDNF is associated with SFRP1 expression in luminal and basal-like breast cancer cell lines and primary breast cancer tissues: a novel role in tumor suppression?
Huth L, Rose M, Kloubert V, Winkens W, Schlensog M, Hartmann A, Knüchel R,　Dahl E.
PLoS One. 2014 Jul 18;9(7):e102558. doi: 10.1371/journal.pone.0102558. eCollection 2014.

Loss of anterior gradient-2 expression is an independent prognostic factor in colorectal carcinomas.
Riener MO, Thiesler T, Hellerbrand C, Amann T, Cathomas G, Fritzsche FR,　Dahl E, Bahra M, Weichert W, Terracciano L, Kristiansen G.
Eur J Cancer. 2014 Jul;50(10):1722-30. doi: 10.1016/j.ejca.2014.04.012. Epub 2014 Apr 30.

Molecular Diagnostic Applications in Colorectal Cancer.
Huth L, Jäkel J,　Dahl E.
Microarrays (Basel). 2014 Jun 26;3(3):168-79. doi: 10.3390/microarrays3030168. Review.

Epigenetic inactivation of ITIH5 promotes bladder cancer progression and predicts early relapse of pT1 high-grade urothelial tumours.
Rose M, Gaisa NT, Antony P, Fiedler D, Heidenreich A, Otto W, Denzinger S, Bertz S, Hartmann A, Karl A, Knüchel R,　Dahl　E.　
Carcinogenesis. 2014 Mar;35(3):727-36.

[Personalized urooncology based on molecular uropathology: what is the future?].
Dahl E, Haller F.
Urologe A. 2013 Jul;52(7):976-81. doi: 10.1007/s00120-013-3229-y. German.

Promoter hypermethylation of the tumor-suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening.
Kloten V, Becker B, Winner K, Schrauder MG, Fasching PA, Anzeneder T, Veeck J, Hartmann A, Knüchel R,　Dahl E.
Breast Cancer Res. 2013 Jan 15;15(1):R4. doi: 10.1186/bcr3375.

A systematic comparison of quantitative high-resolution DNA methylation analysis and methylation-specific PCR.
Rainer Claus, Stefan Wilop, Thomas Hielscher, Miriam Sonnet, Edgar Dahl, Oliver Galm, Edgar Jost, Christoph Plass.
Epigenetics. 2012 Jul;7(7):772-80. doi: 10.4161/epi.20299. Epub 2012 Jul 1.

Nuclear transport receptor karyopherin-α2 promotes malignant breast cancer phenotypes in vitro.
Noetzel E, Rose M, Bornemann J, Gajewski M, Knüchel R, Dahl E.
Oncogene. 2012 Apr 19;31(16):2101-14. doi: 10.1038

Overexpression of SERBP1 (Plasminogen activator inhibitor 1 RNA binding protein) in human breast cancer is correlated with favourable prognosis.
Serce NB, Boesl A, Klaman I, von Serényi S, Noetzel E, Press MF, Dimmler A, Hartmann A, Sehouli J, Knuechel R, Beckmann MW, Fasching PA,　Dahl E.
BMC Cancer. 2012 Dec 13;12:597. doi: 10.1186/1471-2407-12-597.

REVIEWS

Targeting the Wnt pathway in cancer: the emerging role of Dickkopf-3.
Veeck J, Dahl E.
Biochim Biophys Acta. 2012 Jan;1825(1):18-28.

Aberrant DNA hypermethylation of the ITIH5 tumor suppressor gene in acute myeloid leukemia.
Oing C, Jost E, Dahl E, Wilop S, Brümmendorf TH, Galm O.
Clin Epigenetics. 2011 Aug;2(2):419-23.

Endogenous myoglobin in breast cancer is hypoxia-inducible by alternative transcription and functions to impair mitochondrial activity: a role in tumor suppression?
Kristiansen G, Hu J, Wichmann D, Stiehl DP, Rose M, Gerhardt J, Bohnert A, ten Haaf A, Moch H, Raleigh J, Varia MA, Subarsky P, Scandurra FM, Gnaiger E, Gleixner E, Bicker A, Gassmann M, Hankeln T, Dahl E, Gorr TA.
J Biol Chem. 2011 Dec 16;286(50):43417-28.

Paradox of sonic hedgehog (SHH) transcriptional regulation: Alternative transcription initiation overrides the effect of downstream promoter DNA methylation.
ten Haaf A, Franken L, Heymann C, von Serenyi S, Cornelissen C, de Hoon JP, Veeck J, Lüscher B, Knüchel R, Dahl E.
Epigenetics. 2011 Apr;6(4):465-77.

Intermediate filament dynamics and breast cancer: aberrant promoter methylation of the Synemin gene is associated with early tumor relapse.
Noetzel E, Rose M, Sevinc E, Hilgers RD, Hartmann A, Naami A, Knüchel R, Dahl E.
Oncogene. 2010 29:4814-25.　

Endogenous myoglobin in human breast cancer is a hallmark of luminal cancer phenotype.
Kristiansen G, Rose M, Geisler C, Fritzsche FR, Gerhardt J, Lüke C, Ladhoff AM, Knüchel R, Dietel M, Moch H, Varga Z, Theurillat JP, Gorr TA, Dahl E.
Br J Cancer. 2010 102:1736-45.　

RNA expression analysis on formalin-fixed paraffin-embedded tissues in TMA format by RNA in situ hybridization.
Veeck J, Dahl E.
Methods Mol Biol. 2010 664:135-50.

Characterisation of DNA methylation biomarkers for bladder cancer. Pathologe.
Antony P, Rose M, Gaisa NT, Alkaya S, Heidenreich A, Knüchel R, Dahl E.
2010 Aug 28. [Epub ahead of print] German.

Expression and localization of e-cadherin in epithelial ovarian cancer.
Koensgen D, Freitag C, Klaman I, Dahl E, Mustea A, Chekerov R, Braicu I, Lichtenegger W, Sehouli J.
Anticancer Res. 2010 7:2525-30.

Current knowledge in molecular pathology of urothelial cancer. Pathologe.
Knüchel-Clarke R, Dahl E, Gaisa NT, Schwamborn K, Lindemann-Docter K, Henkel C.
2010 Jul 29. [Epub ahead of print] German.　

Infinite mixture-of-experts model for sparse survival regression with application to breast cancer.
Raman S, Fuchs TJ, Wild PJ, Dahl E, Buhmann JM, Roth V.
BMC Bioinformatics. 2010 Oct 26;11 Suppl 8(Suppl 8):S8.doi: 10.1186/1471-2105-11-S8-S8.

Nuclear detection of Y-box protein-1 (YB-1) closely associates with progesterone receptor negativity and is a strong adverse survival factor in human breast cancer.
Dahl E, En-Nia A, Wiesmann F, Krings R, Djudjaj S, Breuer E, Fuchs T, Wild PJ, Hartmann A, Dunn SE, Mertens PR.
BMC Cancer. 2009 9:410. * (Highly accessed)

Expression of the glioma-associated oncogene homolog (GLI) 1 in human breast cancer is associated with unfavourable overall survival.
ten Haaf A, Bektas N, von Serenyi S, Losen I, Arweiler EC, Hartmann A, Knüchel R, Dahl E.
BMC Cancer. 2009 9:298. * (Highly accessed)

Dual role of macrophage migration inhibitory factor (MIF) in human breast cancer.
Verjans E, Noetzel E, Bektas N, Schütz AK, Lue H, Lennartz B, Hartmann A, Dahl E, Bernhagen J.
BMC Cancer. 2009 9:230. * (Highly accessed)

Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer.
Veeck J, Wild PJ, Fuchs T, Schüffler PJ, Hartmann A, Knüchel R, Dahl E.
BMC Cancer. 2009 9:217. * (Highly accessed)

Production and characterisation of monoclonal antibodies against RAI3 and its expression in human breast cancer.
Jörissen H, Bektas N, Dahl E, Hartmann A, ten Haaf A, Di Fiore S, Kiefer H, Thess A, Barth S, Klockenbring T.
BMC Cancer. 2009 9:200. * (Highly accessed)

Frequent loss of endothelin-3 (EDN3) expression due to epigenetic inactivation in human breast cancer.
Wiesmann F, Veeck J, Galm O, Hartmann A, Esteller M, Knüchel R, Dahl E.
Breast Cancer Res. 2009 11:R34.

Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans.
Wasmuth HE, Lammert F, Zaldivar MM, Weiskirchen R, Hellerbrand C, Scholten D, Berres ML, Zimmermann H, Streetz KL, Tacke F, Hillebrandt S, Schmitz P, Keppeler H, Berg T, Dahl E, Gassler N, Friedman SL, Trautwein C. 
Gastroenterology. 2009 137:309-19.

Decreased expression of angiogenesis antagonist EFEMP1 in sporadic breast cancer is caused by aberrant promoter methylation and points to an impact of EFEMP1 as molecular biomarker.
Sadr-Nabavi A, Ramser J, Volkmann J, Naehrig J, Wiesmann F, Betz B, Hellebrand H, Engert S, Seitz S, Kreutzfeld R, Sasaki T, Arnold N, Schmutzler R, Kiechle M, Niederacher D, Harbeck N, Dahl E, Meindl A.
Int J Cancer. 2009 124:1727-35.

The Bayesian Group-Lasso for Analyzing Contingency Tables.
Raman S, Fuchs TJ, Wild PJ, Dahl E, Roth V.
ACM International Conference Proceeding Series; Vol. 382 archive

Proceedings of the 26th Annual International Conference on Machine Learning.
Montreal, Quebec, Canada. Pages: 881-888. Year of Publication: 2009. ISBN:978-1-60558-516-1