Publications

10 Selected publications:

Koch H*, Zanella S, Elsen GE, Smith L, Doi A, Garcia AJ, Wei AD, Xun R, Kirsch S, Gomez CM, Hevner RF, Ramirez JM. 2013. Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels. J Neurosci 33:3633–3645. doi:10.1523/JNEUROSCI.6390-11.2013

Koch H, Caughie C, Elsen FP, Doi A, Garcia AJ, Zanella S, Ramirez JM. 2015b. Prostaglandin E2 differentially modulates the central control of eupnoea, sighs and gasping in mice. J Physiol 593:305–319. doi:10.1113/jphysiol.2014.279794

Koch H*, Huh S-E*, Elsen FP, Carroll MS, Hodge RD, Bedogni F, Turner MS, Hevner RF, Ramirez J-M. 2010. Prostaglandin E2-induced synaptic plasticity in neocortical networks of organotypic slice cultures. J Neurosci 30. doi:10.1523/JNEUROSCI.4665-09.2010

Koch H, Niturad CE, Theiss S, Bien CG, Elger C, Wandinger KP, Vincent A, Malter M, Körtvelyessy P, Lerche H, Dihné M. 2019b. In vitro neuronal network activity as a new functional diagnostic system to detect effects of Cerebrospinal fluid from autoimmune encephalitis patients. Sci Rep 9:1–8. doi:10.1038/s41598-019-41849-z

Koch H, Weber YG. 2019b. The glucose transporter type 1 (Glut1) syndromes. Epilepsy Behav 91:90–93. doi:10.1016/j.yebeh.2018.06.010

Schwarz N, Hedrich UBS, Schwarz H, Harshad PA, Dammeier N, Auffenberg E, Bedogni F, Honegger JB, Lerche H, Wuttke T V., Koch H*. 2017. Human Cerebrospinal fluid promotes long-term neuronal viability and network function in human neocortical organotypic brain slice cultures. Sci Rep 7:1–12. doi:10.1038/s41598-017-12527-9

Schwarz N, Uysal B, Welzer M, Bahr JC, Layer N, Löffler H, Stanaitis K, Harshad PA, Weber YG, Hedrich UBS, Honegger JB, Skodras A, Becker AJ, Wuttke T V.*, Koch H*. 2019. Long-term adult human brain slice cultures as a model system to study human CNS circuitry and disease. Elife 8. doi:10.7554/eLife.48417

Layer N, Brandes J, Lührs PJ, Wuttke T V., Koch H. 2021. The effect of lamotrigine and other antiepileptic drugs on respiratory rhythm generation in the pre-Bötzinger complex. Epilepsia 62:2790–2803. doi:10.1111/epi.17066

Kruszynski S, Stanaitis K, Brandes J, Poets CF, Koch H. 2019a. Doxapram stimulates respiratory activity through distinct activation of neurons in the nucleus hypoglossus and the pre-bötzinger complex. J Neurophysiol 121:1102–1110. doi:10.1152/jn.00304.2018

Wickham J, Corna A, Schwarz N, Uysal B, Layer N, Honegger JB, Wuttke T V., Koch H*, Zeck G*. 2020. Human Cerebrospinal Fluid Induces Neuronal Excitability Changes in Resected Human Neocortical and Hippocampal Brain Slices. Front Neurosci 14. doi:10.3389/fnins.2020.00283

Further publications

Alhaskir M, Bauer J, Linke F, Schriewer E, Weber Y, Wolking S, Röhrig R, Rothermel M, Koch H, Kutafina E. 2023a. Spectral Fusion of Heartbeat and Accelerometer Data for Estimation of Breathing Rate in Wearable Patches. Stud Health Technol Inform 302:1025–1026. doi:10.3233/SHTI230336

Bak A, Koch H, Van Loo KMJ, Schmied K, Gittel B, Weber Y, Schwarz N, Tauber SC, Wuttke T V, Delev D. 2023. Long-term human organotypic brain slice cultures: a detailed protocol to provide a comprehensive framework for single-neuron and neuronal network investigations. bioRxiv 2023.10.10.561508. doi:10.1101/2023.10.10.561508

Barth M, Bacioglu M, Schwarz N, Novotny R, Brandes J, Welzer M, Mazzitelli S, Häsler LM, Schweighauser M, Wuttke T V., Kronenberg-Versteeg D, Fog K, Ambjørn M, Alik A, Melki R, Kahle PJ, Shimshek DR, Koch H, Jucker M, Tanriöver G. 2021. Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures. Mol Neurodegener 16:54. doi:10.1186/s13024-021-00471-2

Bauer J, Devinsky O, Rothermel M, Koch H. 2023a. Autonomic dysfunction in epilepsy mouse models with implications for SUDEP research. Front Neurol. doi:10.3389/fneur.2022.1040648

Czolk R, Schwarz N, Koch H, Schötterl S, Wuttke T V., Holm PS, Huber SM, Naumann U. 2019a. Irradiation enhances the therapeutic effect of the oncolytic adenovirus XVir-N-31 in brain tumor initiating cells. Int J Mol Med 44:1484–1494. doi:10.3892/ijmm.2019.4296

Dubey M, Brouwers E, Hamilton EMC, Stiedl O, Bugiani M, Koch H, Kole MHP, Boschert U, Wykes RC, Mansvelder HD, van der Knaap MS, Min R. 2018b. Seizures and disturbed brain potassium dynamics in the leukodystrophy megalencephalic leukoencephalopathy with subcortical cysts. Ann Neurol 83:636–649. doi:10.1002/ana.25190

Fischer FP, Karge RA, Weber YG, Koch H, Wolking S, Voigt A. 2023. Drosophila melanogaster as a versatile model organism to study genetic epilepsies: An overview. Front Mol Neurosci 16:1116000. doi:10.3389/fnmol.2023.1116000

Frese H, Kauth A, Koch H, Ort J, Ingebrandt S. 2023. Fabrication and characterization of flexible microelectrode arrays for the long-term recording of mammalian brain slices. Curr Dir Biomed Eng 9:375–378. doi:10.1515/cdbme-2023-1094

Garcia AJ, Zanella S, Koch H, Doi A, Ramirez JM. 2011. Networks within networks. The neuronal control of breathing. Prog Brain Res 188:31–50. doi:10.1016/B978-0-444-53825-3.00008-5

Hedrich UBS, Koch H, Becker A, Lerche H. 2019. Epileptogenesis and consequences for treatment. Nervenarzt. doi:10.1007/s00115-019-0749-8

Koch H, Garcia AJ, Ramirez JM. 2011. Network reconfiguration and neuronal plasticity in rhythm-generating networks. Integr Comp Biol 51:856–868. doi:10.1093/icb/icr099

Layer N, Müller P, Ayash M, Pfeiffer F, Saile M, Klopfer F, Iavarone S, Santuy A, Fallier-Becker
P, Hedrich UBS, Lerche H, Koch H, Wuttke T V. 2023. Axonopathy and altered synaptic development in early hippocampal epileptogenesis of Dravet syndrome. bioRxiv 2023.10.04.560735. doi:10.1101/2023.10.04.560735

Layer N, Sonnenberg L, Pardo González E, Benda J, Hedrich UBS, Lerche H, Koch H, Wuttke T V. 2021c. Dravet Variant SCN1AA1783V Impairs Interneuron Firing Predominantly by Altered Channel Activation. Front Cell Neurosci 15. doi:10.3389/fncel.2021.754530

Madisen L, Mao T, Koch H, Zhuo JM, Berenyi A, Fujisawa S, Hsu YWA, Garcia AJ, Gu X, Zanella S, Kidney J, Gu H, Mao Y, Hooks BM, Boyden ES, Buzsáki G, Ramirez JM, Jones AR, Svoboda K, Han X, Turner EE, Zeng H. 2012a. A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. Nat Neurosci 15:793–802. doi:10.1038/nn.3078

Marcuccilli CJ, Tryba AK, Van Drongelen W, Koch H, Viemari JC, Peña-Ortega F, Doren EL, Pytel P, Chevalier M, Mrejeru A, Kohrman MH, Lasky RE, Lew SM, Frim DM, Ramirez JM. 2010. Neuronal bursting properties in focal and parafocal regions in pediatric neocortical epilepsy stratified by histology. J Clin Neurophysiol 27:387–397. doi:10.1097/WNP.0b013e3181fe06d8

Martell A, Dwyer J, Koch H, Zanella S, Kohrman M, Frim D, Ramirez JM, Van Drongelen W. 2010. N-Methyl-d-Aspartate-Induced oscillatory properties in neocortical pyramidal neurons from patients with epilepsy. J Clin Neurophysiol 27:398–405. doi:10.1097/WNP.0b013e3182007c7d

Moya-Díaz J, Bayonés L, Montenegro M, Cárdenas AM, Koch H, Doi A, Marengo FD. 2020. Ca2+-independent and voltage-dependent exocytosis in mouse chromaffin cells. Acta Physiol 228. doi:10.1111/apha.13417

Quintana Albert, Zanella S, Koch H, Kruse SE, Lee D, Ramirez JM, Palmiter RD. 2012. Fatal breathing dysfunction in a mouse model of Leigh syndrome. J Clin Invest 122:2359–2368. doi:10.1172/JCI62923

Ramirez JM, Koch H, Garcia AJ, Doi A, Zanella S. 2011. The role of spiking and bursting pacemakers in the neuronal control of breathing. J Biol Phys 37:241–261. doi:10.1007/s10867-011-9214-z

Shea SD, Koch H, Baleckaitis D, Ramirez JM, Margoliash D. 2010. Neuron-specific cholinergic modulation of a forebrain song control nucleus. J Neurophysiol 103:733–745. doi:10.1152/jn.00803.2009

Theiss S, Maetzler W, Deuschle C, Lerche H, Koch H, Dihné M. 2017. Dementia with Lewy bodies: Cerebrospinal fluid suppresses neuronal network activity. Neuroreport 28:1061–1065. doi:10.1097/WNR.0000000000000890

Van Drongelen W, Koch H, Elsen FP, Lee HC, Mrejeru A, Doren E, Marcuccilli CJ, Hereld M, Stevens RL, Ramirez JM. 2006. Role of persistent sodium current in bursting activity of mouse neocortical networks in vitro. J Neurophysiol 96:2564–2577. doi:10.1152/jn.00446.2006

Van Drongelen W, Koch H, Marcuccilli C, Peña F, Ramirez JM. 2003. Synchrony levels during evoked seizure-like bursts in mouse neocortical slices. J Neurophysiol 90:1571–1580. doi:10.1152/jn.00392.2003

Yang D, Qi G, Ort J, Witzig V, Bak A, Delev D, Koch H, Feldmeyer D. 2023. Modulation of Giant Depolarizing Potentials (GDPs) in Human Large Basket Cells by Norepinephrine and Acetylcholine. bioRxiv 2023.01.02.522475. doi:10.1101/2023.01.02.522475

Yuste R, Hawrylycz M, Aalling N, Aguilar-Valles A, Arendt D, Armañanzas R, Ascoli GA, Bielza C, Bokharaie V, Bergmann TB, Bystron I, Capogna M, Chang YJ, Clemens A, de Kock CPJ, DeFelipe J, Dos Santos SE, Dunville K, Feldmeyer D, Fiáth R, Fishell GJ, Foggetti A, Gao X, Ghaderi P, Goriounova NA, Güntürkün O, Hagihara K, Hall VJ, Helmstaedter M, Herculano-Houzel S, Hilscher MM, Hirase H, Hjerling-Leffler J, Hodge R, Huang J, Huda R, Khodosevich K, Kiehn O, Koch H, Kuebler ES, Kühnemund M, Larrañaga P, Lelieveldt B, Louth EL, Lui JH, Mansvelder HD, Marin O, Martinez-Trujillo J, Chameh HM, Mohapatra AN, Munguba H, Nedergaard M, Němec P, Ofer N, Pfisterer UG, Pontes S, Redmond W, Rossier J, Sanes JR, Scheuermann RH, Serrano-Saiz E, Staiger JF, Somogyi P, Tamás G, Tolias AS, Tosches MA, García MT, Wozny C, Wuttke T V., Liu Y, Yuan J, Zeng H, Lein E. 2021 Classification and nomenclature of neocortical cell types (Nature Neuroscience, (2020), 23, 12, (1456-1468), 10.1038/s41593-020-0685-8). Nat Neurosci. doi:10.1038/s41593-020-00779-0