Publikationen

  • Heterozygous carriage of the alpha1-antitrypsin Pi*Z variant increases the risk to develop liver cirrhosis. (2019) Gut, doi: 10.1136/ gutjnl-2018-316228 
    • Strnad, P,. Buch, S., Hamesch, K., Fischer, J., Rosendahl, J., Schmelz, R., Brueckner, S., Brosch, M., Heimes, C.V., Woditsch, V., Scholten, D., Nischalke, H.D., Janciauskiene, S., Mandorfer, M., Trauner, M., Way, M.J., McQuillin, A., Reichert, M.C., Krawczyk, M., Casper, M., Lammert, F., Braun, F., von Schönfels, W., Hinz, S., Burmeister, G., Hellerbrand, C., Teufel, A., Feldman, A., Schattenberg, J.M., Bantel, H., Pathil, A., Muenevver, D., Kluwe, J., Boettler, T., Ridinger, M., Wodarz, N., Soyka, M., Rietschel, M., Kiefer, F., Weber, T., Marhenke, S., Vogel, A., Hinrichsen, H., Canbay, A., Schlattjan, M., Sosnowsky, K., Sarrazin, C., von Felden, J., Geier, A., Deltenre, P., Sipos, B., Schafmeyer, C., Nothnagel, M., Aigner, E., Datz, C., Stickel, F., Morgan, M.Y., Hampe, J., Berg, T., Trautwein, C.
       
  • Liver Fibrosis and Metabolic Alterations in Adults with Alpha1-Antitrypsin Deficiency Caused by the Pi*ZZ Mutation. (2019) Gastroenterology, doi: 10.1053/j.gastro.2019.05.013
    • Hamesch, K., Mandorfer, M., Pereira, V.M., Moeller, L.S., Pons, M., Dolman, G.E., Reichert, M.C., Heimes, C.V., Woditsch, V., Voss, J., Lindhauer, C., Fromme, M., Spivak, I., Guldiken, N., Zhou, B., Arslanow, A., Schaefer, B., Zoller, H., Aigner, E., Reiberger, T., Wetzel, M., Siegmund, B., Simoes, C., Gaspar, R., Maia, L., Costa, D., Bento-Miranda, M., van Helden, J., Yagmur, E., Bzdok, D., Stolk, J., Gleiber, W., Knipel, V., Windisch, W., Mahadeva, R., Bals, R., Koczulla, R., Barrecheguren, M., Miravitlles, M., Janciauskiene, S., Stickel, F., Lammert, F., Liberal, R., Genesca, J., Griffiths, W.J., Trauner, M., Krag, A., Trautwein, C., Strnad, P. 
  • Mild ironoverload as seen in individuals homozygous for the alpha-1 antitrypsin Pi*Z variant does not promote liver fibrogenesis in HFE knockout mice. (2019) Cells, doi: 10.3390/cells8111415
    • Guldiken, N., Hamesch, K., Schuller, S.M., Aly, M., Lindhauer, C., Schneider, C.V., Fromme, M., Trautwein, C., Strnad, P.
       
  • DEFI-Alpha: The French Key to the Alpha1 Mystery?, (2019) Liver Int., doi: 10.1111/liv.14064
    • Fromme, M., Oliverius, M., Strnad, P.
       
  • Assessment of liver phenotype in adults with severe alpha-1 antitrypsin deficiency (Pi*ZZ genotype). (2019) J Hepatol., doi: 10.1016/j.jhep.2019.08.011
    • Kümpers, J., Fromme, M., Schneider C.V., Trautwein, C., Denk, H., Hamesch, K., Strnad, P.
       
  • Alpha1-Antitrypsin Deficiency. (2020) New England Journal of Medicine, doi: 10.1056/NEJMra1910234
    • Strnad, P., McElvaney, N.G., Lomas, D.A.
       
  • Liver phenotype of European Adults heterozygous or homozygous for Pi*Z variant of AAT (Pi*MZ vs Pi*ZZ genotype) and Non-Carriers. (2020) Gastroenterology, doi: 10.1053/j.gastro.2020.04.058
    • Schneider, C.V., Hamesch, K., Gross, A., Mandorfer, M., Moeller, L.S., Pereira, V., Pons, M., Kuca, P., Reichert, M.C., Benini, F., Burbaum, B., Voss, J., Gutberlet, M., Woditsch, V., Lindhauer, C., Fromme, M., Kümpers, J., Bewersdorf, L., Schaefer, B., Eslam, M., Bals, R., Janciauskiene, S., Carvao, J., Neureiter, D., Zhou, B., Wöran, K., Bantel, H., Geier, A., Dirrichs, T., Stickel, F., Teumer, A., Verbeek, J., Nevens, F., Govaere, O., Krawczyk, M., Roskams, T., Haybaeck, J., Lurje, G., Chorostowska-Wynimko, J., Genesca, J., Reiberger, T., Lammert, F., Krag, A., George, J., Anstee Q.M., Trauner, M., Datz, C., Gaisa, N.T., Denk, H., Trautwein, C., Aigner, E., Strnad, P.
       
  • ARO-AAT reduces serum and intra-hepatic Z-AAT protein in PiZZ alpha-1 antitrypsin deficient patients with liver disease leading to improvements in clinically relevant liver biomarkers. AASLD The Liver Meeting Digital Experience 2020.
    • Strnad, P., Mandorfer, M., Choudhury, G., Griffiths, W., Turner, A.M., Trautwein, C., et al.
       
  • Hepatobiliary phenotypes of adults with alpha-1 antitrypsin deficiency. (2021)Gut, doi: 10.1136/gutjnl-2020-323729
    • Fromme, M., Schneider, C.V., Pereira, V., Hamesch, K., Pons, M., Reichert, M.C., Benini, F., Ellis, P., Thorhauge, K., Mandorfer, M., Burbaum, B., Woditsch, V., Chorostowska-Wynimko, J., Verbeek, J., Nevens, F., Genesca, J., Miravitlles, M., Nunez, A., Schaefer, B., Zoller, H., Janciauskiene, S., Abreu, N., Jasmins, L., Gaspar, R., Liberal, R., Macedo, G., Mahadeva, R., Gomes, C., Schneider, K.M., Trauner, M., Krag, A., Gooptu, B., Thorburn, D., Marshall, A., Hurst, J.R., Lomas, D.A., Lammert, F., Gaisa, N.T., Clark, V., Griffiths, W., Trautwein, C., Turner, A.M., McElvaney, N.G., Strnad, P.
       
  • Alpha1-antitrypsin deficiency: New therapies on the horizon. (2021) CurrOpin Pharmacol, doi:10.1016/j.coph.2021.06.001
    • Remih, K., Amzou, S., Strnad, P.
       
  • SARS-CoV-2 infektion in alpha1-antitrypsin deficiency. (2021) Respir Med, doi: 10.1016/j.rmed.2021.106466
    • Schneider C.V., Strnad, P.
       
  • Alpha-1 antitrypsin deficiency: a re-surfacing liver disorder. (2021) J Hepatol, doi: 10.1016/j.hep.2021.11.022
    • Fromme, M., Schneider, C.V., Trautwein, C., Brunetti-Pierri, N., Strnad, P.
  • Fazirsiran for Liver Disease Associated with Alpha1-Antitrypsin Deficiency. (2022) New England Journal of Medicine, doi: 10.1056/NEJMoa2205416
    • Pavel Strnad, M.D., Mattias Mandorfer, M.D., Ph.D., Gourab Choudhury, M.D., William Griffiths, M.D., Christian Trautwein, M.D., Rohit Loomba, M.D., Thomas Schluep, Sc.D., Ting Chang, Ph.D., Min Yi, Ph.D., Bruce D. Given, M.D., James C. Hamilton, M.D., Javier San Martin, M.D., and Jeffery H. Teckman, M.D