PD Dr. rer. nat. Patrick Ziegler

pzieglerukaachende 
Pauwelsstraße 30, 52074 Aachen
Raum 11 (Etage 3, Aufzug D2, Gang D)
Tel.: 0241 80-35841
Fax: 0241 80-82587

Weitere Informationen

Kurzbiografie

Ausbildung

1999-2002Dr. rer. nat. Ernst-Moritz-Arndt Universität Greifswald
1993-1998Studium Diplom-Biologie Eberhard-Karls Universität Tübingen und Ernst-Moritz-Arndt Universität Greifswald

 

Beruflicher Werdegang

Seit 2015Leiter der Arbeitsgruppe molekulare Arbeitsmedizin am Institut für Arbeits-, Sozial- und Umweltmedizin der Uniklinik RWTH Aachen
2010-2015Leiter der Arbeitsgruppe mesenchymale Stammzellen und inflammatorische Hämatopoese an der Klinik für Hämatologie, Onkologie, Hämostaseologie und Stammzelltransplantation der Uniklinik RWTH Aachen
2006-2009Postdoc am Institute For Research in Biomedicine in Bellinzona, Schweiz
2003-2005Wissenschaftlicher Assistent experimentelle Hämatologie an der Klinik für Onkologie, Hämatologie, Klinische Immunologie, Rheumatologie und Pulmologie der Eberhard-Karls Universität Tübingen

 

Forschungsschwerpunkte

  • Immunsupprimierende Wirkung polychlorierter Biphenyle

Publikationen

  • Kaifie A, Schettgen T, Gube M, Ziegler P, Kraus T, Esser A. Functional and structural liver abnormalities in former PCB exposed workers - analyses from the HELPcB cohort. J Toxicol Environ Health A. 2018 Dec 10:1-10. doi: 10.1080/15287394.2018.1555728. [Epub ahead of print] PubMed PMID: 30526399.
  • Vasko T, Hoffmann J, Gostek S, Schettgen T, Quinete N, Preisinger C, Kraus T, Ziegler P. Telomerase gene expression bioassays indicate metabolic activation of genotoxic lower chlorinated polychlorinated biphenyls. Sci Rep. 2018 Nov 15;8(1):16903. doi: 10.1038/s41598-018-35043-w. PubMed PMID: 30443001; PubMed Central PMCID: PMC6237825.
  • Kaifie A, Schikowsky C, Vasko T, Kraus T, Brümmendorf TH, Ziegler P. Additional benefits of telomere length (TL) measurements in chronic lymphocytic leukemia. Leuk Lymphoma. 2018 Jul 3:1-3. doi: 10.1080/10428194.2018.1482544. [Epub ahead of print] PubMed PMID: 29966475.
  • Andert A, Alizai HP, Ulmer TF, Heidenhain C, Ziegler P, Brümmendorf TH, Neumann UP, Beier F, Klink CD. Influence of Telomere Length in Hepatocytes on Liver Regeneration after Partial Hepatectomy in Rats. Eur Surg Res. 2018;59(1-2):83-90. doi: 10.1159/000489090. Epub 2018 Jun 8. PubMed PMID: 29886505.
  • Vasko T, Kaifie A, Stope MB, Kraus T, Ziegler P. Telomeres and Telomerase in Hematopoietic Dysfunction: Prognostic Implications and Pharmacological Interventions. Int J Mol Sci. 2017 Oct 28;18(11). pii: E2267. doi: 10.3390/ijms18112267. Review. PubMed PMID: 29143804; PubMed Central PMCID: PMC5713237.
  • Ventura Ferreira MS, Crysandt M, Ziegler P, Hummel S, Wilop S, Kirschner M, Schemionek M, Jost E, Wagner W, Brümmendorf TH, Beier F. Evidence for a pre-existing telomere deficit in non-clonal hematopoietic stem cells in patients with acute myeloid leukemia. Ann Hematol. 2017 Sep;96(9):1457-1461. doi: 10.1007/s00277-017-3049-z. Epub 2017 Jul 3. PubMed PMID: 28674830.
  • Ahrend H, Kaul A, Ziegler S, Brandenburg LO, Zimmermann U, Mustea A, Burchardt M, Ziegler P, Stope MB. MicroRNA-1 and MicroRNA-21 Individually Regulate Cellular Growth of Non-malignant and Malignant Renal Cells. In Vivo. 2017 Jul-Aug;31(4):625-630. PubMed PMID: 28652429; PubMed Central PMCID: PMC5566912.
  • Müller-Newen G, Stope MB, Kraus T, Ziegler P. Development of platelets during steady state and inflammation. J Leukoc Biol. 2017 May;101(5):1109-1117. doi: 10.1189/jlb.1RU0916-391RR. Epub 2017 Feb 24. Review. PubMed PMID: 28235774.
  • Caspar A, Mostertz J, Leymann M, Ziegler P, Evert K, Evert M, Zimmermann U, Brandenburg LO, Burchardt M, Stope MB. In Vitro Cultivation of Primary Prostate Cancer Cells Alters the Molecular Biomarker Pattern. In Vivo. 2016 09-10;30(5):573-9. PubMed PMID: 27566074.
  • Ziegler S, Schettgen T, Beier F, Wilop S, Quinete N, Esser A, Masouleh BK, Ferreira MS, Vankann L, Uciechowski P, Rink L, Kraus T, Brümmendorf TH, Ziegler P. Accelerated telomere shortening in peripheral blood lymphocytes after occupational polychlorinated biphenyls exposure. Arch Toxicol. 2017 Jan;91(1):289-300. doi: 10.1007/s00204-016-1725-8. Epub 2016 May 5. PubMed PMID: 27146145; PubMed Central PMCID: PMC5225163.
  • Weiss M, Ahrend H, Grossebrummel H, Ziegler P, Brandenburg LO, Walther R, Zimmermann U, Burchardt M, Stope MB. Cytochrome P450 17A1 Inhibitor Abiraterone Acetate Counteracts the Heat Shock Protein 27's Cell Survival Properties in Prostate Cancer Cells. Urol Int. 2016;97(1):112-7. doi: 10.1159/000445251. Epub 2016 Mar 24. PubMed PMID: 27007943.
  • Haase H, Fahlenkamp A, Schettgen T, Esser A, Gube M, Ziegler P, Kraus T, Rink L. Immunotoxicity Monitoring in a Population Exposed to Polychlorinated Biphenyls. Int J Environ Res Public Health. 2016 Mar 8;13(3). pii: E295. doi: 10.3390/ijerph13030295. PubMed PMID: 27005643; PubMed Central PMCID: PMC4808958.
  • Rauschenberger L, Staar D, Thom K, Scharf C, Venz S, Homuth G, Schlüter R, Brandenburg LO, Ziegler P, Zimmermann U, Weitschies W, Völker U, Lendeckel U, Walther R, Burchardt M, Stope MB. Exosomal particles secreted by prostate cancer cells are potent mRNA and protein vehicles for the interference of tumor and tumor environment. Prostate. 2016 Mar;76(4):409-24. doi: 10.1002/pros.23132. Epub 2015 Dec 8. PubMed PMID: 26643154.
  • Ziegler P, Boettcher S, Takizawa H, Manz MG, Brümmendorf TH. LPS-stimulated human bone marrow stroma cells support myeloid cell development and progenitor cell maintenance. Ann Hematol. 2016 Jan;95(2):173-8. doi: 10.1007/s00277-015-2550-5. Epub 2015 Nov 11. PubMed PMID: 26555286.
  • Hummel S, Ventura Ferreira MS, Heudobler D, Huber E, Fahrenkamp D, Gremse F, Schmid K, Müller-Newen G, Ziegler P, Jost E, Blasco MA, Brümmendorf TH, Holler E, Beier F. Telomere shortening in enterocytes of patients with uncontrolled acute intestinal graft-versus-host disease. Blood. 2015 Nov 26;126(22):2518-21. doi: 10.1182/blood-2015-03-633289. Epub 2015 Oct 20. PubMed PMID: 26486788.
  • Beier F, Masouleh BK, Buesche G, Ventura Ferreira MS, Schneider RK, Ziegler P, Wilop S, Vankann L, Gattermann N, Platzbecker U, Giagounidis A, Götze KS, Nolte F, Hofmann WK, Haase D, Kreipe H, Panse J, Blasco MA, Germing U, Brümmendorf TH. Telomere dynamics in patients with del (5q) MDS before and under treatment with lenalidomide. Leuk Res. 2015 Sep 21. pii: S0145-2126(15)30380-5. doi: 10.1016/j.leukres.2015.09.003. [Epub ahead of print] PubMed PMID: 26427727.
  • Wenn K, Tomala L, Wilop S, Vankann L, Hasenbank C, Frank O, Hochhaus A, Giles FJ, Lange T, Müller MC, Koschmieder S, Beier F, Ziegler P, Brümmendorf TH. Telomere length at diagnosis of chronic phase chronic myeloid leukemia (CML-CP) identifies a subgroup with favourable prognostic parameters and molecular response according to the ELN criteria after 12 months of treatment with nilotinib. Leukemia. 2015 Dec;29(12):2402-4. doi: 10.1038/leu.2015.245. Epub 2015 Sep 15. PubMed PMID: 26369986.
  • Weiss M, Gümbel D, Gelbrich N, Brandenburg LO, Mandelkow R, Zimmermann U, Ziegler P, Burchardt M, Stope MB. Inhibition of Cell Growth of the Prostate Cancer Cell Model LNCaP by Cold Atmospheric Plasma. In Vivo. 2015 Sep-Oct;29(5):611-6. PubMed PMID: 26359422.
  • Schumacher A, Denecke B, Braunschweig T, Stahlschmidt J, Ziegler S, Brandenburg LO, Stope MB, Martincuks A, Vogt M, Görtz D, Camporeale A, Poli V, Müller-Newen G, Brümmendorf TH, Ziegler P. Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors,
  • and accelerates reconstitution of platelets after myelosuppressive therapy. J Hematol Oncol. 2015 Jun 9;8:64. doi: 10.1186/s13045-015-0152-2. PubMed PMID: 26054961; PubMed Central PMCID: PMC4460974.
  • Emontzpohl C, Goetzenich A, Simons D, Kraemer S, Dewor M, Lue H, Hammer L, Jacobs D, Grieb G, Ziegler P, Panse J, Rossaint R, Bernhagen J, Stoppe C. Key role of MIF in the migration of endothelial progenitor cells in patients during cardiac surgery. Int J Cardiol. 2015 Feb 15;181:284-7. doi: 10.1016/j.ijcard.2014.11.226. Epub 2014 Dec 18. PubMed PMID: 25535692.
  • Schneider RK, Ziegler S, Leisten I, Ferreira MS, Schumacher A, Rath B, Fahrenkamp D, Müller-Newen G, Crysandt M, Wilop S, Jost E, Koschmieder S, Knüchel R, Brümmendorf TH, Ziegler P. Activated fibronectin-secretory phenotype of mesenchymal stromal cells in pre-fibrotic myeloproliferative neoplasms. J Hematol Oncol. 2014 Dec 14;7:92. doi: 10.1186/s13045-014-0092-2. PubMed PMID: 25498831; PubMed Central PMCID: PMC4271470.
  • Weidner CI, Ziegler P, Hahn M, Brümmendorf TH, Ho AD, Dreger P, Wagner W. Epigenetic aging upon allogeneic transplantation: the hematopoietic niche does not affect age-associated DNA methylation. Leukemia. 2015 Apr;29(4):985-8. doi: 10.1038/leu.2014.323. Epub 2014 Nov 12. PubMed PMID: 25388956.
  • Stope MB, Stender C, Schubert T, Peters S, Weiss M, Ziegler P, Zimmermann U, Walther R, Burchardt M. Heat-shock protein HSPB1 attenuates microRNA miR-1 expression thereby restoring oncogenic pathways in prostate cancer cells. Anticancer Res. 2014 Jul;34(7):3475-80. PubMed PMID: 24982356.
  • Heuser M, Schlarmann C, Dobbernack V, Panagiota V, Wiehlmann L, Walter C, Beier F, Ziegler P, Yun H, Kade S, Kirchner A, Huang L, Koenecke C, Eder M, Brümmendorf TH, Dugas M, Ganser A, Thol F. Genetic characterization of acquired aplastic anemia by targeted sequencing. Haematologica. 2014 Sep;99(9):e165-7. doi: 10.3324/haematol.2013.101642. Epub 2014 Jun 6. PubMed PMID: 24907358; PubMed Central PMCID: PMC4562551.
  • Weidner CI, Lin Q, Koch CM, Eisele L, Beier F, Ziegler P, Bauerschlag DO, Jöckel KH, Erbel R, Mühleisen TW, Zenke M, Brümmendorf TH, Wagner W. Aging of blood can be tracked by DNA methylation changes at just three CpG sites. Genome Biol. 2014 Feb 3;15(2):R24. doi: 10.1186/gb-2014-15-2-r24. PubMed PMID: 24490752; PubMed Central PMCID: PMC4053864.
  • Hauber I, Hofmann-Sieber H, Chemnitz J, Dubrau D, Chusainow J, Stucka R, Hartjen P, Schambach A, Ziegler P, Hackmann K, Schröck E, Schumacher U, Lindner C, Grundhoff A, Baum C, Manz MG, Buchholz F, Hauber J. Highly significant antiviral activity of HIV-1 LTR-specific tre-recombinase in humanized mice. PLoS Pathog. 2013;9(9):e1003587. doi: 10.1371/journal.ppat.1003587. Epub 2013 Sep 26. PubMed PMID: 24086129; PubMed Central PMCID: PMC3784474.
  • Stope MB, Rönnau C, Schubert T, Staar D, Bradl J, Ziegler P, Streitbörger A, Kroeger N, Zimmermann U, Walther R, Burchardt M, Börgermann C. [Transforming growth factor β in prostate cancer: cellular effects and basic molecular mechanisms]. Urologe A. 2013 Mar;52(3):378-83. doi: 10.1007/s00120-012-3049-5. German. PubMed PMID: 23160607.
  • Koch CM, Reck K, Shao K, Lin Q, Joussen S, Ziegler P, Walenda G, Drescher W, Opalka B, May T, Brümmendorf T, Zenke M, Saric T, Wagner W. Pluripotent stem cells escape from senescence-associated DNA methylation changes. Genome Res. 2013 Feb;23(2):248-59. doi: 10.1101/gr.141945.112. Epub 2012 Oct 18. PubMed PMID: 23080539; PubMed Central PMCID: PMC3561866.
  • Chatain N, Ziegler P, Fahrenkamp D, Jost E, Moriggl R, Schmitz-Van de Leur H, Müller-Newen G. Src family kinases mediate cytoplasmic retention of activated STAT5 in BCR-ABL-positive cells. Oncogene. 2013 Aug 1;32(31):3587-97. doi: 10.1038/onc.2012.369. Epub 2012 Aug 27. PubMed PMID: 22926520.
  • Boettcher S, Ziegler P, Schmid MA, Takizawa H, van Rooijen N, Kopf M, Heikenwalder M, Manz MG. Cutting edge: LPS-induced emergency myelopoiesis depends on TLR4-expressing nonhematopoietic cells. J Immunol. 2012 Jun 15;188(12):5824-8. doi: 10.4049/jimmunol.1103253. Epub 2012 May 14. PubMed PMID: 22586037.
  • Ziegler P, Schrezenmeier H, Akkad J, Brassat U, Vankann L, Panse J, Wilop S, Balabanov S, Schwarz K, Martens UM, Brümmendorf TH. Telomere elongation and clinical response to androgen treatment in a patient with aplastic anemia and a heterozygous hTERT gene mutation. Ann Hematol. 2012 Jul;91(7):1115-20. doi: 10.1007/s00277-012-1454-x. Epub 2012 Apr 4. PubMed PMID: 22476886.
  • Ziegler P, Chahoud T, Wilhelm T, Pällman N, Braig M, Wiehle V, Ziegler S, Schröder M, Meier C, Kolodzik A, Rarey M, Panse J, Hauber J, Balabanov S, Brümmendorf TH. Evaluation of deoxyhypusine synthase inhibitors targeting BCR-ABL positive leukemias. Invest New Drugs. 2012 Dec;30(6):2274-83. doi: 10.1007/s10637-012-9810-1. Epub 2012 Mar 14. PubMed PMID: 22415796.
  • Leisten I, Kramann R, Ventura Ferreira MS, Bovi M, Neuss S, Ziegler P, Wagner W, Knüchel R, Schneider RK. 3D co-culture of hematopoietic stem and progenitor cells and mesenchymal stem cells in collagen scaffolds as a model of the hematopoietic niche. Biomaterials. 2012 Feb;33(6):1736-47. doi: 10.1016/j.biomaterials.2011.11.034. Epub 2011 Dec 1. PubMed PMID: 22136713.
  • Ziegler P, Teller S, Ha NH, Giese B, Fraunholz M, Walther R. Phosphoproteomic identification of a PDX-1/14-3-3ε interaction in pancreatic beta cells. Horm Metab Res. 2011 Mar;43(3):165-70. doi: 10.1055/s-0030-1270526. Epub 2011 Feb 1. PubMed PMID: 21287435.
  • Neagu MR, Ziegler P, Pertel T, Strambio-De-Castillia C, Grütter C, Martinetti G, Mazzucchelli L, Grütter M, Manz MG, Luban J. Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components. J Clin Invest. 2009 Oct;119(10):3035-47. doi: 10.1172/JCI39354. Epub 2009 Sep 8. PubMed PMID: 19741300; PubMed Central PMCID: PMC2752079.
  • Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, Debarry J, de Jong Y, Deng H, Di Santo JP, Eisenbarth S, Eynon E, Flavell RA, Guzman CA, Huntington ND, Kremsdorf D, Manns MP, Manz MG, Mention JJ, Ott M, Rathinam C, Rice CM, Rongvaux A, Stevens S, Spits H, Strick-Marchand H, Takizawa H, van Lent AU, Wang C, Weijer K, Willinger T, Ziegler P. Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host Microbe. 2009 Jul 23;6(1):5-9. doi: 10.1016/j.chom.2009.06.006. Review. PubMed PMID: 19616761.
  • Martinez Soria N, Tussiwand R, Ziegler P, Manz MG, Heidenreich O. Transient depletion of RUNX1/RUNX1T1 by RNA interference delays tumour formation in vivo. Leukemia. 2009 Jan;23(1):188-90. doi: 10.1038/leu.2008.157. Epub 2008 Jun 12. PubMed PMID: 18548094.
  • Baenziger S, Ziegler P, Mazzucchelli L, Bronz L, Speck RF, Manz MG. Human T cell development and HIV infection in human hemato-lymphoid system mice. Curr Top Microbiol Immunol. 2008;324:125-31. Review. PubMed PMID: 18481457.
  • Ziegler P, Manz MG. Mouse models for human hemato-lymphopoiesis. Curr Protoc Toxicol. 2007 Feb;Chapter 2:Unit2.13. doi: 10.1002/0471140856.tx0213s31. PubMed PMID: 20941704.
  • Balabanov S, Gontarewicz A, Ziegler P, Hartmann U, Kammer W, Copland M, Brassat U, Priemer M, Hauber I, Wilhelm T, Schwarz G, Kanz L, Bokemeyer C, Hauber J, Holyoake TL, Nordheim A, Brümmendorf TH. Hypusination of eukaryotic initiation factor 5A (eIF5A): a novel therapeutic target in BCR-ABL-positive leukemias identified by a proteomics approach. Blood. 2007 Feb 15;109(4):1701-11. Epub 2006 Sep 28. PubMed PMID: 17008552.
  • Hartmann U, Balabanov S, Ziegler P, Fellenberg J, van der Kuip H, Duyster J, Lipp HP, Bokemeyer C, Kanz L, Brümmendorf TH. Telomere length and telomerase activity in the BCR-ABL-transformed murine Pro-B cell line BaF3 is unaffected by treatment with imatinib. Exp Hematol. 2005 May;33(5):542-9. PubMed PMID: 15850831.
  • Hessabi B, Ziegler P, Schmidt I, Hessabi C, Walther R. The nuclear localization signal (NLS) of PDX-1 is part of the homeodomain and represents a novel type of NLS. Eur J Biochem. 1999 Jul;263(1):170-7. PubMed PMID: 10429201.