Univ.-Prof. Dr. med. Tim H. Brümmendorf

Spezialgebiete

Akute und chronische Leukämien

Maligne Lymphome

Molekular zielgerichtete Therapie

Wissenschaftliche Schwerpunkte

Telomerbiologie der Hämatopoese

Stammzellbiologie der Hämatopoese

Kinaseinhibitoren in der Therapie hämatologischer Neoplasien

Hypusinierung und der eukaryontische Initiationsfaktor 5a (eIF5a)

Ausgewählte Publikationen

Marsh JC, Bacigalupo A, Schrezenmeier H, Tichelli A, Risitano AM, Passweg JR, Killik SB, Warren AJ, Foukaneli T, Aljurf M, Al-Zahrani HA, Schafhausen P, Roth A, Franzke A, Brummendorf TH, Dufour C, Oneto R, Sedgwick P, Barrois A, Kordasti S, Elebute MO, Mufti GJ, Socie G (2012) Prospective study of rabbit antithymocyte globulin and ciclosporin for aplastic anemia from the EBMT Severe Aplastic Anemia Working Party. Blood, (DOI)10.1182/blood-2012-02-407684

houry HJ, Cortes JE, Kantarjian HM, Gambacorti-Passerini C, Baccarani M, Kim DW, Zaritskey A, Countouriotis A, Besson N, Leip E, Kelly V, Brummendorf TH (2012) Bosutinib is active in chronic phase chronic myeloid leukemia after imatinib and dasatinib and/or nilotinib therapiy failure. Blood 119(15):3403-12

Brassat U, Balabanov S, Bali D, Dierlamm J, Braig M, Hartmann U, Sirma H, Günes C, Wege H, Fehse B, Gontarewicz A, Dikomey E, Borgmann K, Brummendorf TH (2011) Functional p53 is required for effective execution of telo-merase inhibition in BCR-ABL-positive CML cells. Exp Hematol 39(1):66-76.e1-2.ccc

Wege H, Heim D, Lütgehetmann M, Dierlamm J, Lohse AW, Brummendorf TH (2011) Forced activation of (beta)-catenin signaling is sufficient to drive transforma-tion of hTERT-immortalized human fetal hepatocytes. Mol Cancer Res 9(9):1222-31

Bartolovic K, Balabanov S, Berner B, Bühring H-J, Komor M, Becker S, Hoelzer D, Kanz L, Hofmann W-K, Brummendorf TH (2005) Clonal heterogeneity in growth kinetics of CD34+38- human cord blood cells in vitro is correlated with gene expression pattern and telomere length. Stem Cells 23(7): 946-957