Lecture:
Prof. Dr. Stéphanie Portet, Theodore von Kármán Fellow, University of Manitoba
MOCA, Institute of Molecular and Cellular Anatomy, MTI 1, Rom 306
Intermediate filaments are one of the components of cytoskeletal networks that are involved in major functions in the cell. The cytoskeleton organizes via a series of polymerization and depolymerization events; the organization of cytoskeletal networks is the main determinant of their properties and functions in the cell. Understanding the assembly of intermediate filaments, their organization in networks and resulting mechanical properties is essential to elucidate their functions in cells. I will present computational and mathematical models of the complex processes of intermediate filament assembly and network organization.
