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Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy
The integrated stress response (ISR) converges on eIF2α phosphorylation to regulate protein synthesis. ISR is activated by several stress conditions, including endoplasmic reticulum (ER) stress,…
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Stimulus strength determines the BTK-dependence of the SHIP1- deficient phenotype in IgE/antigen-triggered mast cells
Antigen-mediated crosslinking of IgE-loaded high-affinity receptors for IgE (FcεRI) on mast cells triggers activation of proinflammatory effector functions relevant for IgE-associated allergic…
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Unexpected IgG-independent tyrosine phosphorylation of the inhibitory IgG receptor FcγRIIB in antigen/allergen-activated mast cells
The high-affinity receptor for IgE (FcγRI) is crucial for the IgE/antigen-triggered allergic activation of mast cells. This activation follows a so-called bell-shaped dose-response curve with weak…
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Finally a role of CD13/aminopeptidase N in myeloid cells: Negative regulation of mast cell activation in vitro and in vivo
CD13 (aminopeptidase N) is a type-II membrane protein with an extracellular zinc-dependent metalloprotease domain. CD13 was originally identified as a surface protein in myeloid cells, however, its…