Publikationen

• Gründer, S., Vanek, J., Pissas, KP 
  Acid-sensing ion channels and downstream signalling in cancer cells: is there a mechanistic link?
  Pfügers Archiv - European Journal of Physiology https://doi.org/10.1007/s00424-023-02902-z

• Pissas, K., Gründer, S., Tian Y.
  Functional expression of the proton sensors ASIC1a, TMEM206, and OGR1 together with BK_Ca channels is associated with cell volume changes and cell death under strongly acidic conditions in DAOY medulloblastoma cells
  Pflugers Arch. 2024 Jun. doi: 10.1007/s00424-024-02964-7.

• Mouzakis F, Kashefi A, Spillner J, Rütten S, Mottaghy K, Hima F
  A new approach towards extracorporeal gas exchange and first in vitro results
  Biomed Tech (Berl). 2023 Nov 7. doi: 10.1515/bmt-2023-0459. Online ahead of print.

• Hima F, Saunders A, Kashefi A, Mouzakis F, Mottaghy K, Spillner J, Zayat R, Kalverkamp S.
  In vitro evaluation of the performance of an oxygenator depending on the non-standard gas content of the inlet blood with special regard on CO2 elimination
  Perfusion 2023 Sep 22:2676591231204565. doi: 10.1177/02676591231204565.
• Hima F, Kalverkamp S, Kashefi A, Mottaghy K, Zayat R, Strudthoff L, Spillner J, Mouzakis F.
  Oxygenation performance assessment of an artificial lung in different central anatomic configurations
  Int J Artif Organs. 2023 May;46(5):295-302. doi: 10.1177/03913988231168163. Epub 2023 Apr 12.
• Pissas KP, Schilling M, Korkmaz, A, Tian Y, Gründer S.
  Melatonin alters the excitability of mouse cerebellar granule neurons by inhibiting voltage-gated sodium, potassium, and calcium channels
  Journal of Pineal Research 2023; DOI: 10.1111/jpi.12919
• Pissas KP, Schilling M, Tian Y, Gründer S.
  Functional characterization of acid-sensing ion channels in the cerebellum-originating medulloblastoma cell line DAOY and in cerebellar granule neurons.
  Pflugers Arch. 2023 Jul 20. doi: 10.1007/s00424-023-02839-3. Online ahead of print.
• Fischer L, Schmidt A, Dopychai A, Joussen S, Joeres N, Oslender-Bujotzek A, Schmalzing G, Gründer S.
  Physiologically relevant acid-sensing ion channel (ASIC) 2a/3 heteromers have a 1:2 stoichiometry.
  Commun Biol. 2023 Jul 8;6(1):701. doi: 10.1038/s42003-023-05087-4.
• Hawashin A, Brakmann IC, Tian Y, Gründer S, Ortega-Ramírez AM
  Modulation of Acid-Sensing Ion Channels by Tannic Acid and Green Tea via a Membrane-Mediated Mechanism.
  ACS Chem Neurosci. 2023 Jun 28. doi: 10.1021/acschemneuro.3c00032. Online ahead of print.
• Aguilar-Camacho JM, Foreman K, Jaimes-Becerra A, Aharoni R, Gründer S, Moran Y
  Functional analysis in a model sea anemone reveals phylogenetic complexity and a role in cnidocyte discharge of DEG/ENaC ion channels.
  Commun Biol. 2023 Jan 6;6(1):17. doi: 10.1038/s42003-022-04399-1.
• Cortés Franco KD, Brakmann IC, Feoktistova M, Panayotova-Dimitrova D, Gründer S, Tian Y
  Aggressive migration in acidic pH of a glioblastoma cancer stem cell line in vitro is independent of ASIC and K_Ca3.1 ion channels, but involves phosphoinositide 3-kinase.
  Pflugers Arch. 2023 Mar;475(3):405-416. doi: 10.1007/s00424-022-02781-w. Epub 2022 Dec 16.
• Gründer S, Ramírez AO, Jékely G
  Neuropeptides and degenerin/epithelial Na⁺ channels: a relationship from mammals to cnidarians.
  J Physiol. 2023 May;601(9):1583-1595. doi: 10.1113/JP282309. Epub 2022 Dec 8.

• Clusmann J, Franco KC, Suárez DAC, Katona I, Minguez MG, Boersch N, Pissas KP, Vanek J, Tian Y, Gründer S
  Acidosis induces RIPK1-dependent death of glioblastoma stem cells via acid-sensing ion channel 1a.
  Cell Death Dis. 2022; 13(8): . doi: 10.1038/s41419-022-05139-3 epublish
• Pournemati B, Tabesh H, Jenabi A, Aghdam RM, Rezayan AH, Poorkhalil A, Tafti SHA, Mottaghy K
  Injectable conductive nanocomposite hydrogels for cardiac tissue engineering: Focusing on carbon and metal-based nanostructures
  Eur Polym J. 2022; 174(): . doi: 10.1016/j.eurpolymj.2022.111336
• Mouzakis FL, Khadka LB, da Silva MP, Mottaghy K
  Quantification of dissolved H-2 and continuous monitoring of hydrogen-rich water for haemodialysis applications: An experimental study
  Int J Artif Organs. 2022; 45(3): 254-261. doi: 10.1177/03913988211070588
• Neupane B, Pradhan K, Ortega-Ramirez AM, Aidery P, Kucikas V, Marks M, van Zandvoort MAMJ, Klingel K, Witte KK, Gründer S, Marx N, Gramlich M
  Personalized Medicine Approach in a DCM Patient with LMNA Mutation Reveals Dysregulation of mTOR Signaling.
  J Pers Med. 2022; 12(7): . doi: 10.3390/jpm12071149 epublish
• Tabesh H, Poorkhalil A, Akbari H, Rafiei F, Mottaghy K
  Phenomenological characterization of blood's intermediate shear rate: a new concept for hemorheology
  Phys. Eng. Sci. Med.. 2022; 45(4): 1205-1217. doi: 10.1007/s13246-022-01188-2

• Shari Wiegreffe, Daniel Löhrer, Monika Wirtz, Dominik Wiemuth. "The bile acid-sensitive ion channel (BASIC) mediates bile acid-dependent currents in bile duct epithelial cells" Pflügers Archiv - European Journal of Physiology volume 473, pages1841–1850 (2021)
• Leisle L, Margreiter M, Ortega-Ramírez A, Cleuvers E, Bachmann M, Rossetti G, Gründer S. „Dynorphin Neuropeptides Decrease Apparent Proton Affinity of ASIC1a by Occluding the Acidic Pocket“ J Med Chem. 2021;64(18):13299-13311
• Bachmann M, Ortega-Ramírez A, Leisle L, Gründer S. “Efficient expression of a cnidarian peptide-gated ion channel in mammalian cells.” Channels (Austin) 2021 Dec;15(1):273-283. doi: 10.1080/19336950.2021.1882762.
• Kuspiel S, Wiemuth D, Gründer S. “The Neuropeptide Nocistatin Is Not a Direct Agonist of Acid-Sensing Ion Channel 1a (ASIC1a).” Biomolecules 2021 Apr 13;11(4):571. doi: 10.3390/biom11040571.
• Neuhof A, Tian Y, Reska A, Falkenburger B, Gründer S. “Large Acid-Evoked Currents, Mediated by ASIC1a, Accompany Differentiation in Human Dopaminergic Neurons.” Front Cell Neurosci 2021 Apr 27;15:668008. doi: 10.3389/fncel.2021.668008. eCollection 2021.
• Tabesh H, Rafiei F, Mottaghy K
  In silico simulation of the liquid phase pressure drop through cylindrical hollow-fiber membrane oxygenators using a modified phenomenological model
  Asia-Pacific journal of chemical engineering.. 2021; 16(3): . doi: 10.1002/apj.2633
• De Lazzari B, Iacovoni A, Mottaghy K, Capoccia M, Badagliacca R, Vizza CD, De Lazzari C
  ECMO Assistance during Mechanical Ventilation: Effects Induced on Energetic and Haemodynamic Variables
  Comput Methods Programs Biomed. 2021; 212(): . doi: 10.1016/j.cmpb.2021.106478
• Rafiei F, Tabesh H, Farzad S, Farzaneh F, Rezaei M, Hosseinzade F, Mottaghy K
  Development of Hormonal Intravaginal Rings: Technology and Challenges.
  Geburtsh Frauenheilk. 2021; 81(7): 789-806. doi: 10.1055/a-1369-9395ISSN0016-5751 ppublish
• Stegmayr B, Willems C , Groth T, Martins A, Neves NM, Mottaghy K, Remuzzi A, Walpoth B
  Arteriovenous access in hemodialysis: A multidisciplinary perspective for future solutions.
  Int J Artif Organs. 2021; 44(1): 3-16. doi: 10.1177/0391398820922231 ppublish

• Tian Y, Korn P, Tripathi P, Komnig D, Wiemuth D, Nikouee A, Classen A , Bolm C, Falkenburger BH, Lüscher B, Gründer S
  The mono-ADP-ribosyltransferase ARTD10 regulates the voltage-gated K channel Kv1.1 through protein kinase C delta.
  BMC Biol. 2020; 18(1): 143. doi: 10.1186/s12915-020-00878-1 epublish
• Leisle L, Xu YY, Lee S, Galpin JD, Vien M, Ahern CA, Accardi A, Berneche S
  Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels
  Elife. 2020; 9(): . doi: 10.7554/eLife.51224

2019

• Schmidt A, Joussen S, Hausmann R, Gründer S, Wiemuth D
  Bile acids are potent inhibitors of rat P2X2 receptors
  Purinergic Signal 2019, 15(2): 213-221
  https://pubmed.ncbi.nlm.nih.gov/31098843/
• Tabesh H, Gholami,, Torabi D, Mottaghy K
  A pH-based experimental method for carbon dioxide exchange evaluation in cylindrical hollow fiber membrane oxygenators
  Asia-Pacific journal of chemical engineering. 2019; 14(4): UNSP e2337-. doi: 10.1002/apj.2337
• Poorkhalil A, Mouzakis F, Kashefi A, Mottaghy K
  The course of hematocrit value along the length of a dialyzer's fiber: Hemoconcentration modeling and validation methods.
  Int J Artif Organs. 2019; 42(9): 482-489. doi: 10.1177/0391398819847214 ppublish