PD Dr. Dominik Wiemuth

Lebenslauf

1997 - 2002
Studium der Biologie, Schwerpunkt Molekularbiologie und Biochemie, Universität Mainz

2003 - 2006
Doktorarbeit am Department of Physiology, AG Fiona J. McDonald, University of Otago, New Zealand

06/2006
PhD in Physiology, Thema: Regulation of the Epithelial Sodium Channel (ENaC) by Ubiquitination

07/2006 - 03/2008
Wissenschaftlicher Mitarbeiter am Physiologischen Institut, Universität Würzburg 

seit 04/2008
Wissenschaftlicher Mitarbeiter am Physiologischen Institut, Universitätsklinikum Aachen

06/2015
Habilitation für das Fach Physiologie

Arbeitsgebiete

• Protonen-aktivierte Ionenkanäle (Acid-sensing ion channels)
• TRP Kanäle
• Bile Acid-Sensitive Ion Channel (BASIC)

Publikationen

1. Schmidt A, Löhrer D, Alsop RJ, Lenzig P, Oslender-Bujotzek A, Wirtz M, Rheinstädter MC, Gründer S, Wiemuth D.
   A Cytosolic Amphiphilic α-Helix Controls the Activity of the Bile Acid-sensitive Ion Channel (BASIC).
   J Biol Chem. 2016 Nov 18;291(47):24551-24565.
2. Hendriks CM, Penning TM, Zang T, Wiemuth D, Gründer S, Sanhueza IA, Schoenebeck F, Bolm C.
   Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities.
   Bioorg Med Chem Lett. 2015 Oct 15;25(20):4437-40. doi: 10.1016/j.bmcl.2015.09.012.
3. Schmidt, A., Lenzig, P., Oslender-Bujotzek, A., Kusch, J., Dias Lucas, S., Gründer, S., and Wiemuth, D. (2014)
   The bile acid-sensitive ion channel (BASIC) is activated by alterations of its membrane Environment.
   PLoS One 9, e111549.
4. Wiemuth, D., Assmann, M., and Gründer, S. (2014)
   The bile acid-sensitive ion channel (BASIC), the neglected cousin of ASICs and ENaC.
   Channels (Austin) 8, 29-34.
5. Wiemuth, D., Lefevre, C. M., Heidtmann, H., and Gründer, S. (2014)
   Bile acids increase the activity of the epithelial Na+ hannel.
   Pflugers Arch 466, 1725-1733.
6. Vollrath, J. T., Sechi, A., Dreser, A., Katona, I., Wiemuth, D., Vervoorts, J., Dohmen, M., Chandrasekar, A., Prause, J., Brauers, E., Jesse, C. M., Weis, J., and Goswami, A. (2014)
   Loss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbances.
   Cell death & disease 5, e1290.
7. Lefevre, C. M., Diakov, A., Haerteis, S., Korbmacher, C., Gründer, S., and Wiemuth, D. (2014) Pharmacological and electrophysiological characterization of the human bile acid-sensitive ion channel (hBASIC). Pflugers Arch 466, 253-263 
8. Wiemuth D, Sahin H, Lefèvre CM, Wasmuth H, Gründer S.
   Strong activation of bile acid-sensitive ion channel (BASIC) by ursodeoxycholic acid.
   Channels (Austin). 2012 Oct 12;7(1). [Epub ahead of print]
9. Wiemuth D, van de Sandt L, Herr R, Gründer S. (2012)
   Transient receptor potential N (TRPN1) from Xenopus interacts with the penta-EF-hand protein peflin
   FEBS Letters 586 (2012) 4276–4281
10. Wiemuth D, Sahin H, Falkenburger BH, Lefèvre CM, Wasmuth HE, Gründer S (2012)
    BASIC-a bile acid-sensitive ion channel highly expressed in bile ducts.
    FASEB J. 26(10), 4122-30
11. Wiemuth D, Gründer S (2011)
    The pharmacological profile of brain liver intestine Na+ channel (BLINaC): inhibition by diarylamidines and activation by fenamates.  
    Mol Pharmacol, 80(5), 911–919
12. Wiemuth D, Gründer S. (2010)
    A single amino acid tunes Ca2+ inhibition of brain liver intestine Na+ channel(BLINaC). 
    J Biol Chem, 285(40), 30404-10
13. Wiemuth D, Lott JS, Ly K, Ke Y, Teesdale-Spittle P, Snyder PM, McDonald FJ. (2010) Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation. 
    PLoS One, 5(8):e12163.
14. Wiemuth D, Ke Y, Rohlfs M und McDonald FJ (2007)
    Epithelialsodiumchannel (ENaC) is multiubiquitinated at the cell surface. 
    Biochem J, 405 (1):147:55