Arbeitsgruppe onkologische CT-Diagnostik
Zur Beurteilung des Therapieansprechens bei Krebserkrankungen spielt im klinischen Alltag genauso wie in onkologischen Zulassungs- und Therapiestudien die radiologisch-morphologische Beurteilung eine zentrale Rolle, welche zumeist durch die kontrastverstärkte Computertomographie erfolgt. Bisherige wissenschaftliche Arbeiten konnten zeigen, dass herkömmliche Tumorevaluierungskriterien (RECIST 1.0 bzw. 1.1) hierbei deutliche Limitationen aufweisen können.
Ziel unserer Arbeitsgruppe ist es, Evaluierungsverfahren zu entwickeln und voranzutreiben, die eine bessere Beurteilung der Tumormasse und des onkologischen Therapieansprechens erlauben, z.B. über das Ganzkörper-bezogene Tumorvolumen („whole-body tumor volume – WBTV“).
Forschungsschwerpunkte:
- Entwicklung, systematische klinische Validierung und Implementierung von Computer-Algorithmen zur Computer-assistierten Diagnose (CAD)
Kooperationspartner:
- Siemens Healthcare AG
Aktuelle Publikationen:
Truhn D, Tayebi Arasteh S, Saldanha OL, Müller-Franzes G, Khader F, Quirke P, West NP, Gray R, Hutchins GGA, James JA, Loughrey MB, Salto-Tellez M, Brenner H, Brobeil A, Yuan T, Chang-Claude J, Hoffmeister M, Foersch S, Han T, Keil S, Schulze-Hagen M, Isfort P, Bruners P, Kaissis G, Kuhl C, Nebelung S, Kather JN
Encrypted federated learning for secure decentralized collaboration in cancer image analysis.
In: Medical image analysis
Khader F, Han T, Müller-Franzes G, Huck L, Schad P, Keil S, Barzakova E, Schulze-Hagen M, Pedersoli F, Schulz V, Zimmermann M, Nebelung L, Kather J, Hamesch K, Haarburger C, Marx G, Stegmaier J, Kuhl C, Bruners P, Nebelung S, Truhn D
Artificial Intelligence for Clinical Interpretation of Bedside Chest Radiographs.
In: Radiology
Siepmann R, Bruners P, Lang SA, Bednarsch J, Amygdalos I, Joechle K, Pedersoli F, Keil S, Isfort P, Ulmer TF, Kuhl C, Neumann UP, Meister FA, Czigany Z
Calcification of the visceral aorta and celiac trunk is associated with renal and allograft outcomes after deceased donor liver transplantation.
In: Abdominal radiology (New York)
Van den Bosch V, De Beukelaer F, Isfort P, Keil S, Kuhl CK, Bruners P, Pedersoli F
Long loop technique with bifemoral access as salvage technique for repositioning of dislodged port catheters.
In: CVIR endovascular
Barzakova E, Senthilvel N, Bruners P, Keil S, Lurje G, Zimmermann M, Kuhl CK, Isfort P
Detectability of Target Lesion During CT-Guided Tumor Ablations: Impact on Ablation Outcome.
In: RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin
Hitpass L, Distelmaier M, Neumann UP, Schöning W, Isfort P, Keil S, Kuhl CK, Bruners P, Barabasch A
Recurrent Colorectal Liver Metastases in the Liver Remnant After Major Liver Surgery-IRE as a Salvage Local Treatment When Resection and Thermal Ablation are Unsuitable.
In: Cardiovascular and interventional radiology
Pedersoli F, Van den Bosch V, Sieben P, Barzakova E, Schulze-Hagen M, Isfort P, Keil S, Wiltberger G, Kuhl CK, Bruners P
Stent Graft Placement by Pseudoaneurysm of the Hepatic Arteries: Efficacy and Patency Rate in Follow-up.
In: Cardiovascular and interventional radiology
Van den Bosch V, Pedersoli F, Keil S, Neumann UP, Kuhl CK, Bruners P, Zimmermann M
Safety and efficacy of right portal vein embolization in patients with prior left lateral liver resection.
In: Acta radiologica (Stockholm, Sweden : 1987)
Zimmermann M, Kuhl C, Engelke H, Bettermann G, Keil S
Volumetric measurements of target lesions: does it improve inter-reader variability for oncological response assessment according to RECIST 1.1 guidelines compared to standard unidimensional measurements?
In: Polish journal of radiology
Schock J, Truhn D, Nürnberger D, Conrad S, Huppertz MS, Keil S, Kuhl C, Merhof D, Nebelung S
Artificial intelligence-based automatic assessment of lower limb torsion on MRI.
In: Scientific reports
Pedersoli F, Schönau K, Schulze-Hagen M, Keil S, Isfort P, Gombert A, Alizai PH, Kuhl CK, Bruners P, Zimmermann M
Reply to: Letter to the Editor on Endovascular Revascularization with Stent Implantation in Patients with Acute Mesenteric Ischemia Due to Acute Arterial Thrombosis: Clinical Outcome and Predictive Factors.
In: Cardiovascular and interventional radiology
Van den Bosch V, Pedersoli F, Keil S, Neumann UP, Kuhl CK, Bruners P, Zimmermann M
Safety and efficacy of right portal vein embolization in patients with prior left lateral liver resection.
In: Acta radiologica (Stockholm, Sweden : 1987)
Pedersoli F, Schönau K, Schulze-Hagen M, Keil S, Isfort P, Gombert A, Alizai PH, Kuhl CK, Bruners P, Zimmermann M
Endovascular Revascularization with Stent Implantation in Patients with Acute Mesenteric Ischemia due to Acute Arterial Thrombosis: Clinical Outcome and Predictive Factors.
In: Cardiovascular and interventional radiology
Sähn MJ, Yüksel C, Keil S, Zeisberger MP, Post M, Kleines M, Brokmann JC, Hübel C, Kuhl CK, Isfort P, Schulze-Hagen MF
Accuracy of Chest CT for Differentiating COVID-19 from COVID-19 Mimics.
In: RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin
Abu Jhaisha S, Brozat JF, Hohlstein P, Wirtz TH, Hose J, Bündgens L, Keil S, Trautwein C, Koch A
Hemosuccus Pancreaticus and Obstructive Jaundice: Two Rare Complications of Chronic Pancreatitis Treated by Arterial Embolization.
In: Zeitschrift fur Gastroenterologie
Zimmermann M, Kuhl CK, Engelke H, Bettermann G, Keil S
CT-based whole-body tumor volumetry versus RECIST 1.1: Feasibility and implications for inter-reader variability.
In: European journal of radiology
Pedersoli F, Hitpass L, Isfort P, Zimmermann M, Schulze-Hagen M, Gombert A, Kuhl CK, Bruners P, Keil S
Recanalization and Stenting of the Celiac and the Superior Mesenteric Artery Supported by Use of a Steerable Introducer Sheath: Report on 2 Years' Experience.
In: Vascular and endovascular surgery
Pedersoli F, Schröder A, Zimmermann M, Schulze-Hagen M, Keil S, Ulmer TF, Neumann UP, Kuhl CK, Bruners P, Isfort P
Percutaneous transhepatic biliary drainage (PTBD) in patients with dilated vs. nondilated bile ducts: technical considerations and complications.
In: European radiology
Zimmermann M, Kuhl CK, Engelke H, Bettermann G, Keil S
Factors That Drive Heterogeneity of Response-to-Treatment of Different Metastatic Deposits Within the Same Patients as Measured by RECIST 1.1 Analyses.
In: Academic radiology
- Pedersoli F, Zimmermann M, Schulze-Hagen M, Sieben P, Barzakova E, Goerg F, Keil S, Gombert A, Kuhl CK, Isfort P, Bruners P
Retrograde Recanalization of the Celiac Artery via the Pancreaticoduodenal Arcade as a Safe and Valid Alternative to Antegrade Access.
In: Vascular and endovascular surgery. - Schulze-Hagen M, Truhn D, Duong F, Keil S, Pedersoli F, Kuhl CK, Lurje G, Neumann U, Isfort P, Bruners P, Zimmermann M
Correlation Between Sarcopenia and Growth Rate of the Future Liver Remnant After Portal Vein Embolization in Patients with Colorectal Liver Metastases.
In: Cardiovascular and interventional radiology.
- Kuhl CK, Alparslan Y, Schmoee J, Sequeira B, Keulers A, Brümmendorf TH, Keil S
Validity of RECIST Version 1.1 for Response Assessment in Metastatic Cancer: A Prospective, Multireader Study.
In: Radiology.
- Zimmermann M, Kuhl C, Keil S
Characteristic changes of the ablation zone on contrast-enhanced computed tomography after radiofrequency ablation of hepatic metastases.
In: The Indian journal of radiology & imaging.
- Distelmaier M, Barabasch A, Heil P, Kraemer NA, Isfort P, Keil S, Kuhl CK, Bruners P
Midterm Safety and Efficacy of Irreversible Electroporation of Malignant Liver Tumors Located Close to Major Portal or Hepatic Veins.
In: Radiology.
- Weber CD, Herren C, Dienstknecht T, Hildebrand F, Keil S, Pape HC, Kobbe P
Management of Life-Threatening Arterial Hemorrhage Following a Fragility Fracture of the Pelvis in the Anticoagulated Patient: Case Report and Review of the Literature.
In: Geriatric orthopaedic surgery & rehabilitation. - Behrendt FF, Lensing C, Keil S, Mottaghy FM, Verburg FA
No clinically relevant differences between positron emission tomography (PET) reconstructions based on low-dose or contrast-enhanced CT in combined integrated multiphase (18) F-Fluorethylcholine PET/CT for prostate cancer.
In: Journal of medical imaging and radiation oncology. - Pedersoli F, Isfort P, Keil S, Goerg F, Zimmermann M, Liebl M, Schulze-Hagen M, Schmeding M, Kuhl CK, Bruners P
Stentgraft Implantation for the Treatment of Postoperative Hepatic Artery Pseudoaneurysm.
In: Cardiovascular and interventional radiology.
- Park JJ, Shen A, Keil S, Kuhl C, Westhofen M
Jugular bulb abnormalities in patients with Meniere's disease using high-resolution computed tomography.
In: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery.
- Keil S, Barabasch A, Dirrichs T, Bruners P, Hansen NL, Bieling HB, Brümmendorf TH, Kuhl CK.
Target lesion selection: an important factor causing variability of response classification in the Response Evaluation Criteria for Solid Tumors 1.1.
Invest Radiol. 2014 Aug;49(8):509-17.
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