As a tertiary and quaternary level provider of medical care, the University Hospital of RWTH Aachen combines patient-oriented medicine and care, teaching and research at an international level. The entire spectrum of medical care is provided through 36 specialist departments, 33 institutes and six interdisciplinary units. The co-location of patient care, research and teaching in a central building offers the best conditions for intensive interdisciplinary exchange and close clinical and scientific networking. Highly qualified teams of doctors, nurses and scientists work collaboratively to optimise the healthcare provision of our local, regional, national and international patients. Around 9,000 employees ensure that our care delivery is patient-oriented medicine and surpasses the highest quality standards. With 1,400 beds, the university hospital treats around 50,000 inpatient and 200,000 outpatient cases per year.
The Helmholtz Institute for Biomedical Engineering -Institute of Stem Cell Biology- is offering a position for a
Bioinformatician (f/m/d) for Epigenetic Characterization of Pluripotent Stem Cells
The fulltime postdoctoral position (38,5 hours/week) starting from October 2024 and is initially limited for 2 years.
Within the project "PluripotencyScreen" ( supported by VIP+BMBF), we are developing in innovative quality control method for iPSC based on epigenetic characteristics. To this end, we need to integrate public and own DNA methylation datasets of iPSCs during differentiation towards all three embryonic germ layers- endoderm, mesoderm and ectoderm. Furthermore, we aim for a better understanding of age-ssociated epigenetic modifications. Thus, we are looking for a bioinformatican with a strong background in epigenetic characterization of cell preparations with focus on DNA methylation. We are integrating own and puplic EPIC Illumina Bead Chip datasets, RNA-seq, ATAC-seq, ChIP-seq, WGBS, and nanopore sequencing datasets.
You can find further information on our research group under: http://www.stemcellbiology.ukaachen.de
Reference: Schmidt et al., Stem Cell Reports 2023 https://doi.org/10.1016/j.stemcr.2022.11.001
Your tasks
- Identification of lineage-specific epigenetic modifications
- Derivation of DNA methylation signatures for iPSC characterization
- Analysis and integration of age-associated DNA methylation and histone modifications
- Support documentation, quality control, and project management
- Scientific publication of the results
Your profile
- Master´s degree in either Biology, Bioinformatics, or comparable degrees in Natural Science
- A successful PhD with bioinformatics on epigenetics or stem cell research
- Bioinformatic skills for DNA methylation analysis
- programming languages R and optionally perl or python
- Background knowledge in iPSC and or aging research
- Willingness to contribute to different projects within our team
- Able to communicate clearly in English and willing to work in an international team
- Interest in translational research with the perspective of spin-off
Why should you choose us?
- We provide a highly interactive and well-equipped enviroment, in an international team, with excellent partners, a broad spectrum of methods and a highly relevant research topic
- Contribution to a translational project that may result in a spin-off company
Salary group TV-L (EG 13).
This position is not gender specific.
The RWTH Aachen University Hospital promotes equal opportunities and diversity. Applications from women are expressly encouraged and if the applicant is suitable qualified, they will be given priority in accordance with the LGG. If suitably qualified, people with a registered disability will also receive priority.
Weekly hours are negotiable.
You should preferably use our digital application portal at www.karriere.ukaachen.de for your application. There you have the option of securing your documents in the electronic application folder to prevent unauthorized access. Applications that reach us by email to: bewerbung@ukaachen.de (this transmission path cannot be as effectively secured) will be transferred to the aforementioned portal and any accompanying documents will be disposed of in accordance with data protection regulations immediately after transfer. After the retention period has expired, the data in the portal will also be deleted. If you do not agree to a transfer to the Application portal your application cannot be considered.
Please include (1) a cover letter, which specifically emphasizes your interest in this project, (2) CV with publication list, (3) contacts of two references, and (4) copies of the most important certificates ( with grades).
The application deadline for the advertised position GB-P-48703 is 15th of August 2024.
Uniklinik RWTH Aachen, Helmholtz Institute for Biomedical Engineering -Institute of Stem Cell Biology-, Prof. Dr. Wolfgang Wagner, M.D.,Ph.D., Pauwelsstr.30, 52074 Aachen.
For more detailed information please contact Prof. Dr. Wolfgang Wagner, M.D., Ph.D., E-Mail: wwagnerukaachende or Katharina Hayat E-mail: khayatukaachende
