The Clinic for Gastroenterology, Metabolic Diseases and Internal Intensive Care Medicine (Medical Clinic III)-research group Professor Dr. PavelStrnad- has an opening for a
PhD student (f/m/d)
The position is currently available at 65% (25,025 hours/week) part-time and initially limited for 3 years with an option of prolongation up to the completion of the doctoral degree.
Are you passionate about unravelling the mysteries of liver diseases? Join our team, which has over 20 years of experience in research of liver diseases.
Tasks
1. Investigating the Role of Patient-Derived Immune Cells in Alpha1-Antitrypsin Deficiency (AATD)
Alpha1-antitrypsin deficiency (AATD) is a genetic disorder characterized by mutations in the alpha1-antitrypsin (AAT) gene that predominantly affects lung and liver. Individuals with severe AATD mutations, such as the PiZZ genotype, face increased risks of liver cirrhosis and lung emphysema. Over the past 10 years, our group has collated a worldwide unique and well characterised human tissue samples. In your thesis, you will take advantage of these patient-derived cells to study how neutrophils contribute to AATD. The research will explore the impact of inflammation, immune cell activation, and their interactions with liver function. Advanced omics analyses and biochemical assays will be employed.
2. Investigating the Impact of HSP90 in Liver Disease
This project will examine the role of Heat Shock Protein 90 (HSP90) in liver health and will take advantage of a newly generated liver-specific HSP90 knockout animals. HSP90 is a molecular chaperone involved in maintaining protein homeostasis and cellular stress responses, particularly in tumor development. We will use biochemical assays, histological analyses, and molecular studies in animal models to uncover how HSP90 affects liver function.
Main activity:
- Development of individual research projects
- Participation and support for existing projects
- Support for teaching and
- Writing scientific publications, conference papers
Profile
- Master's degree in Life Sciences or related field
- Scientific background in biology, molecular biology, immunology, or related disciplines
- Experience in basic and translational research
- Desirable:
- Experience with model organisms and bioinformatics tools is welcome
- Ability to independently drive research projects
- Proficiency in English (Level C1), with strong communication and leadership skills
Why should you choose us?
- Salary in accordance with provisions based on german TV-L (EG 13)
- 30 days vacation/year for full-time employees
- Employees who recruit employees for nursing care get a bonus of 3,000 euros
- An attractive VBL company pension scheme
- Further education and training opportunities
- Attractive conditions for local traffic transport system
- A company kindergarten (places subject to availability)
- Staff residence (places subject to availability and by arrangement)
- An onboarding app for new employees
- Extended opening hours for our staff restaurant
This position is not gender specific.
The RWTH Aachen University Hospital promotes equal opportunities and diversity. Applications from women are expressly encouraged and if the applicant is suitable qualified, they will be given priority in accordance with the LGG. If suitably qualified, people with a registered disability will also receive priority.
Weekly hours are negotiable.
You should preferably use our digital application portal at www.karriere.ukaachen.de for your application. There you have the option of securing your documents in the electronic application folder to prevent unauthorized access. Applications that reach us by email to: bewerbung@ukaachen.de (this transmission path cannot be as effectively secured) will be transferred to the aforementioned portal and any accompanying documents will be disposed of in accordance with data protection regulations immediately after transfer. After the retention period has expired, the data in the portal will also be deleted. If you do not agree to a transfer to the Application portal your application cannot be considered
The application deadline for the advertised positione GB-P-49399 is 22.11.2024.
Uniklinik RWTH Aachen, Clinic for Gastroenterology, Metabolic Diseases and Internal Intensive Care Medicine (Medical Clinic III) -research group Professor Dr. Pavel Strnad-, Pauwelsstraße 30, 52074 Aachen.
For more detailed information please contact Nurdan Güldiken, Tel.: +49 (0)241 80 80662, E-Mail: ngueldikenukaachende
