DEG/ENaC ion channels serve different functions: in some animals they detect mechanical stimuli, in others they detect pheromones, and in humans they are sensitive for acid and are important for reabsorption of Na+. However, many DEG/ENaCs interact with neuropeptides. In a recent review, which appeared in The Journal of Physiology, we summarize what is known about this interaction and address the questions, whether there is a common structural basis for this interaction and whether it has an ancient origin. We come to some surprising answers.
