What ist he role of acid-sensing ion channels in tumour cells??

Acid-sensing ion channels (ASICs) are proton-gated Na⁺-channels, which are normally expressed in neurons. However, also many tumour cells express ASICs. Because tumour cells thrive in an acidic microenvironment, ASICs could work as proton-sensors in tumour cells. In our review article, which has been published in Pflügers Archiv – European Journal of Physiology, summarizes the current state of knowledge on the role of ASICs in tumour cells.