Message archive
A novel mechanism of ADP-ribose-directed activation of a species variant of the human apoptosis-related TRPM2 channel
ADP-ribose is the central metabolite emerging from degradation of the redox carrier NAD and is closely correlated with cellular apoptosis mediated by oxidative stress. This includes the so-called…
Our former scientist Pia Bresenitz successfully finished her PhD thesis
Today our PhD student Pia Bresenitz successfully defended her dissertation entitled "Einfluss pathophysiologischer Konzentrationen von Ammonium auf die Transkription und Funktion von Acid-Sensing Ion…
Functional characterisation of two important heteromeric Acid-Sensing Ion Channels of the CNS
Acid-sensing ion channels (ASICs) are proton-gated ion channels that are involved in the synaptic transmission at synapses of the brain and which influence the pathophysiological outcome of, for…
Intrazelluläre Lokalisation eines Acid-Sensing Ion Channels nach heterloger Expression
Acid-sensing ion channels (ASICs) sind Protonen-aktivierte Ionenkanäle mit wichtigen physiologischen Funktionen und Einfluss auf die Pathophysiologie einiger Krankheiten. ASIC4 ist der ASIC-Subtyp,…
Stem cell derived human nociceptors contain specific sets of voltage-gated sodium channels
The study of human peripheral pain is severely hampered by the lack of adequate human model systems. Recently, a protocol was published with which it is possible to produce peripheral sensory neurons…
Dr. Dominik Wiemuth was awarded the Venia legendi
Today our colleague Dr. Dominik Wiemuth was awarded the Venia legendi for Physiology by the Medical Faculty of the RWTH Aachen, based on his habilitiation „The Brain-Liver-Intestine Na+ Channel…
Our former scientist Cathérine Lefèvre successfully finished her PhD thesis
Today our PhD student Cathérine Lefèvre successfully defended her dissertation entitled " Pharmakologische und elektrophysiologische Charakterisierung des humanen intestinalen Natriumkanals (hINAc)".…
Our scientist Katrin Augustinowski successfully finished her PhD thesis
Today our PhD student Katrin Augustinowski successfully defended her dissertation entitled "Energetical contributions of intersubunit salt bridges of rASIC1a and investigations about the stoichiometry…
Characterization of an orthologue of the mammalian apoptosis channel TRPM2 from the cnidarian Nematostella vectensis
Ion channels of the der Transient Receptor Potential (TRP)-family are universal cellular sensors and effectors. Currently we examine TRPM2 which has been shown to be involved in cellular apoptosis…
Voltage-sensor trapping as a mechanism of painful gain-of-function mutations
Mutations in the voltage-gated sodium channel Nav1.7 are known to be linked to the inherited pain syndrome Erythromelalgia. The majority of these mutations produce a prominent shift of their…
New insights from genetic pain syndromes
Erythromelalgia is, like PEPD (paroxysmal extreme pain disorder), a rare inherited severe pain syndrome caused by mutations in the voltage-gated sodium channel Nav1.7. Clinically both diseases are…
Our scientist Mathis Winking successfully finished his PhD thesis
Today our PhD student Mathis Winking successfully defended his dissertation entitled "Functional cooperation of the transmembrane segments S3 and S4 during the gating process of TRPM8." We sincerely…
